research grant proposal

An official website of the United States government

Official websites use .gov A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Publications
Account settings
Advanced Search
Journal List

How to write a successful grant application: guidance provided by the European Society of Clinical Pharmacy

Anita e weidmann, cathal a cadogan, daniela fialová, ankie hazen, martin henman, monika lutters, betul okuyan, vibhu paudyal, francesca wirth.

Author information
Article notes
Copyright and License information

Corresponding author.

Received 2022 Sep 25; Accepted 2023 Jan 12; Issue date 2023.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .

Considering a rejection rate of 80–90%, the preparation of a research grant is often considered a daunting task since it is resource intensive and there is no guarantee of success, even for seasoned researchers. This commentary provides a summary of the key points a researcher needs to consider when writing a research grant proposal, outlining: (1) how to conceptualise the research idea; (2) how to find the right funding call; (3) the importance of planning; (4) how to write; (5) what to write, and (6) key questions for reflection during preparation. It attempts to explain the difficulties associated with finding calls in clinical pharmacy and advanced pharmacy practice, and how to overcome them. The commentary aims to assist all pharmacy practice and health services research colleagues new to the grant application process, as well as experienced researchers striving to improve their grant review scores. The guidance in this paper is part of ESCP’s commitment to stimulate “ innovative and high-quality research in all areas of clinical pharmacy ”.

Keywords: Clinical pharmacy , Economics, Funding, Grants, Peer review, Writing

Writing research grants is a central part of any good quality research. Once a detailed research proposal has been submitted, it is subjected to an expert peer review process. Such reviews are designed to reach a funding decision, with feedback provided to improve the study for this and any future submissions. Depending on the length of the proposal, complexity of the research and experience of the research team, a proposal can take between six to twelve months to write [ 1 ]. Ample time must be given to the writing of hypothesis/research aim, budgeting, discussion with colleagues and several rounds of feedback [ 2 ]. The draft research proposal should always be completed well before the deadline to allow for last minute delays. An application which is not fully developed should not be submitted since it will most likely be rejected [ 3 ].

Despite the large effort that goes into each grant application, success rates are low. Application success rates for Horizon 2020 were < 15% [ 4 ] and < 20% for the National Institute of Health (NIH) [ 5 – 8 ]. With these statistics in mind, it is evident that often repeated submissions are required before securing funding. Due to a paucity of specific clinical pharmacy grant awarding bodies, writing a grant application for a clinical pharmacy or pharmacy practice research project often involves multidisciplinary collaborations with other healthcare professions and focus on a specific patient population or condition. There is no guarantee of success when trying to secure funding for research. Even the most seasoned researchers will have applications rejected. The key is to never give up. This commentary provides useful pointers for the planning and execution of grant writing.

Conceptualising your research idea

Before writing a research grant proposal/application, consider what the research should achieve in the short, medium, and long term, and how the research goals will serve patients, science and society [ 9 , 10 ]. Practical implications of research, policy impact or positive impact on society and active patient/public involvement are highly valued by many research agencies as research should not be conducted “only for research”, serving the researchers’ interests. EU health policy and action strategies (CORDIS database) and other national strategies, such as national mental health strategy for grants within mental disorders, should be considered, as well as dissemination strategies, project deliverables, outcomes and lay public invitations to participate. The Science Community COMPASS has developed a useful “Message Box Tool” that can help in the identification of benefits and solutions, as well as the all-important “So What?” of the research [ 11 ]. Clearly determine what the lead researcher’s personal and professional strengths, expertise and past experiences are, and carefully select the research team to close these gaps [ 12 – 14 ].

How to find the right funding call

When trying to identify the right type of grant according to the research ambitions, one should be mindful that several types of grants exist, including small project grants (for equipment, imaging costs), personal fellowships (for salary costs, sometimes including project costs), project grants (for a combination of salary and project costs), programme grants (for comprehensive project costs and salary for several staff members), start-up grants and travel grants [ 15 ]. Types of grants include EU grants (e.g. Horizon, Norway Grant), commercial grants (e.g. healthcare agencies and insurance companies), New Health Program grants ideal for new, reimbursed clinical pharmacy service projects and national grants (e.g. FWF (Austria), ARRS (Slovenia), NKFIH (Hungary), NCN (Poland), FWO (Belgium), HRZZ (Croatia), GAČR (Czech Republic), SNSF (Switzerland), SSF (Sweden). It is worth remembering that early career researchers, normally within ten years of finishing a PhD, have a particular sub-category within most grants.

Many national agencies only have one “Pharmacy” category. This results in clinical pharmacy and advanced clinical pharmacy practice projects competing with pharmaceutical chemistry, pharmaceutical biology and pharmacy technology submissions, thereby reducing the success rate as these research areas can often be very advanced in most EU countries compared to clinical and advanced pharmacy practice. A second possible submission category is “Public Health”. Several essential factors can impact the grant selection, such as research field, budget capacity, leading researcher’s experience and bilateral grants. Examples of successful clinical pharmacy funded research studies can be found in the published literature [ 16 – 20 ].

Plan, plan, plan

One key element of successful grant writing is the ability to plan and organise time. In order to develop a realistic work plan and achieve milestones, it is imperative to note deadlines and to be well-informed about the details of what is required. The development of a table or Gantt Chart that notes milestones, outcomes and deliverables is useful [ 21 ].

All funders are quite specific about what they will and will not fund. Research your potential funders well in advance. It is vital to pay attention to the aims, ambitions and guidelines of the grant awarding bodies and focus your proposal accordingly. Submitting an application which does not adhere to the guidelines may lead to very early rejection. It is helpful to prepare the grant application in such a way that the reviewers can easily find the information they are looking for [ 15 , 22 ]. This includes checking the reviewers’ reports and adding “bolded” sentences into the application to allow immediate emphasis. Reviewers’ reports are often available on the agencies’ websites. It is extremely useful to read previously submitted and funded or rejected proposals to further help in the identification of what is required in each application. Most funding agencies publish a funded project list, and the ‘Centre for Open Science (COS) Database of Funded Research’ enables tracking of funding histories from leading agencies around the world [ 23 ]. Another useful recommendation is to talk to colleagues who have been successful when applying to that particular funder. Funding agency grant officers can provide advice on the suitability of the proposal and the application process.

It is important to pay particular attention to deadlines for the grant proposal and ensure that sufficient time is allocated for completion of all parts of the application, particularly those that are not fully within one’s own control, for example, gathering any required signatures/approvals. Funders will generally not review an application submitted beyond the deadline.

Lastly, it is important to obtain insight into the decision process of grants. Research applications are sent to several reviewers, who are either volunteers or receive a small compensation to judge the application on previously determined criteria. While the judging criteria may vary from funder to funder, the key considerations are:

Is there a clear statement of the research aim(s)/research question(s)/research objective(s)?

Is the proposed research “state-of-the-art” in its field and has all relevant literature been reviewed?

Is the method likely to yield valid, reliable, trustworthy data to answer question 1.?

If the answer to the second question is ’yes’, then what is the impact of financing this study on patient care, professional practice, society etc.?

Is there sufficient confidence that the research team will deliver this study on time with expected quality outputs and on budget?

Does the study provide value for money?

How to write

The key to good grant proposal writing is to be concise yet engaging. The use of colour and modern web-based tools such as #hashtags, webpage links, and links to YouTube presentations are becoming increasingly popular to improve the interest of a submission and facilitate a swift decision-making process. Ensure use of the exact section headings provided in the guidance, and use the keywords provided in the funding call documentation to reflect alignment with the funding bodies’ key interests. Attention to detail cannot be overstated; the quality and accuracy of the research proposal reflect the quality and accuracy of the research [ 24 ]. Try to adopt a clear, succinct, and simple writing style, making the grant easy to read. Having a clear focus can help to boost a grant to the top of a reviewer’s pile [ 25 , 26 ]. A clearly stated scientific question, hypothesis, and rationale are imperative. The reviewer should not have to work to understand the project [ 27 ]. Allow for plenty of time to incorporate feedback from trusted individuals with the appropriate expertise and consider having reviews for readability by non-experts.

What to write

Abstract, lay summary and background/rationale.

Take sufficient time to draft the scientific abstract and summary for the lay public. These should clearly state the long-term goal of the research, the aim and specific testable objectives, as well as the potential impact of the work. The research aim is a broad statement of research intent that sets out what the project hopes to achieve at the end. Research objectives are specific statements that define measurable outcomes of the project [ 28 , 29 ].

The lay summary is important for non-subject experts to quickly grasp the purpose and aims of the research. This is important in light of the increased emphasis on patient and public involvement in the design of the research. The abstract is often given little attention by the applicants, yet is essential. If reviewers have many applications to read, they may form a quick judgement when reading the abstract. The background should develop the argument for the study. It should flow and highlight the relevant literature and policy or society needs statements which support the argument, but at the same time must be balanced. It should focus on the need for the study at the local, national and international level, highlighting the knowledge gap the study addresses and what the proposed research adds. Ensure this section is well-referenced. The innovation section addresses the ‘‘So what?’’ question and should clearly explain how this research is important to develop an understanding in this field of practice and its potential impact. Will it change practice, or will it change the understanding of the disease process or its treatment? Will it generate new avenues for future scientific study? [ 30 ].

Hypothesis/aims and objectives

For the hypothesis, state the core idea of the grant in one or two sentences. It should be concise, and lead to testable specific aims. This section is fundamental; if it is unclear or poorly written, the reviewers may stop reading and reject the application. Do not attempt to make the aims overly complex. Well-written aims should be simply stated. Criteria such as PICO (population, intervention, comparison, outcomes) [ 31 ], and FINER (feasible, interesting, novel, ethical, relevant) [ 32 ], provide useful frameworks to help in writing aim(s), research question(s), objective(s) and hypotheses. Pay attention to the distinction between aim(s), research question(s), objective(s) and hypotheses. While it is tempting to want to claim that enormously complex problems can be solved in a single project, do not overreach. It is important to be realistic [ 25 ].

Experimental design, methods and expertise

The methodology is one of the most important parts of getting a grant proposal accepted. The reviewing board should be convinced that the relevant methodology is well within the research teams’ expertise. Any evidence of potential success, such as preliminary results or pilot studies strengthen the application significantly [ 33 ]. The methodology must relate directly to the aim. Structuring this section into specific activities/ set of activities that address each research question or objective should be considered. This clarifies how each question/ objective will be addressed. Each work-package should clearly define the title of the research question/objective to be addressed, the activities to be carried out including milestones and deliverables, and the overall duration of the proposed work-package. Deliverables should be presented in table format for ease of review. Each subsequent work-package should start once the previous one has been completed to provide a clear picture of timelines, milestones and deliverables which reflect stakeholder involvement and overall organisation of the proposed project. Using relevant EQUATOR Network reporting guidelines enhances the quality of detail included in the design [ 34 ]. Key elements of this methodology are detailed in Table 1 .

Summary of the key elements of the experimental design, methods and expertise

Proposed budget

The budget should be designed based on the needs of the project and the funding agency’s policies and instructions. Each aspect of the budget must be sufficiently justified to ensure accountability to the grant awarding body [ 35 ]. Costing and justification of the time of those involved, any equipment, consumables, travel, payment for participants, dissemination costs and other relevant costs are required. The funders will be looking for value for money and not necessarily a low-cost study. Ensure that the total budget is within the allocated funding frame.

Provide a breakdown of the key work packages and tasks to be completed, as well as an indication of the anticipated duration. Include a Gantt chart (A table detailing the most general project content milestones and activities) to demonstrate that all aspects of the proposal have been well thought through [ 21 ].

Critical appraisal, limitations, and impact of the proposed research

It is important to detail any strengths and limitations of the proposed project. Omitting these will present the reviewing board with sufficient grounds to reject the proposal [ 36 ]. Provide a clear statement about the short and long-term impact of the research [ 37 , 38 ]. The reviewers will pay particular attention to the differences the study can make and how potential impact aligns with the funding bodies goals as well as national policies. This statement is essential to make an informed decision whether or not to support the application. Useful diagrams summarise the different levels of impact [ 39 ].

Table 2 provides a summary of the key elements of project grants and key questions to ask oneself.

Summary of the key elements of project grants and key questions to ask oneself.

(Adapted from [ 5 ]: Koppelmann GH, Holloway JW. Successful grant writing. Paediatr Respir Rev. 2012; 13:63–66.)

Although the grant writing process is time-consuming and complex, support is widely available at each stage. It is important to involve colleagues and collaborators to improve the proposal as much as possible and invest time in the detailed planning and execution. Even if the grant is not awarded, do not be disheartened. Use the feedback for improvement and exercise resilience and persistence in pursuing your research ambition.

The guidance in this paper is part of ESCP’s commitment to stimulate “innovative and high-quality research in all areas of clinical pharmacy”. In a previous ESCP survey, it was found that few opportunities for collaboration (especially for grant applications) was one of the key barriers for members towards conducting research [ 40 ]. ESCP promotes networking, which is essential for multi-centre grant applications, both among ESCP members and with other organisations as it recognises the need for “multi-centre research in all areas of clinical pharmacy both within countries and between countries or differing healthcare delivery systems”. ESCP is planning to relaunch its own research grant which was paused during the pandemic, and it is also planning to provide ESCP members with information about the research grants offered by other organizations. ESCP is exploring partnering with other organisations to develop research proposals in areas of common interest and, in the near future, it will ask its members about their research priorities. Taken together, these initiatives will inform ESCP’s research strategy and help it to formulate policies to address the challenges its members face.

Acknowledgements

Research works of Assoc. Prof. Fialová were also supported by the institutional program Cooperation of the Faculty of Pharmacy, Charles University.

Open access funding provided by University of Innsbruck and Medical University of Innsbruck. This work was conducted without external funding.

Conflicts of interest

The authors have not disclosed any competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

1. Devine EB. The art of obtaining grants. Am J Health-Syst Pharm. 2009;66(15):580–7. doi: 10.2146/ajhp070320. [ DOI ] [ PubMed ] [ Google Scholar ]
2. Arthurs OJ. Think it through first: questions to consider in writing a success grant application. Paediatr Radiol. 2014;44:1507–11. doi: 10.1007/s00247-014-3053-6. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
3. Elsevier Connect. 5 pitfalls to writing a wining grant application for your research. 2019. https://www.elsevier.com/connect/5-pitfalls-to-writing-a-winning-grant-application-for-your-research . Accessed 05 Dec 2022.
4. Best practice guidelines WASP (write a Scientific Paper): writing a research grant – 1, applying for funding. Early Hum Dev. 2018;127:106–8. doi: 10.1016/j.earlhumdev.2018.07.013. [ DOI ] [ PubMed ] [ Google Scholar ]
5. National Institute for Health (NIH). Success Rates: R01-Equivalent and Research Project Grants. 2022. https://report.nih.gov/nihdatabook/category/10 . Accessed 05 Dec 2022.
6. Deutsche Forschungsgemeinschaft (DFG). Processing Times and Success rates., 2021. https://www.dfg.de/en/dfg_profile/facts_figures/statistics/processing_times_success_rates/index.html . Accessed 05 Dec 2022.
7. Mervis J. Odds improve for winning NSF grants, but drop in applications troubles some observers. Science. 2022 doi: 10.1126/science.adc9471. [ DOI ] [ PubMed ] [ Google Scholar ]
8. Myklebust JP. Should the ERC be worried about its low success rate? University World News. 2021 https://www.universityworldnews.com/post.php?story=20210521093708482 Accessed 05 Dec 2022.
9. Koppelmann GH, Holloway JW. Successful grant writing. Paediatr Respir Rev. 2012;13:63–6. doi: 10.1016/j.prrv.2011.02.001. [ DOI ] [ PubMed ] [ Google Scholar ]
10. Kanji S. Turning your research idea into a proposal worth funding. Canadian J Hosp Pharm. 2015;68(6):458. doi: 10.4212/cjhp.v68i6.1502. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
11. COMPASS. The Message Box. 2022. https://www.compassscicomm.org/leadership-development/the-message-box/ . Accessed 05 Dec 2022.
12. Ebadi A, Schiffauerova A. How to receive more funding for your research? Get connected to the right people. PloS One. 2015;10(7):e0133061. doi: 10.1371/journal.pone.0133061. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
13. Laurent GJ. Getting grant applications funded: lessons from the past and advice for the future. Thorax. 2004;59(12):1010–1. doi: 10.1136/thx.2004.024182. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
14. Research funding. Vitae, realising the potential of researchers. Available at https://www.vitae.ac.uk/researcher-careers/pursuing-an-academic-career/research-funding Accessed 05 Dec 2022.
15. Wellcome Trust. 2022. https://wellcome.org/grant-funding . Accessed 05 Dec 2022.
16. McIntosh J, Alonso A, MacLure K, et al. Case study of polypharmacy management in nine European countries: implications for change management and implementation. PLOS One. 2018;13(4):e0195232. doi: 10.1371/journal.pone.0195232. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
17. de Godoi Rezende Costa Molino C, Chocano-Bedoya PO, Sadlon A. Prevalence of polypharmacy in community-dwelling older adults from seven centres in five european countries: a cross-sectional study of DO-HEALTH. BMJ Open. 2022;12:e051881. doi: 10.1136/bmjopen-2021-051881. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
18. Bhagavathula AS, Assen Seid M, Adane A, et al. Prevalence and determinants of Multimorbidity, Polypharmacy and potentially inappropriate medication use in older outpatients: Findindgs from EuroAgeism H2020 ESR7 Project in Ethiopia. Pharmaceuticals. 2021;14(9):844. doi: 10.3390/ph14090844. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
19. Watson MC, Ferguson J, Barton GR, et al. A cohort study of influences, health outcomes and costs of patients’ health-seeking behaviour for minor ailments from primary and emergency care settings. BMJ Open. 2015;5:e006261. doi: 10.1136/bmjopen-2014-006261. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
20. Patton DE, Pearce CJ, Cartwright M, et al. A non-randomised pilot study of the solutions for Medication adherence problems (S-MAP) intervention in community pharmacies to support older adults adhere to multiple medications. Pilot Feasibility Stud. 2021;7:18. doi: 10.1186/s40814-020-00762-3. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
21. Gantt.com. What is a Gantt chart. 2022. https://www.gantt.com . Accessed 05 Dec 2022.
22. Gholipour A, Lee EY, Warfield SK. The anatomy and art of writing a successful grant application: a pratical step-by-step approach. Pediatr Radiol. 2014;44:1512–7. doi: 10.1007/s00247-014-3051-8. [ DOI ] [ PubMed ] [ Google Scholar ]
23. Centre for Open Science. 2022. https://www.cos.io . Accessed 05 Dec 2022.
24. Liu JC, et al. Grant-writing pearls and pitfalls: Maximizing Funding Opportunities. Otolaryngol Head Neck Surg. 2016;154(2):226–32. doi: 10.1177/0194599815620174. [ DOI ] [ PubMed ] [ Google Scholar ]
25. Sohn E. Secrets to writing a winning grant. Nature. 2020;577:133–5. doi: 10.1038/d41586-019-03914-5. [ DOI ] [ PubMed ] [ Google Scholar ]
26. Powell K. The best-kept secrets to winning grants. Nat News. 2017;545:399. doi: 10.1038/545399a. [ DOI ] [ PubMed ] [ Google Scholar ]
27. McGee R. Keys to writing successful NIH research and career development grant applications. https://www.northwestern.edu/climb/resources/written-communication/Effective_NIH_Research_Career_Development_Proposals_Overview.pdf . Accessed 05 Dec 2022.
28. Anon. Developing Research Aims and Objectives. In: David R Thomas, Ian Hodges. Designing and Planning Your Research Project: Core Skills for Social and Health Researchers. Sage Publications. 2010. P. 38–47.
29. Farrugia P, Petrisor BA, Farrokhyar F, et al. Research questions, hypotheses and objectives. Can J Surg. 2010;53(4):278. [ PMC free article ] [ PubMed ] [ Google Scholar ]
30. University of York. Impact in research grant applications. 2022. https://www.york.ac.uk/staff/research/research-impact/impact-in-grants/ . Accessed 05 Dec 2022.
31. Schardt C, Adams MB, Owens T, et al. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Making. 2007;7:16. doi: 10.1186/1472-6947-7-16. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
32. Hulley SB, Cummings SR, Browner WS, et al. Designing Clinical Research. 3. Lippincott Williams & Wilkins; 2007. [ Google Scholar ]
33. Best practice guidelines WASP (write a Scientific Paper): writing a Research Grant – 2, Drafting the proposal. Early Hum Dev. 2018;127:109–11. doi: 10.1016/j.earlhumdev.2018.07.014. [ DOI ] [ PubMed ] [ Google Scholar ]
34. EQUATOR Network. Enhancing the QUAlity and Transparency Of health Research. 2022. https://www.equator-network.org/ . Accessed 05 Dec 2022.
35. Patil GP. How to plan and write a budget for research grant proposal? J Ayurveda Integr Med. 2019;10(20):139–42. doi: 10.1016/j.jaim.2017.08.005. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
36. UW-Madison Writing Center. Planning and Writing a Grant Proposal: The Basics. 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642360/ . Accessed 05 Dec 2022.
37. UK Research Impact. Research Excellence Framework. 2021. Available at https://re.ukri.org/research/ref-impact/ . Accessed 05 Dec 2022.
38. Hughes A, Kitson M, Bullock A, et al. The dual funding structure for research in the UK: research council and funding council 244 allocation methods and the pathways to impact of UK academics. Cambridge: Department of Innovation and Skills, UK Innovation Research Centre; 2013. [ Google Scholar ]
39. Research Councils UK. Pathways to impact. Available at https://www.publicengagement.ac.uk/do-engagement/funding/pathways-impact#:~text=A%20clearly%20thought%20through%20and,our%20economic%20and%20social%20wellbeing . Accessed 05 Dec 2022.
40. Stewart D, Paudyal V, Cadogan C, et al. A survey of the European society of clinical pharmacy members’research involvement, and associated enablers and barriers. Int J Clin Pharm. 2020;42(4):1073–87. doi: 10.1007/s11096-020-01054-9. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
View on publisher site
PDF (549.1 KB)
Collections