medicinal chemistry research

Volume 32, Issue 7

Special Issue in Honor of Dr. Nicholas A. Meanwell on the Occasion of His Retirement from Bristol Myers Squibb

Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell

Reflections on a 40-year career in drug design and discovery

Future challenges and opportunities with fluorine in drugs?

Toxicology Modernization: Misnomer or Momentum

Successes in antiviral drug discovery: a tribute to Nick Meanwell

Acyl glucuronides–mediators of drug-induced toxicities?

C-C bond cleavage reactions catalyzed by cytochrome P450 enzymes

Harnessing the necessary nitrogen atom in chemical biology and drug discovery

The rise of targeting chimeras (TACs): next-generation medicines that preempt cellular events

A guide for the synthesis of key nucleoside scaffolds in drug discovery

Targeting MDM2 for the development of a new cancer therapy: progress and challenges

The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents

Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain

Synthetic studies toward a simplified eleuthoside core

SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole

Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors

Novel potent and highly selective DDR1 inhibitors from integrated lead finding

Structure-based optimization of aminothiadiazole inhibitors of AKT

Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406

Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis

A versatile strategy for the synthesis of various lumazine peptides

Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env

Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an O lp →π* Ar interaction

Direct syntheses of stereoisomers of 3-fluoro GABA and β -fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendiline and NPS R-467