peer reviewed medical research program discovery award

Congressionally Directed Medical Research Programs (CDMRP) -- Peer Reviewed Medical Research Program (PRMRP) -- Discovery Award

The PRMRP Discovery Award is intended to support innovative, untested, non-incremental, high-risk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications. The proposed project may be exploratory, hypothesis-driven, or hypothesis-generating research but must be novel and must be based on a strong scientific rationale and a well-developed study design and plan of analysis. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation or product development. The outcome of research supported by this award should be the generation of robust preliminary data that can be used as a foundation for groundbreaking future research projects.

This award is not intended to support/validate ongoing research and inclusion of preliminary data is not allowed. Inclusion of preliminary data other than serendipitous finding is not consistent with the exploratory nature of this award. Applicants seeking funding for research to further an existing research project should consider one of the other FY24 PRMRP program announcements being offered. For information about these award mechanisms, see Section II.A.1, FY24 PRMRP Research Development Pipeline..

Deadlines: • Required Pre-Application Deadline: May 6, 2024 • Application Submission Deadline: May 23, 2024

AUTOIMMUNE DISORDERS AND IMMUNOLOGY
CARDIOVASCULAR HEALTH
INFECTIOUS DISEASES
INTERNAL MEDICINE
NEUROSCIENCE
ORTHOPAEDIC MEDICINE
RARE DISEASES AND CONDITIONS
RESPIRATORY HEALTH

Investigators at the level of postdoctoral fellow or clinical fellow (or equivalent) and above may be named by the organization as the Principal Investigator (PI) on the application.

Each investigator may be named on only one FY24 PRMRP DA application as a PI.

The anticipated direct costs budgeted for the entire period of performance for an FY24 PRMRP Discovery Award should not exceed $275,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

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Peer Reviewed Medical Research Program (PRMRP)

The Peer Reviewed Medical Research Program (PRMRP), established in fiscal year 1999 (FY99), has supported research across the full range of science and medicine, with an underlying goal of enhancing the health, care, and well-being of military Service Members, Veterans, retirees, and their family members.

FY2023 Funding Mechanisms have been announced! The Congressionally Directed Topic Areas include:

Clinical Trial Award (CTA)
Discovery Award (DA)
Focused Program Award (FPA)
Investigator-Initiated Research Award (IIRA)
Lifestyle and Behavioral Health Interventions Research Award (LBIRA)
Technology/Therapeutic Development Award (TTDA)

Letter of Intent is Due: April 19th, 2023

Full Applications are Due: May 31st, 2023

Learn more about this opportunity at https://cdmrp.health.mil/funding/prmrp

Notice of Special Interest (NOSI): Halting Tuberculosis (TB) Transmission
Analyzing Early Events in TB and TB/HIV Infection for Interventional Targets (R01 - Clinical Trial Not Allowed) expires 10/12/2023

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ABOUT THE IPC
DoD Peer Reviewed Medical Research Program Announcement

| (Administrator)

Reviewers will be blinded to the identity of the Principal Investigator (PI), collaborators, and their organization(s).

for direct costs (plus indirect costs)

years

Focused Program Award – Preproposal due April 23, 2020

Full Professor level or above (or equivalent)

Research team of highly qualified, multidisciplinary project leaders should be led by a PI with demonstrated success in directing large, focused projects.

for direct costs (plus indirect costs)

Investigator-Initiated Research Award – Preproposal due April 23, 2020

Assistant Professor level or above (or equivalent)

Clinical trials will not be funded.

for direct costs (plus indirect costs)

for direct costs (plus indirect costs) for applications including a Partnering PI Option

· Maximum period of performance is 4 years

Technology/ Therapeutic Development Award – Preproposal due April 23, 2020

for direct costs (plus indirect costs

years

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org . For more information about the PRMRP or other CDMRP-administered programs, please visit the CDMRP website ( https://cdmrp.army.mil ).

Point of Contact:

FEIN: 52-1784596

DoD Peer Reviewed Medical Research Program

Discovery award.

Amount of funding: Direct Costs budgeted for the entire period of performance will not exceed $200,000. Purpose: The intent of the PRMRP DA is to support innovative, non-incremental, high-risk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a sound scientific rationale and study design. This award mechanism may not be used to conduct clinical trials; however, non-interventional clinical research studies are allowed . PI Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be the PI or Partnering PI. Stanford eligibility clarification - Fellows are not eligible : even though the guidelines indicate "postdoctoral fellow or clinical fellow" may serve as PI, the application and guidelines do not require to a mentor. Therefore, this award is considered a research grant in which the Stanford PIship policy only permits faculty to apply. Since it is not mentored career development award, Instructors, Clinical Instructors, Academic Staff-Research (i.e., research associates), Postdocs, and Clinical fellows are not eligible (they may not submit career development PI waivers). Timeline: Pre-Application (Letter of Intent) Submission Deadline: March 29, 2023 via eBrap Please include your RPM’s name as business official in the pre-application. Institutional representative (RPM/RMG or CGO/OSR) Deadline: April 19, 2023 Application submission Deadline: April 26, 2023 via grants.gov Guidelines: https://cdmrp.army.mil/funding/prmrp

Focused Program Award

Amount of funding: Direct Costs budgeted for the entire period of performance will not exceed $7.2M. Purpose: The FY23 PRMRP Focused Program Award (FPA) is intended to optimize research and accelerate solutions to a critical question related to one of the congressionally directed FY23 PRMRP Topic Areas and one of the FY23 PRMRP Strategic Goals through a synergistic, multidisciplinary research program. Lead PI Eligibility : Stanford Full Professor with PI eligibility. The PI is required to devote a minimum of 20% effort to this award. Project Leader Eligibility : must be at or above the level of Assistant Professor with PI eligibility or a CE Assistant Professor (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) Not eligible : Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and postdocs are not eligible for this RFP because Stanford does not consider them to be independent positions. Timeline: REQUIRED Pre-Application (Pre-Proposal) Deadline: April 12, 2023 via eBrap Please include your RPM’s name as business official in the pre-application. Institutional representative (RPM/RMG or CGO/OSR) Deadline: July 12, 2023 Application Submission Deadline: July 19, 2023 via grants.gov Guidelines: https://cdmrp.army.mil/funding/prmrp

Investigator-Initiated Research Award

Amount of funding: Direct Costs budgeted for the entire period of performance will not exceed $1.6M. Direct Costs budgeted for the entire period of performance with the Partnering PI Option will not exceed $2M. Purpose: The PRMRP Investigator-Initiated Research Award (IIRA) is intended to support studies that will make an important contribution toward research and/or patient care for a disease or condition related to one of the FY23 PRMRP Topic Areas and one of the FY23 PRMRP Strategic Goals. PI Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be the PI or Partnering PI. Not eligible : Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and postdocs are not eligible for this RFP because Stanford does not consider them to hold independent positions. Timeline: Pre-Application (Letter of Intent) Submission Deadline: April 19, 2023 via eBrap Please include your RPM’s name as business official in the pre-application. Institutional representative (RPM/RMG or CGO/OSR) Deadline: May 23, 2023 Application submission Deadline: May 31, 2023 via grants.gov Guidelines: https://cdmrp.army.mil/funding/prmrp

Technology/Therapeutic Development Award

Amount of funding: Funding Level 1 Direct Costs will not exceed $2M. Funding Level 2 Direct Costs will not exceed $4M. Purpose: The PRMRP Technology/Therapeutic Development Award (TTDA) is a product-driven award mechanism intended to provide support for the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, treatment, or quality of life, for a disease or condition related to one of the FY23 PRMRP Topic Areas and one DOD FY23 Peer Reviewed Medical Technology/Therapeutic Development Award 11 of the FY23 PRMRP Strategic Goals. Products in development should be responsive to the health care needs of military Service Members, Veterans, and/or beneficiaries. This award mechanism may not be used to conduct clinical trials. Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be the PI. Not eligible : Instructors, Clinical Instructors, Postdoctoral Fellows, Clinical Fellows, Academic staff-researchers (i.e., research associates) are not eligible because Stanford does not consider them to hold independent or faculty-level positions. Timeline: Pre-Application (Letter of Intent) Submission Deadline: April 19, 2023 via eBrap Please include your RPM’s name as business official in the pre-application. Institutional representative (RPM/RMG or CGO/OSR) Deadline: May 23, 2023 Application submission Deadline: May 31, 2023 via grants.gov Guidelines: https://cdmrp.army.mil/funding/prmrp

Clinical Trial Award

Amount of funding: Direct Costs budgeted for the entire period of performance will not exceed $500,000. Purpose: The FY23 PRMRP Clinical Trial Award (CTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on a disease or condition addressed in one of the congressionally directed FY23 PRMRP Topic Areas and FY23 PRMRP Strategic Goals. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs DOD FY23 Peer Reviewed Medical Clinical Trial Award 11 or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first in human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials through large-scale trials to determine efficacy in relevant patient populations . PI Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be the PI or Partnering PI. Not eligible : Instructors, Clinical Instructors, Academic staff-research (i.e., research associates), and Postdocs are not eligible for this RFP because Stanford does not consider them to hold independent positions. Timeline: REQUIRED Pre-Application (Pre-Proposal) Deadline: April 12, 2023 via eBrap Please include your RPM’s name as business official in the pre-application. Institutional representative (RPM/RMG or CGO/OSR) Deadline: July 12, 2023 Application Submission Deadline: July 19, 2023 via grants.gov Guidelines: https://cdmrp.army.mil/funding/prmrp

Lifestyle and Behavioral Health Interventions Research Award

Amount of funding: Direct Costs for the entire period of performance will not exceed $3M. Purpose: The FY23 PRMRP Lifestyle and Behavioral Health Interventions Research Award (LBIRA) supports clinical research and/or clinical trials using a combination of scientific disciplines including behavioral health, psychology, psychometrics, biostatistics and epidemiology, surveillance, and public health. Applications are required to address and provide a solution to DOD FY23 Peer Reviewed Medical Lifestyle and Behavioral Health Interventions Research Award 11 one of the congressionally directed FY23 PRMRP Topic Areas and FY23 PRMRP Strategic Goals. Eligibility: Independent investigators - Faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver obtained through their RPM in RMG prior to the pre-application/letter of intent) may be the PI. Not eligible : Instructors, Clinical Instructors, Postdoctoral Fellows, Clinical Fellows, Academic staff-researchers (i.e., research associates) are not eligible because Stanford does not consider them to hold independent or faculty-level positions. Timeline: Pre-Application (Letter of Intent) Submission Deadline: April 19, 2023 via eBrap Please include your RPM’s name as business official in the pre-application. Institutional representative (RPM/RMG or CGO/OSR) Deadline: May 23, 2023 Application submission Deadline: May 31, 2023 via grants.gov Guidelines: https://cdmrp.army.mil/funding/prmrp

Additional Information

Please include your institutional official's name (RPM/RMG or CGO/OSR) as business official in the pre-application/LOI.

eBRAP Funding Opportunities and Forms (including the General Application Instructions).

Please go to eBRAP.org and log into your account
Click on "My Organizations" in the dropdown menu located to the left of the Log Out button
Click on Organization Profile Tab which will display current details for the organization you have approved.
Scroll to the bottom of the page and click the "Edit Organization" button
Make any necessary changes to the profile including entering the UEI
Please contact [email protected] for assistance or if you wish to deactivate your account if no longer needed

Funding Opportunities and Forms

Peer reviewed medical research program(prmrp).

Show All Current Funding Opportunities

NOTE: Award mechanism-specific forms shown above supercede the generic documents below. If the form is not listed with the award mechanism, please use the generic version of the form

CDMRP Webinar Series

Generic Forms for Application Submission

	MS Office	PDF
Suggested CDMRP Biographical Sketch		n/a
Suggested Quad Chart Template (Legacy)		n/a
Suggested Quad Chart Template (NEW, PPTX version)		n/a
Suggested Intragovernmental/Intramural Budget (NEW)	n/a
Common Blinding Mistakes and How to Avoid Them	n/a
Suggested SOW Format
Example: Assembling a Clinical Research and/or Clinical Trial Statement of Work
Example: Assembling a Generic Statement of Work
Public Health Service Inclusion Enrollment Report	n/a

Regulatory Document Forms

MS Office	PDF
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Environmental Compliance Assurance
eBRAP Regulatory File Drop-Off Instruction Guide	n/a
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Progress Report Formats

MS Office	PDF
Award Expiration Transition Plan	n/a
Annual/Final Technical Progress Report Template		n/a
Semi-Annual Technical Progress Report Template		n/a
Quarterly Technical Progress Report Template		n/a
Quad Chart Template		n/a
Award Chart Template		n/a
Public Health Service Inclusion Enrollment Report	n/a
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Organizational Forms

	Word	PDF
Required Representations	n/a
DD882- Report of Inventions and Subcontract (New)	n/a
SF425 - Federal Financial Report	n/a

Resources and Reference Material

	Word	PDF
	Research Classification Codes	n/a
	Planning and Executing a Successful Research Consortium or Complex Collaboration	n/a
	Guide for Funded Investigators	n/a
	eBRAP Regulatory File Drop-Off Instruction Guide	n/a
	Guide for Intragovernmental & Intramural Applicants	n/a
	Policy on Data & Resource Sharing	n/a
	Position on Research Duplication	n/a
	VA/DoD Collaboration Guidebook for Healthcare Research 2013	n/a
	eBRAP Technical Report Submission Guide	n/a
	Policy on Inclusion of Women and Minorities	n/a
	Frequently Asked Questions for Policy on Inclusion of Women and Minorities	n/a
	Public Health Service Inclusion Enrollment Report	n/a
	Policy on Sex as a Biological Variable in Research	n/a
	Frequently Asked Questions for Policy on Sex as a Biological Variable	n/a

You may get a free copy of the Adobe® Reader® to view the PDF files on this page.

To save a copy of the forms above, right-click on the name and select from the pop-up menu that is displayed either "Save Target As...", or "Save Link As..." or something similar in your browser.

PRIVACY ACT STATEMENT

Authorities : Section 113, Title 10, United States Code: Secretary of Defense Federal Acquisition Regulations Part 4.5.

Purposes : The information will be used in connection with the selection of qualified proposals submitted by applicants in order to make research awards. To permit authorized individuals to view their data for purpose of verifying its accuracy and to update the data when it is not current or is inaccurate. To audit user access to ensure that access is only granted to users that are authorized access to the information

Routine Uses : The information requested may be disclosed to qualified reviewers and staff assistants as part of the proposal review process, funding decisions, or the administration of research awards; or to other government agencies for comparison of funded research. eBRAP does not share information with any private organizations and does not collect information for commercial marketing.

Disclosure : Submission of the information is voluntary. Failure to provide full and complete information, however, may reduce the possibility of receiving a research award.

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Mentored Clinical Investigator Career Development award, CUMC’s NIH CTSA KL2 program “Physician and Patient Attitudes and Preference Regarding Disease Monitoring in Metastatic Hormone Receptor Positive Breast Cancer in SWOG 1703: Cross-Sectional Companion Study”


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3-year Florence and Herbert Irving Clinical Research Career Award (“Irving Scholars”), Irving Institute for Clinical and Translational Research “Precision Targeting of HAT Enzymes to Activate Immune Surveillance”


Parker B. Francis Fellowship, Francis Family Foundation “Visceral Adipose Tissue and Frailty in Idiopathic Pulmonary Fibrosis”
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5-year new R01, NIH/NCI “Novel Predictors of Survival Among Breast Cancer Patients With/Without HIV in South Africa”

(mentor: Dr. Michael Shen)
Tomasello Family Women Who Conquer Cancer Young Investigator Award, Conquer Cancer Foundation/American Society of Clinical Oncology “A Reverse-Engineering Approach to Investigate Drivers of Therapy Resistance in a Co-Clinical Study of Bladder Cancer using Patient-Derived Organoids”


[Multiple PI award with Dr. Stavroula Kousteni (Dept. of Physiology and Cellular Biophysics)] Pilot Award to Advance Precision Medicine Research, Irving Institute for Clinical and Translational Research “A microRNA Approach to Identify Renal Osteodystrophy Sub-Type”


2-year new Exploratory/Developmental Research Grant (R21), NIH/NIAID “Targeted Next-Generation Sequenci ng to Enhance Detection and Genomic Characterization of Mycobacterium Tuberculosis and High-Impact Bacterial Pathogens among HIV-Infected Adults with Sepsis in Uganda”
Research Data Sharing Award, Doris Duke Charitable Foundation

[Multi PI grant with Dr. Tiffany Sanchez (Dept. of Environmental Health Sciences)]
2-year new Exploratory/Developmental Research Grant (R21), NIH/NHLBI “Respiratory Health and Cigar and Pipe Use in the NHLBI Pooled Cohorts Study”


2-year new Translational Research Grant, Pancreatic Cancer Action Network “Therapeutic Induction of Tumor Selective Ferroptosis in Pancreatic Cancer”

(mentor: Dr. Muredach Reilly)
2-year Postdoctoral Fellowship, American Heart Association “Functional Investigation of lincADAIN in Obesity-Induced Adipose Tissue Inflammation”


3-year new R01, NIH/NIDDK “Hepatic Rap1 in Glucose Homeostasis”

[Multiple PI award with Dr. Kelley Gabriel (Univ of Alabama at Birmingham)]
4-year new R01, NIH/NIA “24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer’s Disease in African Americans: The Jackson Heart Study”


4-year competing renewal, NIH/NIDDK “Notch, Type 2 Diabetes and NAFLD”

(mentor: Hans W. Snoeck)
3-year Irvington Postdoctoral Fellowship Award, Cancer Research Institute “Role of Mitofusin 2 in Hematopoietic Stem Cell Function and Age-Related Malignancies”


[Multiple PI award with Dr. Mingyao Li (University of Pennsylvania)] 4-year new R01, NIH/NHLBI “Computational and Functional Strategies to Decipher lncRNAs in Human Atherosclerosis”

(mentor: Mathew Maurer)
Glorney-Raisbeck Fellowship, New York Academy of Medicine “Delineating Mechanisms Underlying the Efficacy of Emerging Therapies for Transthyretin Cardiac Amyloidosis with Noninvasive Pressure-Volume Relationships”


4-year Regenerative Medicine Focused Research Award (RMFRA), DOD/CDMRP/Defense Medical Research and Development Program/Clinical and Rehabilitative Medicine Research Program “Immunologic Basis for Tolerance of Genetically Disparate Muscle in Chimeric Animals”

[Multiple PI award with Drs. Martin Pollak (Beth Israel Deaconess Medical Center), Friedhelm Hildebrandt (Boston’s Children’s Hospital) and Matthew Sampson (University of Michigan)]
5-year High impact, Interdisciplinary Science grant, NIH/NIDDK “Integrating Large Scale Genomics and Functional Studies to Accelerate FSGS/NS Discovery”


1-year Research Training Award for Fellows (RTAF), American Society for Hematology “Examining Mesenchymal Stromal Cells as a Therapeutic Vulnerability in Primary Myelofibrosis”


COVID-19 Rapid Response Award, American Heart Association “A Comprehensive Assessment of Arterial and Venous Thrombotic Complications in Patients with COVID-19”

(mentor: Dr. Sanja Jelic)
Focused Projects Award for Junior Investigators, American Academy of Sleep Medicine Foundation "Insufficient Sleep in Women and Endothelial Cell Oxidative Stress"

([Multiple PI award with Dr. Bernard Chang (Dept. of Emergency Medicine)]
5-year new R01, NIH/NHLBI “The Identification of Modifiable Emergency Department and Sleep Factors Contributing to Psychological and Cardiovascular Risk in Clinicians”


5-year new R01, NIH/NCI “Investigating Lineage Plasticity in Castration-Resistant Prostate Cancer”


2-year Research Scholars Program in Liver Disease, Gilead Sciences “A Novel Subcellular Mediator of Steatosis and NASH”

(Multiple PI award with Dr. Wafaa El-Sadr)
Administrative supplemental funds for the emergency response to COVID-19, NIH/NIAID


4-year R01, NIH/NIGMS “Analog-based Approaches to Isolation of Aptamers for Challenging Targets”

[with Dr. Carmela Alcantara (School of Social Work)]
Addressing Racism: Faculty Seed Grant Opportunity - Cross-Unit Collaboration, Columbia University/Office of the Provost “Sleep Center of Excellence Seminar Special Series on Discrimination, Social Injustice, and Sleep"


5-year Institutional Research Training Grant, NIH/NIAID "Training in Translational Immunology Research"
[Multiple PI award with Dr. Kazuhiko Yamada (Dept. of Surgery)] Emergency Competitive Revision, NIH/NIAID “Human Immune System Mouse Models for Studies of COVID-19”
3-year Contract, NIH/NIAID “Characterizing and Improving Humanized Immune System Mouse Models (IMM-HIS)”

(mentor: Dr. Megan Sykes)
2-year Resident Research Fellowship, American College of Surgeons “The Impact of Hybrid Thymic and Mixed Xenogeneic Chimerism on Tolerance, Homeostasis and Function of T Cells in a Humanized Mouse Model”


Transatlantic Networks of Excellence in Cardiovascular, Leducq Foundation for Cardiovascular Research “Clonal Hematopoiesis and Atherosclerosis and COVID19”

(mentor: Dr. Remi Creusot)
3-year Postdoctoral Fellowship, JDRF “Thymic Selection of Human Diabetogenic T cells”


1-year COVID-19 Rapid Response Award, American Heart Association “Elucidating the Pathogenesis of COVID-19 Cardiac Disease through snRNA-Seq and Histopathological Analysis of Human Myocardium”


2-year new Exploratory/Developmental Research Grant (R21), NIH/NIAID “Group 1 CD1-Restricted Human T Cells Induced by a Whole Sporozoite-Based Malaria Vaccine


Addressing Racism: Faculty Seed Grant Opportunity - Individual Unit Project, Columbia University/Office of the Provost “Seminars in African American History of Medicine”


5-year new R01, NIH/NCI “The Role of the Microbiome in HPV-Associated Cervical Cancer in Women with HIV”
[Multi PI award with Drs. Tal Korem (Dept. of Systems Biology), George Gallos (Dept. of Anesthesiology) and Joy-Sarah Vink (Dept. of Obstetrics and Gynecology)] Roy and Diana Vagelos Precision Medicine Pilot Award “Mechanistic Investigation of the Vaginal Microbiome in Different Manifestations of Spontaneous Preterm Birth”


Addressing Racism: Faculty Seed Grant Opportunity - Individual Unit Project, Columbia University/Office of the Provost “Black Liver Health Initiative - Outreach Campaign"
Multiple PI award with Dr. Jasmohan Bajaj (Virginia Commonwealth University)] 2-year new Exploratory/Developmental Research Grant (R21), NIH/NCATS “Gut Microbiota in the Modulation of Outcomes after Liver Transplant”


1-year Research Grant, Saving Tiny Hearts Society “Understanding Cardiac Arrhythmias in Congenital Heart Disease using a Novel 3D Panoramic Optical Mapping System”
5-year new R01, NIH/NHLBI “Understanding the Role of Mitochondrial Dysfunction in Cardiac Arrhythmias using a Novel 3D Panoramic Optical Mapping System”


1-year Alzheimer’s-Focused Administrative Supplement, NIH/NHLBI “JAK2V617F, Clonal Hematopoiesis and Atherosclerosis”


5-year Mentored Patient-Oriented Research Career Development Award (K23), NIH/NIAMS “Comparative Effectiveness Research in Axial Spondyloarthritis”


5-year new R01, NIH/NIDDK “Changes in CSF Biomarkers after Bariatric Surgery

[mentors: Drs. Simone Sanna-Cherchi and Cathy Mendelsohn (Urology)]
1-year Medical Student Research Training Supplement, NIH/NIDDK


5-year competitive R01 renewal, NIH/NIAMS “Pathogenesis of Emery-Dreifuss Muscular Dystrophy”
[Multi PI award with Dr. Reuven Stein (Tel Aviv University)] 4-year Research Grant, U.S. - Israel Binational Science Foundation “Non-Canonical Action of Bax at the Nuclear Envelope”


Pew-Stewart Scholars for Cancer Research, Pew Charitable Trusts and the Alexander and Margaret Stewart Trust “Dysregulation of Messenger RNA Structure in the Development of Breast Cancer”
5-year Director's New Innovator Award (DP2), NIH/Office of the NIH Director “Genome-Wide Studies of the Noncoding Functions and Mechanisms of Human mRNAs”


Career Scientist Award, Irma T. Hirschl Trust “Targeting the Stem Cell Niche for Prevention and Treatment of Colorectal Tumorigenesis”
5-year Director's New Innovator Award (DP2), NIH/Office of the NIH Director “Directing Cell Fate Along the Intestinal Enteroendocrine Lineage”
5-year new R01, NIH/NIA “Intestinal Stem Cell Function During Aging and Tumor Initiation”


5-year new R01, NIH/NHLBI “Discovering Wdfy3 as a Novel Regulator of Macrophage Efferocytosis by Genomewide CRISPR Screen”


2-year Emergency Competitive Revision, NIH/NIAID “Development and Significance of the Plasma Cell Niche in the Human Infant Thymus”


5-year Mentored Patient-Oriented Research Career Development Award (K23), NIH/NIAID “Harnessing Bioinformatics for HIV Prevention: Understanding Persistence in Comprehensive HIV Prevention Services”

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ABOUT THE IPC
DoD Peer Reviewed Medical Research Program Funding Opportunity

| (Administrator)

FY21 PRMRP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website.

: Applications submitted to the FY21 PRMRP must address at least one of the FY21 PRMRP Congressionally directed topic areas. As of the release date of this pre-announcement, the FY21 PRMRP Topic Areas have not been finalized. This pre-announcement should not be construed as an obligation by the Government to include any of these Topic Areas or others in the FY21 PRMRP. The potential FY21 PRMRP Topic Areas are as follows:

Arthritis Burn pit exposure Cardiomyopathy Congenital heart disease Diabetes Dystonia Eating disorders Emerging viral diseases Endometriosis Epidermolysis bullosa Familial hypercholesterolemia Fibrous dysplasia Focal segmental glomerulosclerosis Food allergies Fragile X Frontotemporal degeneration Hemorrhage control Hepatitis B Hydrocephalus Hypertension Inflammatory bowel diseases Malaria Metals toxicology Mitochondrial disease Myalgic encephalomyelitis/chronic fatigue syndrome Myotonic dystrophy Non-opioid therapy for pain management Nutrition optimization Pathogen-inactivated blood products Peripheral neuropathy Plant-based vaccines Platelet like cell production Polycystic kidney disease Pressure ulcers Pulmonary fibrosis Respiratory health Rheumatoid arthritis Sleep disorders and restriction Suicide prevention Sustained release drug delivery Vascular malformations Women's heart disease

Assistant Professor level or above (or equivalent)

Preproposal submission is required; application submission is by invitation only. Supports the rapid implementation of clinical trials of novel interventions with the potential to have a significant impact on patient care in the topic area(s) of interest. Proposed projects may range from small proof-of-concept trials through large-scale, definitive trials. Two options will be offered: : Provides support to prepare and submit an Investigational New Drug/Investigational Device Exemption (IND/IDE) application to the U.S. Food and Drug Administration (FDA) and requires FDA/regulatory approval or exemption to proceed before the Clinical Trial Award is made. : Provides support for the clinical trial. Investigational New Drug or Investigational Device Exemption applications to the Food and Drug Administration (FDA), if needed, must be approved by the FDA included in the application submission. : Funding limit not defined; requested funding must be appropriate for the scope of work proposed Maximum period of performance is years for the clinical trial : Maximum of for direct costs (plus indirect costs) for the Planning Phase Option Maximum period of performance is for the Planning Phase Option

Postdoctoral fellow or clinical fellow (or equivalent) and above

Supports the exploration of a highly innovative new concept or untested theory. Not intended to support the logical progression of an already established line of questioning. Reviewers will be blinded to the identity of the Principal Investigator (PI), collaborators, and their organization(s). Clinical trials will not be funded. Maximum of for direct costs (plus indirect costs) Maximum period of performance is years

Full Professor level or above (or equivalent)

Preproposal submission is required; application submission is by invitation only. Supports a synergistic, multidisciplinary research program of at least four distinct but complementary projects addressing an overarching goal. Projects should work together to answer critical questions, resolve differing hypotheses, and translate laboratory findings to clinical applications. Projects may range from exploratory/hypothesis-developing through small-scale clinical trials that together will address the overarching goal/question. Research team of highly qualified, multidisciplinary project leaders should be led by a PI with demonstrated success in directing large, focused projects.

Maximum of for direct costs (plus indirect costs) Maximum period of performance is years

Assistant Professor level or above (or equivalent)

Preproposal submission is required; application submission is by invitation only. Supports research that will make an original and important contribution to the field of research or patient care in the topic area(s) of interest. Partnering PI Option available. Clinical trials will not be funded. Maximum of for direct costs (plus indirect costs) Maximum of for direct costs (plus indirect costs) for applications including a Partnering PI Option Maximum period of performance is years

Assistant Professor level or above (or equivalent)

Preproposal submission is required; application submission is by invitation only. Supports the translation of promising preclinical findings into clinical applications for prevention, detection, diagnosis, treatment, or quality of life. Product-oriented (e.g., device, drug, clinical guidelines). The product(s) to be developed may be a tangible item such as a pharmacologic agent (drugs or biologics) or device, or a knowledge-based product. Two funding levels available, depending on the maturity of the product. The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under each funding level: : Supports research that is supported by significant preliminary data but has not advanced to the level of clinical translation. : Supports research that is in the final states of preclinical development with potential for near-term clinical development. Applications must provide relevant data that support the rationale for the proposed study. Funding Level 2 recipients must submit or obtain an IND/IDE application to the FDA, or must transition the product to clinical practice, within the period of performance. Clinical trials will not be funded. : Maximum of for direct costs (plus indirect costs) Maximum period of performance is years : Maximum of for direct costs (plus indirect costs) Maximum period of performance is years

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at For more information about the PRMRP or other CDMRP-administered programs, please visit the ( ).

FEIN: 52-1784596

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Ambika Bajpayee receives Department of Defense Discovery Award

Bioengineering Assistant Professor Ambika Bajpayee, who recently joined Northeastern, has been awarded a $310K DOD Peer Reviewed Medical Research Program Discovery Award. Collaborators on the grant include Sunny Zhou (Professor of Chemistry) and Sandra Shefelbine (Associate Professor of Bioengineering). This grant will fund a project on the design of cartilage targeting therapies for the treatment of osteoarthritis (OA), a degenerative joint disease which affects 150 million people around the world but does not have a cure yet. The work promises to enable clinical translation of potential disease modifying OA drugs which are currently limited by a lack of tissue targeting drug delivery systems.

Prof. Bajpayee’s lab, located in the Interdisciplinary Science and Engineering Complex (ISEC), uses concepts of nanomedicine and bio-electrostatics to design peptide and protein based carriers for targeted, sustained drug delivery to specific intra-tissue and intra-cellular sites. Her interests include understanding mechanisms leading to degenerative joint diseases due to aging and traumatic injuries.

Related Faculty: Ambika Bajpayee , Sandra Shefelbine

Related Departments:Bioengineering, Mechanical & Industrial Engineering

DOD – Peer Reviewed Medical Research Program (PRMRP)

Well-being, health and biomedical discovery.

Academic Unit: Inquire with your unit

Memorial Deadline: Thursday 30th, July 2020

External Deadline: Thursday 6th, August 2020

Description

Focused program award, investigator-initiated research award, technology/therapeutic development award.

Pre-Application (Preproposal): April 23, 2020 Invitation to Submit and Application: June 2020
Application: August 6, 2020
Detailed descriptions of the funding opportunity, evaluation criteria, and submission requirements can be found in the Program Announcements. The Program Announcements are available electronically for downloading from the Grants.gov website ( http://www.grants.gov ), the CDMRP website ( http://cdmrp.army.mil/funding/prgdefault.shtml ) and the electronic Biomedical Research Application Portal (eBRAP) ( https://eBRAP.org ).

Submission is a two-step process requiring both pre-application submission and full application submission. All pre-applications must be submitted through eBRAP ( https://eBRAP.org/ ). Full applications from extramural organizations (non-DoD organizations) must be submitted through Grants.gov ( http://www.grants.gov/ ). Intramural DoD organizations may submit full applications to either eBRAP or Grants.gov. Refer to the General Application Instructions, Section II.A. for registration and submission requirements for eBRAP and Grants.gov. For detailed information on the submission process, refer to Section II.D. of the Program Announcement/Funding Opportunity.

eBRAP is a multifunctional web-based system that allows PIs to submit their pre-applications electronically through a secure connection, to view and edit the content of their pre-applications and full applications, to receive communications from the CDMRP, and to submit documentation during award negotiations and period of performance. A key feature of eBRAP is the ability of an organization’s representatives and PIs to view and modify the Grants.gov application submissions associated with them. eBRAP will validate Grants.gov application files against the specific Program Announcement/Funding Opportunity requirements and discrepancies will be noted in an email to the PI and in the Full Application Files tab in eBRAP. It is the applicant’s responsibility to review all application components for accuracy as well as ensure proper ordering as specified in this Program Announcement/Funding Opportunity.

Funding Sources

Department of defence - united states of america.

Funding Opportunity | Congressionally Directed Medical Research Programs FY23 Applications Open

University of utah health.

Patient Care
U Health Plans

The Department of Defense has opened in FY23 application period for the Peer Reviewed Medical Research Program (PRMRP).

PRMRP, established in fiscal year 1999 (FY99), has supported research across the full range of science and medicine, with an underlying goal of enhancing the health, care, and well-being of military Service Members, Veterans, retirees, and their family members. Program oversight is provided by a programmatic panel with joint military service and interagency representation. Congressional appropriations for the PRMRP totaled $2.35 billion through FY19 and have supported over 1600 awards in over 155 different topic areas. Congress appropriated $360 million for the FY20 program to solicit proposals in 44 topic areas.

There are a variety of funding opportunities in multiple areas, including:

Clinical Trial Award (CTA)
Discovery Award (DA)
Focused Program Award (FPA)
Investigator-Initiated Research Award (IIRA)
Lifestyle and Behavioral Health Interventions Research Award (LBIRA)
Technology/Therapeutic Development Award (TTDA)

Application deadlines vary, but generally, the pre-applications are due between March 29 and April 19, 2023, depending on the mechanism.

Research Grants and Awards

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Current Students

Half-million-dollar grant will create peer review and science communication curriculum for grad students

By Elise Proulx
3 min. read ▪ Published August 29
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The ability to critically evaluate scientific literature is crucial for graduate students as they start their careers in science.

However, a lack of systematic training can hamper students’ future ability to review the work of others in their field.

“Reviewing scientific literature and analyzing literature is a huge part of graduate student education,” says Sarah Klass , a postdoctoral fellow in the Keasling Lab at UC Berkeley and the Joint Bioenergy Institute and the lead recipient of a $499,992, two-year grant from the National Science Foundation (NSF). “But there’s no formal education” on how to do it, Klass continues.

To attempt to remedy this disconnection, Klass and her partners will use the NSF grant to fund a new curriculum that will immerse graduate students in the sciences in the “principles and practices of peer review and science communication with a heavy emphasis on building practical skills.” Peer review is the system in which multiple experts review scientific papers to ensure quality before publication.

The team will spend the first year developing a curriculum. The second year, UC Berkeley grad students will put it to the test. The grant team, which will also include UC Berkeley School of Public Health professor Stefano M. Bertozzi and a to-be-determined team of UC Berkeley graduate students, will collect data on impact and effectiveness.

The proposed curriculum builds upon the success that the journal Rapid Reviews\Infectious Diseases ( RR\ID ) has had in making rigorous peer review faster and more efficient, partially by training UC Berkeley undergraduate students. RR\ID is an open-access journal that prioritizes rapid and efficient peer review alongside offering student training and mentoring and supporting the democratization of academic publishing through partnerships with a dozen academic institutions in low- and middle-income countries that will be established over the next three years. Bertozzi is the journal’s editor-in-chief

“As part of UC Berkeley Undergraduate Research Apprentice Program, RR\ID editors have offered a workshop allowing undergraduates to participate in research projects with faculty members for academic credit, focusing on topics of special interest,” the grant application reads. “The aim is to familiarize undergraduate students with contemporary scientific and academic research, peer review processes, and publication standards, particularly concerning infectious diseases.”

The new curriculum project will pilot a curriculum for a training program that will initially involve STEM graduate students enrolled at UC Berkeley, specializing in a broad spectrum of fields related to infectious diseases, data science, public health, engineering, and basic biological and chemical sciences. “By providing graduate students with the necessary tools and insights to critically evaluate scientific literature and review preprints, our goal is to improve graduate student research/literature comprehension and engagement with their respective STEM fields,” the team said.

“We are trying to teach good peer review skills to graduate students so they can help enable the rapid dissemination of scientifically vetted literature that can have an immediate impact on people’s lives,” says Klass.

“Above all, the intellectual discourse that needs to happen around science is closed off and isolated,” says Hildy Fong Baker, executive director of the UC Berkeley Center for Global Public Health and managing director of the project. “We are creating an avenue for people to be part of an ecosystem at the beginning of their careers.”

The course materials created during the two-year grant period will eventually be available to all via open access to encourage other institutions to adopt and adapt the curriculum worldwide.

People of BPH found in this article include:

Stefano Bertozzi Professor, Health Policy and Management

More in category “School News”:

Meet our new faculty: carly strouse, meet our new faculty: xiudi li, alum melissa stafford jones on her career developing meaningful policy approaches in public health, uc berkeley school of public health welcomes inaugural cohort of impact fellows.

CIRM Awards $67.5 Million to Address Neuropsychiatric Diseases through its ReMIND Program

FOR IMMEDIATE RELEASE

Contact: Koren Temple-Perry Sr. Director, Marketing & Communications [email protected]

South San Francisco, CA, August 30, 2024 – The California Institute for Regenerative Medicine, one of the world’s largest institutes dedicated to regenerative medicine, approved $67.5 million to support five projects in the Agency’s pilot ReMIND (Research using Multidisciplinary, Innovative Approaches in Neuro Diseases) Program.

ReMIND is a new initiative designed to accelerate the discovery of mechanisms underlying neuropsychiatric disorders leading to the identification and validation of novel targets and biomarkers. The goal is to provide new avenues and rigorous foundations for future translational and clinical investigations. To achieve this, the ReMIND Program will catalyze innovative, cross-disciplinary collaborations and support broad knowledge-sharing among research scientists and other stakeholders.

The program includes two distinct and separate funding opportunities. The awards correspond to the first, DISC4/ReMIND-L that has been designed to support large collaborative multidisciplinary projects cross-disciplinary, and integrated studies led by large collaborative teams applying a range of technologies and approaches. Five ReMIND-L awards were approved at CIRM’s August Independent Citizens’ Oversight Committee (ICOC) meeting:


DISC4-16295	Translational epigenomics: dissecting cell type-specific function of neuropsychiatric risk genes in vivo	Jin, Xin — Scripps Research	$11,376,314
DISC4-16285	Deep phenotyping of human brain organoid models of autism spectrum disorder to unravel disease heterogeneity and develop biomarkers and treatments	Pollen, Alex — UCSF	$12,297,272
DISC4-16377	Modeling the genetic basis of psychopathology in schizophrenia and autism	Sebat, Jonathan — UCSD	$12,703,708
DISC4-16322	CIRM Center for Neuropsychiatric Stem Cell Proteomics	Nowakowski, Tomasz — UCSF	$13,781,522
DISC4-16292	Multiomic Studies of Idiopathic Intellectual Disability and Autism Spectrum Disorder (ID/ASD)	Lipton, Stuart A — Scripps Research	$17,365,387

$12 Million Awarded to Uncover Genetic Pathways in Autism

A $12 million award to a team of investigators led by Alex Pollen, PhD, Assistant Professor of Neurology at the University of California, San Francisco (UCSF) will enable collaboration between various QB3 investigators across several institutions including David Schaffer, PhD, and Helen Bateup, PhD, from the UC Berkeley; Martin Kampmann, PhD, Saul Kato, PhD, and Elliott Sherr, PhD, at UCSF; and Mo Mostajo-Radji, PhD, Sofie Salama, PhD, and Mircea Teodorescu, PhD, at UC Santa Cruz.

The research team will uncover pathways through which autism spectrum disorder (ASD) mutations cause disease. The project will create 3D brain models in the lab to understand how different factors contribute to ASD and why certain populations are protected from developing the condition. By leveraging advanced AI to analyze clinical data, the research team will identify novel genetic modifiers and biomarkers associated with ASD.

“Our QB3 team of investigators across UCSF, UC Berkeley, and UC Santa Cruz will combine clinical data, 3D brain organoid models, analysis of genetic risk factors, genome engineering screens, and advanced AI tools to find common pathways, protective factors, and biomarkers for different forms of autism. This project could greatly advance our understanding of autism and lay the groundwork for new treatments,” said Dr. Pollen.

This research comes at a time when more than 1 in 22 children in California are diagnosed with autism, a neurological and developmental disorder that affects how people interact with others, communicate, learn, and behave.

“The project addresses a critical bottleneck in ASD research,” said Rosa Canet-Aviles, PhD, VP of Scientific Programs and Education at CIRM. “By uncovering the genetic underpinnings and developing new diagnostic tools, this project could pave the way for more precise and effective interventions, offering hope to countless families affected by ASD.”

About the California Institute for Regenerative Medicine (CIRM)

At CIRM, we never forget that we were created by the people of California to accelerate stem cell treatments to patients with unmet medical needs, and act with a sense of urgency to succeed in that mission. To meet this challenge, our team of highly trained and experienced professionals actively partners with both academia and industry in a hands-on, entrepreneurial environment to fast track the development of today’s most promising stem cell technologies.

With $5.5 billion in funding and more than 150 active stem cell programs in our portfolio, CIRM is one of the world’s largest institutions dedicated to helping people by bringing the future of cellular medicine closer to reality.

Major gift accelerates transformation of old mall into UCLA research hub

Dr. Gary Michelson and his wife Alya Michelson

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The reincarnation of a shuttered Los Angeles retail mecca as a sprawling UCLA research center has received a major boost from billionaire philanthropist Dr. Gary Michelson and his wife, Alya, who will give $120 million to ramp up the project.

Michelson, a spine surgeon and inventor, said the money will help launch the California Institute for Immunology and Immunotherapy, which aims to create breakthrough discoveries that prevent and cure diseases including cancer, heart disease and Alzheimer’s.

The institute will be a tenant in UCLA Research Park, which is under construction in the former Westside Pavilion. The indoor mall two miles south of the university at Pico and Westwood boulevards was a 1980s icon popular with shoppers and filmmakers before falling out of favor. Most of its stores closed by 2019.

The shopping center was being converted to offices when the UC Regents bought it for $700 million in January to create the research park. Along with the California Institute for Immunology and Immunotherapy, it will house the UCLA Center for Quantum Science and Engineering, as well as other science and medicine programs.

By purchasing the former shopping center, UCLA saved years of toil to build such a facility on its campus, which is the smallest of the nine UC undergraduate campuses and has very little room for growth.

Courtyard view of the new UCLA research center.

“That building would have gone on the last available piece of property on the UCLA campus,” Michelson said, “and it would have been extraordinarily expensive to build there. As a real estate matter, this was just an extraordinary opportunity.”

The immunology institute had been planned for years, while a full-scale research park was something “we’ve always dreamed of having ... but we always recognized we could never find a piece of property that big close to campus. We had sort of given up on the idea many years ago — and it came alive,” said former UCLA Chancellor Gene Block, who was instrumental in the purchase of the former Westside Pavilion.

An earlier plan to build the institute on the campus called for tearing down a parking garage, digging a hole deep enough to replace the parking and erecting a new building on top, Block said.

The gift, through the Michelson Medical Research Foundation , designates $100 million to establish two research entities within the institute, each funded with $50 million; one will focus on rapid vaccine development and the other on harnessing the body’s microbiome to advance human health. The microbiome research will be conducted in collaboration with the new UCLA Goodman-Luskin Microbiome Center , placing it among the largest microbiome research enterprises in the world, the foundation said.

The foundation is also funding a $20-million endowment to provide research grants to young scientists using novel processes to advance immunotherapy research, human immunology and vaccine discovery.

The institute will have labs of different sizes meant to serve biotech researchers who can start with small teams that can grow into larger labs if they find success.

“We’re going to create an entire ecosystem of biotech startups and they’re going to stay right here” and attract other players to the neighborhood, Michelson said. “We’re going to build out an entire ecosystem of biotech all through Westwood.”

He envisions 5,000 people, including 500 research scientists, working in the institute. Gov. Gavin Newsom estimated in January that it would take more than three years to fully transform the 700,000-square-foot complex, but Michelson hopes to have a large portion of the immunology institute operating in half that time, he said. At 360,000 square feet, the institute will be the research park’s primary tenant.

The former mall’s 12-screen multiplex movie theater may be converted into lecture halls or performance spaces offering programming across the arts, humanities, sciences and social sciences, the chancellor’s office said.

Interior view of the new UCLA Research Park.

The gift is the Michelsons’ largest single donation in 30 years of philanthropy that includes $50 million to build Michelson Hall at the University of Southern California, which is home to the Michelson Center for Convergent Bioscience. The Michelson name will not be attached to the new UCLA complex, he said, because other philanthropists — perhaps one who donates more than he did — may want the recognition.

“The gift will change countless lives here and across the globe,” UCLA interim Chancellor Darnell Hunt said.

The institute will operate as a nonprofit medical research organization funded by a public-private partnership and governed by an independent board that includes UCLA representatives, according to a UC Regents document . The institute will pay UCLA 7.5% of the net revenues generated by the sale of new medicines and other inventions its scientists create, the document said.

Los Angeles Mayor Karen Bass said the project “has the potential to fundamentally change health outcomes around the world and create good jobs in Los Angeles.”

The purchase of the former Westside Pavilion marked the third major acquisition for the public university system in Los Angeles in less than two years.

Seeking to expand its footprint, UCLA announced in June 2023 that it had acquired the Art Deco-style Trust Building in downtown Los Angeles and renamed it UCLA Downtown.

Nine months prior, the school spent $80 million to buy two other major properties owned by Marymount California University, a small Catholic university that was shuttered last year. The purchase included Marymount’s 24.5-acre campus in Rancho Palos Verdes and an 11-acre residential site in nearby San Pedro.

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NIH prize challenge recognizes undergraduate biomedical engineers for innovative medical device designs

The National Institutes of Health (NIH) and the higher education non-profit VentureWell have selected 11 winners and five honorable mentions in the Design by Biomedical Undergraduate Teams (DEBUT) Challenge , who are set to receive prizes totaling $160,000. The awards will be presented to the winning teams on Oct. 25, 2024, during the annual Biomedical Engineering Society conference in Baltimore.

Now in its 13th year, the annual DEBUT Challenge calls on teams of undergraduate students to identify healthcare problems and develop technological solutions. This unique partnership supports innovation and entrepreneurship training for students at a critical stage early in their careers.

“This year's competition drew tremendous student innovation from all DEBUT Challenge entrants,” said Bruce J. Tromberg, Ph.D., director of NIH's National Institute of Biomedical Imaging and Bioengineering (NIBIB). “We congratulate all the participants and their mentors on the impressive engineering designs and their passion for addressing compelling healthcare problems. DEBUT demonstrates the power of interdisciplinary teams coming together to deliver solutions to benefit patients.”

Hands supporting the handle of a transparent prototype ear canal scope

The innovative designs receiving NIBIB-sponsored awards include a system for monitoring post-operative bleeding in urologic cases, a real-time imaging probe of the ear canal to examine the health of middle ear structures and a device to aid cesarean section delivery during impacted fetal head complications.

Additional winners include the recipients of the prize sponsored by NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The winning team developed a powered lower limb prosthetic that provides assistive movement at the knee joint to promote a more natural walking gait and support in standing and climbing stairs .

A prosthetic lower leg with a running shoe and image of a person outfitted with the prosthetic and stepping on stairs

“Assistive and rehabilitative technologies such as the low-cost, adaptable, bionic knee developed by this year’s winning team can improve the quality of life for people with physical disabilities,” said Theresa Hayes Cruz, Ph.D., NICHD.

This year’s challenge included submissions from 85 teams, consisting of 362 students from 24 U.S. states. Along with the NIBIB, NICHD and VentureWell, five NIH partners supported the challenge this year with unique prizes: the NIH Office of AIDS Research (OAR), the National Institute on Minority Health and Health Disparities (NIMHD), the National Cancer Institute (NCI), the National Institute of Nursing Research (NINR) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

The 11 winning projects are:

NIBIB “Steven H. Krosnick” First Prize ($20,000): UroFlo: An automated and intuitive UTI and blood clot prevention device, Rice University, Houston

Hospital monitor displaying patient data under a hand poised to press a button

UroFlo is an adaptive, automated, intuitive continuous bladder irrigation system to improve post-operative assessment of hematuria (blood in the urine). UroFlo incorporates a spectral sensor to quantify hematuria, adjusts inflow rate automatically and quantifies waste bag outflow rate. A web-based, remotely accessible user interface consolidates data and alerts clinical staff to issues, such as abnormal flow rates, severe hematuria or the need to make a bag replacement.

NIBIB Second Prize ($15,000): OCTAVE: Optical coherence tomography and vibrometry endoscope, University of California, Riverside

OCTAVE is an endoscopic optical coherence tomography imaging probe that is capable of high-resolution, real-time, functional imaging of the middle ear structures. OCTAVE addresses a critical challenge in hearing loss detection by providing the capacity to image inner ear structures with high enough resolution to reveal specific sites of damage to the tympanic membrane.

NIBIB Third Prize ($10,000): Cesarean Delivery Glove, Northwestern University, Evanston, Illinois

The Cesarean Delivery Glove (CDG) is a cost-effective, reusable device that allows a single operator to safely and effectively resolve impaction of the fetal head within the mother’s pelvis during the cesarean section procedure. The CDG extends an obstetrician’s reach to provide sufficient force for extraction while minimizing risk of trauma to mother and baby.

NIH OAR Technologies for HIV/AIDS Prevention and Care Prize ($15,000): Infusion Pump Mobile Application, Loyola University Chicago

The Infusion Pump Mobile Application integrates seamlessly with the Baxter Novum IQ infusion pump to ensure accurate and efficient drug infusion in the intensive care unit environment. The app provides patient verification, barcode integration, delivery confirmation, real-time infusion progress monitoring, alert and alarm notifications and direct medication order transmission. Intravenous (IV) infusions can potentially be used for HIV treatment, including antiretrovirals and broadly neutralizing antibodies.

NIMHD Healthcare Technologies for Low-Resource Settings Prize ($15,000): NanoLIST, Cornell University, Ithaca, New York

NanoLIST is a rapid, low-cost test kit that utilizes gold nanoparticles to detect when a person’s saliva sample contains an elevated lead concentration. The test kit produces a result within 30 seconds. Its self-contained format is designed so a test can be safely performed without supervision by a clinician and for easy disposal.

NCI Technologies for Cancer Prevention, Diagnosis, or Treatment Prize ($15,000): ColoTech: A ‘pro-diagnostic’ for the early detection of colorectal dysplastic and cancerous tissue, Stanford University, Palo Alto, California

ColoTech is a novel, cost-effective screening tool for abnormal (dysplastic) cells and could aid in earlier colorectal cancer detection. ColoTech’s highly sensitive approach uses a probe ingested by the patient that changes chemical composition upon contact with abnormal or cancerous tissue and could be an alternative to colonoscopy.

National Center for Medical Rehabilitation Research, NICHD Rehabilitative and Assistive Technologies Prize ($15,000): U-Build Bionic Knee: Transfemoral powered prosthetic, University of Utah, Salt Lake City

The U-Build Bionic Knee is a low-cost, powered lower-extremity prosthesis designed to improve mobility and quality of life for individuals with lower-extremity amputation. The device generates assistive power at the knee joint, enabling ambulation on level ground, uneven terrain, and positive-power activities like sit-to-stand movement and stair ascent.

NINR Technologies to Empower Nurses in Community Settings Prize ($15,000): IV pole redesign, Virginia Polytechnic Institute and State University, Blacksburg

Intravenous (IV) poles are a staple of healthcare operations, but their current design makes visualizing medications difficult. IV Pole Redesign was built in collaboration with nurses and incorporates a tiered and angled hook rake top, an offset pole portion, a spider base, a line organizer, and wheels that improve mobility across threshold transitions.

NIDDK Kidney Technology Development Prize ($15,000): NephroGuard, Clemson University, South Carolina

Plastic tubing connected to the top of a liquid collection bag on a medical fabric surface

NephroGuard is a real-time diagnostic device to quickly detect onset of acute kidney injury in patients following cardiac surgery. NephroGuard uses an electrochemical sensor to detect a biomarker that has been shown to detect kidney injury within hours rather than days.

VentureWell Venture Prize ($15,000): Knee-sy Does It: Your therapy automation solution, Stevens Institute of Technology, Hoboken, New Jersey

Knee-sy Does It is a novel stretching device designed to replicate physical therapy treatment at home for patients suffering from knee osteoarthritis or recovering from knee surgery. Knee-sy Does It delivers a combination of dynamic and static stretches in a sequence similar to that which a physical therapist might administer in practice.

VentureWell Design Excellence Prize ($5,000): Malleous: A novel suction-retractor instrument to increase efficiency and effectiveness in the operating room, University of Pittsburgh

Malleous is a surgical instrument combining suction and ribbon retraction tools in one device while maintaining the retractor's malleable and bendable properties. By reducing the need to pause during surgery, the Malleous device reduces surgery duration, which has the potential to increase surgeons’ efficiency and reduce the risk of complications.

Learn more about the projects.

About the National Institute of Biomedical Imaging and Bioengineering (NIBIB): NIBIB’s mission is to engineer the future of health by leading the development and accelerating the application of biomedical technologies. The Institute is committed to integrating engineering and physical science with biology and medicine to advance our understanding of disease and its prevention, detection, diagnosis, and treatment. NIBIB supports emerging technology research and development within its internal laboratories and through grants, collaborations, and training. More information is available at the NIBIB website .

About the National Institutes of Health (NIH): The National Institutes of Health, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit https://www.nih.gov .

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CIRM Awards $67.5 Million to Address Neuropsychiatric Diseases through
$12 Million Awarded to Uncover Genetic Pathways in Autism . A $12 million award to a team of investigators led by Alex Pollen, PhD, Assistant Professor of Neurology at the University of California, San Francisco (UCSF) will enable collaboration between various QB3 investigators across several institutions including David Schaffer, PhD, and Helen Bateup, PhD, from the UC Berkeley; Martin ...
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NIH prize challenge recognizes undergraduate biomedical engineers for
The National Institutes of Health (NIH) and the higher education non-profit VentureWell have selected 11 winners and five honorable mentions in the Design by Biomedical Undergraduate Teams (DEBUT) Challenge, who are set to receive prizes totaling $160,000.The awards will be presented to the winning teams on Oct. 25, 2024, during the annual Biomedical Engineering Society conference in Baltimore.
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