hot topics in dermatology research

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Insights in Dermatology: 2021

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We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Dermatology. Frontiers has organized a series of Research Topics to highlight the latest ...

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Hot Topics in Skincare From AAD 2023

Experts in dermatology discuss hot topics in skin care from AAD 2023 relating to skin renewal, photoprotection in patients with skin of color, next generation cleansing technologies, and the use of over the counter and prescription acne products.

EP. 1: Insights into the Burden of Acne and Role of Over-the-Counter Products

Joshua Zeichner, MD discusses the burden of acne in his patients and provides his best practices for setting and managing treatment expectations with over the counter and prescription treatment options in between sessions at AAD.

EP. 2: Practice Pearls for Combination Treatment with Over the Counter and Prescription Acne Medication

An expert in dermatology shares practice pearls at AAD for how to combine both over the counter and prescription acne medications in those patients suffering from acne.

EP. 3: Expert Perspectives on the Role of Tinted Sunscreens and Visible Light Protection

Amy McMichael, MD shares her insights on the role of tinted sunscreens for patients with darker skin tones, and discusses the need to protect against UVA, UVB, and visible light in between sessions at AAD.

EP. 4: Sun Protection in Patients With Skin of Color

An expert in dermatology shares her thoughts at AAD on the sun protection needs in her patients with skin of color; highlighting the role of the Fitzpatrick skin type scale and compounds such as vitamin E and antioxidants.

EP. 5: Insights into Gentle Cleansing and Hydrophobically-Modified Polymers

Patricia Farris, MD, discusses the importance of gentle cleansing techniques and hydrophobically modified polymers, highlighting their role in patients with sensitive skin in between sessions at AAD.

EP. 6: Efficacy of Hydrophobically-Modified Polymers and Green Cleansing Technologies

An expert in dermatology shares her thoughts on the role and efficacy of hydrophobically-modified polymers and green cleansing technologies comparing them to more traditional methods at AAD.

EP. 7: Expert Perspectives into Skin Renewal and Regeneration

Ted Lain, MD, MBA, comments on the rise of skin renewal research, cosmeceuticals, and tailored skin care regimes in between sessions at AAD.

EP. 8: A Conversion Around Hot Topics in Skin Renewal

An expert in dermatology shares his insights into some hot topics in skin renewal and highlights the utility of retinols in this arena.

EP. 9: Innovative Skin Care Pearls From AAD

In Dermatology Times®’ most recent Expert Perspectives series, Hot Topics in Skin Care in 2023, skin care experts met at the 2023 American Academy of Dermatology Annual Meeting to discuss their best treatment pearls.

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Conference Co-Chair/Presenter

Linda F. Stein Gold, MD

Director of Dermatology Clinical Research Henry Ford Health System Detroit, Michigan Brooklyn, New York

Disclosure: Linda F. Stein Gold, MD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: AbbVie; Amgen, Inc.; Arcutis Biotherapeutics, Inc.; Bristol-Myers Squibb Company; Dermavant Sciences; Eli Lilly and Company; LEO Pharma; Pfizer, Inc.; Ortho Dermatologics; UCB Pharma, Inc.    Served as a speaker or a member of a speakers bureau for: Amgen, Inc.; Pfizer, Inc.; Ortho Dermatologics  Received grants for clinical research from: AbbVie; Amgen, Inc.; Arcutis Biotherapeutics, Inc.; Dermavant Sciences; Eli Lilly and Company; LEO Pharma; Pfizer, Inc.; Ortho Dermatologics; UCB Pharma, Inc.

Session Co-Chairs/Presenters

Michael S. Kaminer, MD

Associate Clinical Professor of Dermatology​ Yale Medical School​ Adjunct Assistant Professor of Dermatology​ Brown Medical School​ SkinCare Physicians, Inc​ Chestnut Hill, Massachusetts

Disclosure: Michael S. Kaminer, MD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Allergan, Inc.; Arctic Fox Biomedical, Inc.; Candesant Biomedical; Endo Pharmaceuticals; Galderma Laboratories, L.P.; NC8; Soliton Received grants for clinical research from: Arctic Fox Biomedical, Inc.; Candesant Biomedical; Galderma Laboratories, L.P.; NV8; Soliton Owns stock, stock options, or bonds from: Artic Fox; Soliton Other: Soliton

Arisa Ortiz, MD

Associate Professor of Dermatology​ Director, Laser & Cosmetic Dermatology​ University of California, San Diego​ School of Medicine​ San Diego, California

Disclosure: Arisa Ortiz, MD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Alastin; Allergan, Inc.; Cutera; R2 Served as a speaker or a member of a speakers bureau for: Allergan, Inc.; Aerolase; BTL; Sofwave; Sciton Received grants for clinical research from: Allergan, Inc.; Revance

Hilary E. Baldwin, MD

Clinical Associate Professor Department of Dermatology Rutgers Robert Wood Johnson Medical Center New Brunswick, New Jersey Medical Director The Acne Treatment and Research Center Brooklyn, New York

Disclosure: Hilary E. Baldwin, MD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Almirall Hermal GmbH; Bausch & Lomb Inc.; EPI; Dr. Reddy’s Lab; Galderma Laboratories, L.P.; Sun Pharmaceutical Industries, Ltd.; Vyne  Served as a speaker or a member of a speakers bureau for: Almirall Hermal GmbH; Bausch & Lomb Inc.; EPI; Dr. Reddy’s Lab; Galderma Laboratories, L.P.; Sun Pharmaceutical Industries; Ltd.; Vyne  Received grants for clinical research from: Almirall Hermal GmbH; Bausch & Lomb Inc.; EPI; Dr. Reddy’s Lab; Galderma Laboratories, L.P.; Sun Pharmaceutical Industries, LTD; Vyne 

Sabrina G. Fabi, MD, FAAD, FAACS

Volunteer Assistant Clinical Professor University of California   Associate, Cosmetic Laser Dermatology​ San Diego, California

Disclosure: Sabrina G. Fabi, MD, FAAD, FAACS, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Allergan, Inc.; Bausch Health; Endo Pharmaceuticals; Galderma Laboratories, L.P.; Merz Pharmaceuticals; NCB Served as a speaker or a member of a speakers bureau for: AbbVie; Bausch Health; Galderma Laboratories, L.P.; Merz Pharmaceuticals; Revance Received grants for clinical research from: Allergan, Inc.; Bausch Health; Endo Pharmaceuticals; Galderma Laboratories, L.P.; Merz Pharmaceuticals; NCB; Revance; Teoxane Owns stock, stock options, or bonds from: Allergan, Inc.; Revance

Julie C. Harper, MD

Clinical Associate Professor of Dermatology University of Alabama-Birmingham School of Medicine President Dermatology and Skin Care Center of Birmingham Birmingham, Alabama

Disclosure: Julie C. Harper, MD, has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Almirall Hermal GmbH; BioPharmX; Cutera; Cutanea; Dermata; EPI; Galderma Laboratories, L.P.; LaRoche Posay; Ortho Dermatologics; Sol-Gel; Sun Pharmaceutical Industries, Ltd.; Vyne Served as a speaker or a member of a speakers bureau for: Almirall Hermal GmbH ; EPI; Galderma Laboratories, L.P.; Ortho; Vyne

Meghan Coulehan, MPH

Senior Director, Content Development, Medscape, LLC 

Disclosure: Meghan Coulehan, MPH, has disclosed no relevant financial relationships.  

CME Reviewer

Esther nyarko, pharmd.

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosure: Esther Nyarko, PharmD, has disclosed no relevant financial relationships.

Nurse Planner

Stephanie corder, nd, rn, chcp.

Disclosure: Stephanie Corder, ND, RN, CHCP, has disclosed no relevant financial relationships.

None of the nonfaculty planners for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

Hot Topics in Dermatology: A Year in Review

• Authors: Moderators: Linda F. Stein Gold, MD; Michael S. Kaminer, MD; Arisa Ortiz, MD; Panelists: Hilary E. Baldwin, MD; Sabrina G. Fabi, MD, FAAD, FAACS; Julie C. Harper, MD

CME / CE Released: 10/19/2021

• THIS ACTIVITY HAS EXPIRED FOR CREDIT

Valid for credit through: 10/19/2022 , 11:59 PM EST

Target Audience and Goal Statement

This activity is intended for dermatologists, allergists/clinical immunologists, pediatricians, plastic surgeons and aesthetic medicine specialists, rheumatologists, primary care physicians, nurse practitioners, and physician assistants involved in the care of patients with dermatologic conditions.

The goal of this activity is to increase clinicians’ awareness on expert perspectives and recent evidence on acne and rosacea treatments, as well as aesthetic dermatology.

Upon completion of this activity, participants will:

• Expert perspectives and recent evidence on acne and rosacea treatments
• Expert perspectives and recent evidence on aesthetic dermatology interventions

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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board. This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™ , you must receive a minimum score of 70% on the post-test. Follow these steps to earn CME/CE credit*:

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The View on Aesthetics: Hot Topics

The view on medical dermatology: hot topics in acne and rosacea, pre-assessment survey.

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The educational activity presented above may involve simulated, case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient, whether living or deceased, is intended or should be inferred. The material presented here does not necessarily reflect the views of Medscape, LLC, or any individuals or commercial entities that support companies that support educational programming on medscape.org. These materials may include discussion of therapeutic products that have not been approved by the US Food and Drug Administration, off-label uses of approved products, or data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. Readers should verify all information and data before treating patients or employing any therapies described in this or any educational activity. A qualified healthcare professional should be consulted before using any therapeutic product discussed herein.

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Posts are written by library staff and reflect their personal opinions not necessarily those of MSK.

Hot Topics in Skin Cancer Research and Treatment

Two recent articles about skin cancer feature MSK researchers.

The first, The Atlantic piece “ AI-Driven Dermatology Could Leave Dark-Skinned Patients Behind ,” discusses how researchers need to diversify the skin colors represented in image repositories being used to develop machine-learning algorithms that identify cancerous skin lesions. MSK dermatologist Dr. Allan C. Halpern states that the International Skin Imaging Collaboration, for which he is a spokesperson, is working to do just that.

The second, The New York Times article, “ Immunotherapy Drugs Slow Skin Cancer That Has Spread to the Brain ,” describes a recent study of 94 melanoma patients with tumors that spread to their brains. It found that two immunotherapy treatments given in combination, ipilimumab and nivolumab, reduced tumor size and prolonged life for many of the patients. The article quotes MSK’s Dr. Jedd Wolchok , who has already applied the findings to treating his own patients.

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• v.18(4); Fall 2014

Most Common Dermatologic Topics Published in Five High-Impact General Medical Journals, 1970–2012: Melanoma, Psoriasis, Herpes Simplex, Herpes Zoster, and Acne

Internists frequently diagnose herpes simplex, herpes zoster, and acne, which are also common dermatologic topics published. The authors conducted an independent search of the Thomson Reuters’ Science Citation Index for common dermatologic topics, limited to the period 1970 to 2012. The five most common dermatologic topics published in five high-impact general medical journals were melanoma, psoriasis, herpes simplex, herpes zoster, and acne.

General practitioners frequently encounter skin diseases and are accustomed to diagnosing the most common dermatologic conditions.

We sought to determine the most common dermatologic topics published in five high-impact general medical journals ( New England Journal of Medicine, The Lancet, the Journal of the American Medical Association, British Medical Journal (now The BMJ ), and Annals of Internal Medicine ).

We conducted an independent search of the Thomson Reuters’ Science Citation Index for common dermatologic topics, limited to the period 1970 to 2012.

Main Outcome Measure:

Total number of publications dealing with each dermatologic topic considered.

The five most common dermatologic topics published were melanoma, psoriasis, herpes simplex, herpes zoster, and acne. Melanoma and psoriasis were the top two dermatologic topics published in each journal except for Annals of Internal Medicine .

Conclusions:

Internists frequently diagnose herpes simplex, herpes zoster, and acne, which are also common dermatologic topics published. Although internists infrequently diagnose melanoma and psoriasis, they are major topics for general medical journals because of their increased community awareness, major advancements in therapeutic research, and their nondermatologic manifestations.

Introduction

Skin diseases are commonly encountered by general practitioners, and in today’s health care system, most patients are evaluated first by their primary care physician before seeing a dermatologist. It is estimated that 6% of primary care outpatient visits are skin-related, and 60% of cutaneous diagnoses are made by nondermatologists. 1 As the role of the general practitioner continues to grow, it remains imperative that these physicians are equipped to manage general dermatologic conditions.

To determine which skin diseases internists most commonly encounter, Feldman et al 2 analyzed the National Ambulatory Medical Care Survey data from 1990 to 1994. The top five dermatologic diagnoses made by internists during this period were dermatitis, bacterial skin infections, tinea, acne vulgaris, and herpes zoster. By highlighting these common diagnoses, it was anticipated that skin disease educational programs for internists would be tailored to these diseases. Moreover, this study demonstrated that diagnoses such as psoriasis, actinic keratosis, seborrheic keratosis, skin cancer, and benign tumors were commonly made by dermatologists but not by internists. These findings elucidated the overlapping yet differing role of the dermatologist and the internist, espousing the need for further communication and alliance in diagnosing a wide range of skin diseases.

The purpose of our study was to determine the most common dermatologic topics published from 1970 to 2012 in five high-impact general medical journals. We sought to analyze whether these journals, having the largest readership in medicine, targeted the common dermatologic diagnoses made by internists or focused on skin diseases more commonly diagnosed by dermatologists.

We analyzed data from the Thomson Reuters Science Citation Index. The five high-impact general medical journals we considered, based on the highest impact factors, were the New England Journal of Medicine (NEJM), The Lancet, the Journal of the American Medical Association (JAMA), British Medical Journal (now The BMJ ), and Annals of Internal Medicine. For each of these journals, we conducted an independent search for each of the dermatologic topics included in the study, limited to the years 1970 to 2012. The topics chosen were a modified list from the top dermatologic diagnoses made by internists and dermatologists 2 ( Table 1 ).

Total umber of articles for each dermatologic topic

Two independent reviewers analyzed search results to determine whether an article met the dermatologic topic under consideration. A consensus was achieved for all articles included. All types of publications (original research, case reports, review articles, meta-analyses, editorials, etc) were eligible for the study. If an article dealt with more than one possible topic, the topic that best fit the primary objective of the article was chosen. Topics without 20 or more papers in any of the 5 general medical journals were not mentioned.

A total of 2627 articles dealing with at least 1 of the 24 dermatologic topics mentioned in Table 1 were included in the study. From our combined data, the top 5 dermatologic topics published in the 5 high-impact general medical journals were melanoma (708 articles), psoriasis (455), herpes simplex (366), herpes zoster (253), and acne (165), as shown in Table 1 . The Lancet had the highest total number of dermatologic publications (744), followed by British Medical Journal (661), NEJM (630), JAMA (419), and Annals of Internal Medicine (173).

Melanoma was overwhelmingly the most common dermatologic topic in each of the journals except for Annals of Internal Medicine ( Figure 1 ). In NEJM, the second most common topic was psoriasis (100 articles), followed by herpes simplex (97) and herpes zoster (71). The other dermatologic topics were relatively uncommon in that journal. In The Lancet, the second most common topic was also psoriasis (144), followed by herpes simplex (102) and acne (49). There were also notable contributions to the dermatologic literature about herpes zoster (40), atopic dermatitis/eczema (40), urticaria (32), and abscess (28).

Frequency of common dermatologic topics mentioned in five high-impact general medical journals.

JAMA = Journal of the American Medical Association; NEJM = New England Journal of Medicine.

In JAMA, herpes simplex (with 68 articles) was the second most common dermatologic topic, followed by psoriasis (48) and herpes zoster (46). Acne (36), urticaria (30), and squamous cell carcinoma (22) followed in number of contributions. Melanoma (158) and psoriasis (134) were 2 greatly favored topics in the British Medical Journal. Herpes zoster (63), acne (60), and herpes simplex (56) made up the next highest proportion of topics, followed by abscess (35), urticaria (27), atopic dermatitis/eczema (26), and squamous cell carcinoma (22).

Annals of Internal Medicine was the only journal wherein melanoma (22) was not the most common dermatologic topic. In fact, melanoma was the fourth most prevalent. Preceding melanoma in prevalent articles was herpes simplex (43), herpes zoster (33), and psoriasis (29); see Figure 1 .

It has become customary for general practitioners to diagnose common skin conditions. For these physicians, primary sources for up-to-date information are general medical journals, namely the five high-impact journals ( NEJM, The Lancet, JAMA, British Medical Journal, and Annals of Internal Medicine ). By studying the prevalence of common dermatologic topics published in these journals, we attempted to provide insight into their emphasis on certain skin conditions.

Of the five high-impact general medical journals, we found that The Lancet and British Medical Journal, which have their foundation in the United Kingdom, published more articles on common dermatologic topics. In the United Kingdom, physicians must complete two years of foundation training and two years of core medical training before entering dermatology as a specialty. 3 This is in contrast to the US, where medical school graduates are required to complete only one year of internal medicine, general surgery, or pediatrics internship before entering dermatology residency. Perhaps in the United Kingdom, dermatology is integrated more with internal medicine, leading to a greater number of dermatologic publications in their general medical journals.

In our analysis, we found that herpes simplex, herpes zoster, and acne were three of the top five dermatologic topics published. This coincides with the fact that these topics were also among the top ten dermatologic diagnoses made by internists. 2 Melanoma and psoriasis, on the other hand, were the top two dermatologic topics published but are diagnoses rarely made by internists. 2

As mentioned by Feldman et al, 2 melanoma, despite being rarely diagnosed by internists, is important to internal medicine because of its serious nature. Some consider the early detection of melanoma, which has a 5-year survival rate of 98% if detected early and 15% with distant metastasis, 4 to be the responsibility of primary care physicians. 5 Furthermore, a “new era” of targeted and immune-based therapies for melanoma has been ushered in by recent advancements in melanoma research. 6 Many of these findings have gained publication in prestigious general medical journals. 7 – 9 It is not surprising, therefore, that melanoma was the most common dermatologic topic published in 4 of the 5 high-impact general medical journals we studied.

Psoriasis, like melanoma, is another diagnosis infrequently made by internists but was found in our study to be the second most common dermatologic topic published. With a prevalence of 1% to 3%, psoriasis is likely to be encountered by general practitioners. 10 Moreover, as a systemic inflammatory disease, psoriasis is compounded by psoriatic arthritis in 10% to 30% of cases. 10 Psoriasis has also been associated with a significantly increased risk of myocardial infarction, stroke, and peripheral vascular disease, possibly because of accelerated atherosclerosis in the setting of an inflammatory state. 11 These systemic manifestations, as well as the increasing prevalence of this dermatologic condition, make psoriasis a very relevant disease to internal medicine and the general medical journals. We acknowledge limitations in our study. Access to journal articles may have been limited by our university’s subscriptions, but all resources available were used to obtain articles. Certain articles that addressed multiple topics were categorized under one topic, considered the best fit by the reviewer. We referenced a study by Feldman et al, 2 who analyzed the National Ambulatory Medical Care Survey data from 1990 to 1994. Likely, diagnosing patterns of skin disease by internists may have changed since then, but to our knowledge, no similar analysis has yet been performed.

We believe our study achieved its primary purpose, to analyze the prevalence of common dermatologic topics published in high-impact general medical journals. We have demonstrated that certain dermatologic topics with increased relevance to internal medicine have greater numbers of publications. These findings are a testament to the value of these medical journals in providing relevant yet comprehensive information to general physicians, thus deserving the title of high-impact.

Acknowledgments

Kathleen Louden, ELS, of Louden Health Communications provided editorial assistance.

Disclosure Statement

Dr Wu received research funding from AbbVie, North Chicago, IL; Amgen Inc, Thousand Oaks, CA; Coherus Biosciences, Redwood City, CA; Eli Lilly, Indianapolis, IN; Merck, Whitehouse Station, NJ; and Pfizer, New York, NY, which were not directly related to this study. He is a consultant for AbbVie, North Chicago, IL; DUSA Pharmaceuticals Inc, Wilmington, MA; Eli Lilly, Indianapolis, IN; and Pfizer, New York, NY. Mr Choi and Mr Namavar have no conflicts of interest to disclose. No funding was received for this study.

• DOI: 10.1111/jdv.16152
• Corpus ID: 210195006

Hot topics in research and patient care in Dermatology and Venereology, 2019

• Published in Journal of the European… 1 January 2020

28 References

Non‐invasive imaging in dermatology and the unique potential of raster‐scan optoacoustic mesoscopy, the integration of dermoscopy and reflectance confocal microscopy improves the diagnosis of lentigo maligna, accuracy of dermoscopy in distinguishing erythroplasia of queyrat from common forms of chronic balanitis: results from a multicentric observational study, european task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period, position statement on atopic dermatitis in sub‐saharan africa: current status and roadmap, skin lesions, differential diagnosis and practical approach to potential survivors of torture, evaluation of a non‐ablative, fractional 1565 nm laser for the improvement of striae distensae albae, 2018 european guideline on the organization of a consultation for sexually transmitted infections, european guideline on the organization of a consultation for sexually transmitted infections, the microbiome of tunnels in hidradenitis suppurativa patients, related papers.

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New Medical Research

• Effect of adalimumab treatment on inflammatory and hematological parameters in patients with Hidradenitis suppurativa.
• Mechanistic basis for the translation inhibition of Cutibacterium acnes by Clindamycin.
• The role of piperacillin/tazobactam in the treatment of Hidradenitis suppurativa.
• A comparative exploration of immunohistochemical markers in patients with papulopustular rosacea undergoing treatment with oral isotretinoin versus doxycycline.
• Evaluation of post-surgical complications of hidradenitis suppurativa lesions explored with presurgical ultra-high frequency ultrasound mapping.
• Exploring the influencing factors on acne, melasma, and rosacea: A case-control study in China.
• Meibography health score: a simple grading system for isotretinoin-induced meibography alterations on patients with acne vulgaris.
• Investigation of the effect of adapalene 0.3%/benzoyl peroxide 2.5% gel in Korean patients with acne: a randomized, double-blind clinical trial, with a histopathological and immunohistochemical study.
• Study of different pre-treatments in the comparison of the efficacy of photodynamic therapy for moderate to severe acne vulgaris.
• Non-linear association between air pollutants and secondary sensitive skin in acne patients.
• Influence of Social Media and Internet on Treatment Decisions in Adult Female Acne Patients: A Cross-Sectional Survey Study.
• The Relationship between Chocolate Consumption and the Severity of Acne Lesions−A Crossover Study.

Clinical Reviews

• Diabetes remission associated with optimized treatment of hidradenitis suppurativa.
• Challenges in Adult Acne and the Role of Skin Care in Managing the Condition.
• Therapeutic strategies focusing on immune dysregulation and neuroinflammation in rosacea.
• Challenges to Prescribing Isotretinoin to Patients at a Safety Net Hospital Dermatology Clinic.

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Dermatological patients with itch report more stress, stigmatization experience, anxiety and depression compared to patients without itch: Results from a European multi-centre study

Affiliations.

• 1 Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
• 2 Institute of Medical Psychology, Justus-Liebig-University, Gießen, Germany.
• 3 Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway.
• 4 Department of Dermatology and Venereology, Skåne University Hospital, Malmo, Sweden.
• 5 Barts Health NHS Trust & Queen Mary University of London, London, UK.
• 6 Faculty of Social and Behavioural Sciences, Institute of Psychology, Unit Health, Medical and Neuropsychology, Leiden University, Leiden, The Netherlands.
• 7 Vitos Klinik, Gießen, Germany.
• 8 Faculty of Social and Health Sciences, Inland Norway University of Applied Sciences, Elverum, Norway.
• 9 Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal, Norway.
• 10 Clinical Epidemiology Unit, IDI-IRCCS, Rome, Italy.
• 11 Department of Psychology, University of Zaragoza, Zaragoza, Spain.
• 12 Aragon Psychodermatology Research Group Zaragoza, Zaragoza, Spain.
• 13 Department of Psychiatry, Amsterdam UMC, Location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
• 14 Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
• 15 Department of Dermatology, Medical University of Graz, Graz, Austria.
• 16 Clinique Notre Dame de Grâce, Gosselies, Belgium.
• 17 Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
• 18 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• 19 Department of Dermatology, University Hospital of Brest, Brest, France.
• 20 Institute of Psychology, University of Szeged, Szeged, Hungary.
• 21 School of Medicine, PHI University Clinic of Dermatology, University St Cyril and Methodius, Skopje, North Macedonia.
• 22 Radboud Institute for Health Sciences, Department of Medical Psychology, Radboud University Medical Centre, Nijmegen, The Netherlands.
• 23 Department of Dermatology, Stavanger University Hospital, Stavanger, Norway.
• 24 Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.
• 25 Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
• 26 Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Rzeszów, Poland.
• 27 Centre for Philosophy of Science of the University of Lisbon, Lisbon, Portugal.
• 28 Department of Dermatology, Coimbra Hospital and University Centre, Portugal.
• 29 University of Brest, Lien, France.
• 30 Central State Medical Academy of Department of Presidential Affairs, Moscow, Russia.
• 31 Medical Research and Educational Centre, Lomonosov Moscow State University, Moscow, Russia.
• 32 Department of Psychiatry and Psychosomatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
• 33 Department of Boundary Mental Conditions and Psychosomatic Disorders, Mental Health Research Centre, Moscow, Russia.
• 34 International Institute of Psychosomatic Health, Moscow, Russia.
• 35 Department of Dermatology, University Hospital Miguel Servet, Zaragoza, Spain.
• 36 Department of Dermatology, Skåne University Hospital, Malmö, Sweden.
• 37 Şişli Hamidiye Etfal Training and Research Hospital, Dermatology and Venereology Clinic, University of Health Sciences, Istanbul, Turkey.
• 38 South Wales Clinical Psychology Training Programme, Cardiff & Vale University Health Board & School of Psychology, Cardiff University, Cardiff, UK.
• PMID: 38468596
• DOI: 10.1111/jdv.19913

Background: Itch as the most common symptom in dermatology has been shown to be related to psychological factors such as stress, anxiety and depression. Moreover, associations were found between perceived stigmatization and itch. However, studies investigating the differences between patients with dermatoses with and without itch regarding perceived stress, stigmatization, anxiety and depression are missing. Therefore, one of the aims of the second study of the European Society for Dermatology and Psychiatry (ESDaP study II) was to investigate these relationships in a large cohort of patients with different itchy dermatoses.

Results: 3399 patients with 14 different itchy dermatoses were recruited at 22 centres in 17 European countries. They filled in questionnaires to assess perceived stigmatization, stress, signs of clinically relevant anxiety or depression, itch-related quality of life, the overall health status, itch duration, frequency and intensity. The most significant association between the severity of itching and the perception of stress was observed among individuals with rosacea (correlation coefficient r = 0.314). Similarly, the strongest links between itch intensity and experiences of stigmatization, anxiety, and depression were found in patients with seborrheic dermatitis (correlation coefficients r = 0.317, r = 0.356, and r = 0.400, respectively). Utilizing a stepwise linear regression analysis, it was determined that within the entire patient cohort, 9.3% of the variation in itch intensity could be accounted for by factors including gender, levels of anxiety, depression, and perceived stigmatization. Females and individuals with elevated anxiety, depression, and perceived stigmatization scores reported more pronounced itch intensities compared to those with contrary attributes.

Conclusion: This study underscores the connection between experiencing itch and its intensity and the psychological strain it places on individuals. Consequently, psychological interventions should encompass both addressing the itch itself and the interconnected psychological factors. In specific cases, it becomes imperative for dermatologists to direct individuals towards suitable healthcare resources to undergo further psychological assessment.

© 2024 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.

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Similar articles

• Symptom severity and psychological sequelae in rosacea: results of a survey. Böhm D, Schwanitz P, Stock Gissendanner S, Schmid-Ott G, Schulz W. Böhm D, et al. Psychol Health Med. 2014;19(5):586-91. doi: 10.1080/13548506.2013.841968. Epub 2013 Oct 3. Psychol Health Med. 2014. PMID: 24088195
• Perceived Stigmatization among Dermatological Outpatients Compared with Controls: An Observational Multicentre Study in 17 European Countries. Van Beugen S, Schut C, Kupfer J, Bewley AP, Finlay AY, Gieler U, Thompson AR, Gracia-Cazaña T, Balieva F, Ferreira BR, Jemec GB, Lien L, Misery L, Marron SE, Ständer S, Zeidler C, Szabó C, Szepietowski JC, Reich A, Elyas A, Altunay IK, Legat FJ, Grivcheva-Panovska V, Romanov DV, Lvov AN, Titeca G, Sampogna F, Vulink NC, Tomás-Aragones L, Evers AWM, Dalgard FJ; European Society for Dermatology and Psychiatry (ESDaP) Study collaborators. Van Beugen S, et al. Acta Derm Venereol. 2023 Jun 22;103:adv6485. doi: 10.2340/actadv.v103.6485. Acta Derm Venereol. 2023. PMID: 37345973 Free PMC article.
• Personality traits, depression and itch in patients with atopic dermatitis in an experimental setting: a regression analysis. Schut C, Bosbach S, Gieler U, Kupfer J. Schut C, et al. Acta Derm Venereol. 2014 Jan;94(1):20-5. doi: 10.2340/00015555-1634. Acta Derm Venereol. 2014. PMID: 23756579
• Itch Management: Psychotherapeutic Approach. Evers AW, Schut C, Gieler U, Spillekom-van Koulil S, van Beugen S. Evers AW, et al. Curr Probl Dermatol. 2016;50:64-70. doi: 10.1159/000446045. Epub 2016 Aug 23. Curr Probl Dermatol. 2016. PMID: 27578073 Review.
• Itch and Psyche: Bilateral Associations. Reszke R, Szepietowski JC. Reszke R, et al. Acta Derm Venereol. 2020 Jan 7;100(2):adv00026. doi: 10.2340/00015555-3346. Acta Derm Venereol. 2020. PMID: 31940046 Free PMC article. Review.
• Kopyciok ME, Stander HF, Osada N, Steinke S, Stander S. Prevalence and characteristics of pruritus: a one‐week cross‐sectional study in a German dermatology practice. Acta Derm Venereol. 2016;96(1):50–55.
• Stander S, Weisshaar E, Mettang T, Szepietowski JC, Carstens E, Ikoma A, et al. Clinical classification of itch: a position paper of the international forum for the study of itch. Acta Derm Venereol. 2007;87(4):291–294.
• Stander S, Schafer I, Phan NQ, Blome C, Herberger K, Heigel H, et al. Prevalence of chronic pruritus in Germany: results of a cross‐sectional study in a sample working population of 11,730. Dermatology. 2010;221(3):229–235.
• Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134(6):1527–1534.
• Torisu‐Itakura H, Anderson P, Piercy J, Pike J, Sakamoto A, Kabashima K. Impact of itch and skin pain on quality of life in adult patients with atopic dermatitis in Japan: results from a real‐world, point‐in‐time, survey of physicians and patients. Curr Med Res Opin. 2022;38(8):1401–1410.

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Chemical Society Reviews

Bioelectronics for electrical stimulation: materials, devices and biomedical applications.

* Corresponding authors

a Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China

b Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China E-mail: [email protected]

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat a broad spectrum of health conditions. Electrical stimulation (ES) is a pivotal technique in bioelectronics, offering a precise, non-pharmacological means to modulate and control biological processes across molecular, cellular, tissue, and organ levels. This method holds the potential to restore or enhance physiological functions compromised by diseases or injuries by integrating sophisticated electrical signals, device interfaces, and designs tailored to specific biological mechanisms. This review explains the mechanisms by which ES influences cellular behaviors, introduces the essential stimulation principles, discusses the performance requirements for optimal ES systems, and highlights the representative applications. From this review, we can realize the potential of ES based bioelectronics in therapy, regenerative medicine and rehabilitation engineering technologies, ranging from tissue engineering to neurological technologies, and the modulation of cardiovascular and cognitive functions. This review underscores the versatility of ES in various biomedical contexts and emphasizes the need to adapt to complex biological and clinical landscapes it addresses.

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Y. Huang, K. Yao, Q. Zhang, X. Huang, Z. Chen, Y. Zhou and X. Yu, Chem. Soc. Rev. , 2024, Advance Article , DOI: 10.1039/D4CS00413B

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Next Steps in Dermatology

Hot Tips for Procedures in Kids

Dermatologic procedures in children can be stressful for the patient, parent and the clinician. Next Steps in Derm, in partnership with ODAC Dermatology, Aesthetic & Surgical Conference , interviewed Dr. A. Yasmine Kirkorian, chief of dermatology at Children’s National Hospital. Watch as Dr. Kirkorian shares four hot tips for procedures in kids. Find out why you might want to reconsider some procedures. Hear how to involve the parent and why procedures are not a one-man job. Learn why obtaining assent is important. Plus Dr. Kirkorian shares when you might want to consider moving a procedure to the OR.

Further Reading

If you want to read more about pediatric dermatology, check out the following articles published in the Journal of Drugs in Dermatology:

Do the Words We Choose Matter When Prescribing Medications?

Background:  Caregivers are often apprehensive about treating childhood atopic dermatitis (AD) with topical corticosteroids but may find comfort if treatments are presented in a patient-centered manner.

Objective:  We assessed caregivers’ willingness to treat AD with either a “topical steroid,” “topical medication,” or “treatment, similar to the all-natural signals produced by the adrenal glands in the body.”

Methods:  A survey randomized 874 caregivers of children with AD to receive a “topical steroid,” “topical medication,” or “treatment, similar to the all-natural signals produced by the adrenal glands in the body.” A scenario-only dataset received these descriptions, while a descriptive heading dataset and expanded scale dataset also received headings of “Topical Steroid Use,” “Topical Medication Use,” and “All-Natural Treatment Use,” respectively. Responses were recorded on a 6-point Likert scale or 0-100 slider scale. Whole and dichotomized responses were evaluated using 2-tailed, independent sample t-tests.

Results:  For the descriptive heading and expanded scale datasets, those presented with a “topical medication” reported greater willingness to treat than those presented with a “topical steroid” and “all-natural treatment” in the descriptive heading dataset (P<0.05). For the dichotomized scenario-only dataset, those presented with a “treatment, similar to the all-natural signals produced by the adrenal glands in the body,” reported greater willingness than those presented with a “topical medication” (P<0.05).

Conclusion:  Initially presenting caregivers with a “topical medication” rather than a “topical steroid” may improve willingness to treat AD for some caregivers. However, tailoring the discussion to best fit caregivers’ understanding of treatment may be the most beneficial approach.

Diagnosis and Management of Pediatric Psoriasis: An Overview for Pediatricians

Pediatric psoriasis (PsO) and its associated comorbidities carry physical and psychosocial burdens in children and adolescents, which can negatively impact quality of life. However, features distinguishing pediatric PsO from eczema and other common inflammatory skin diseases may not be obvious to primary care providers, which may contribute to underrecognition and misdiagnosis. Accurate diagnosis of pediatric PsO is critical for managing the physical and psychological burdens associated with this disease. This review aims to support pediatricians with enough information to confidently diagnose pediatric PsO, assess associated physical and mental health comorbidities, and recommend first-line treatment options for children with mild to moderate PsO. To accomplish this, we provide information that distinguishes the appearance and symptoms of pediatric PsO from other common pediatric skin conditions. In addition, comorbidities and some of the mental health challenges associated with pediatric PsO are reviewed to help pediatricians provide appropriate care for patients in their clinical practice.

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Reversible 3d images displayed in light-activated material.

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A new material displays 3D images in real space, allowing them to be viewed by multiple people at different angles, without the use of specialised headsets. The material, in which images are reversibly printed using light, could find use in a number of areas, including art, medical imaging and architectural design.

Current 3D display methods tend to involve arrays of liquid crystals or multiple moving components, like rotating LEDs. Now, scientists in the US have developed A 3D display medium made from a single solid-state polymer. The material can be fashioned into a simple handheld device in which images can be printed, erased and even animated.

The team, led by Dartmouth College’s Ivan Aprahamian , embedded azo-BF 2 photoswitches, which change colour in response to light, into a polymer matrix.

Using different wavelengths of light, the material can be made to change reversibly from blue to red to purple. Using this technique, the researchers printed various images in a prototype device, including of a dog, a chess piece and Dartmouth Hall.

Next the researchers aim to expand the material’s colour range and to develop faster-switching kinetics within the azo-BF 2 photoswitches to enable real-time imaging.

Q Qi et al , Chem, 2024, DOI: 10.1016/j.chempr.2024.07.012

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Aging and Kidney Disease

Kidney disease can develop at any time, but those over the age of 60 are more likely than not to develop kidney disease. As people age, so do their kidneys.

According to recent estimates from researchers at Johns Hopkins University, more than 50 percent of seniors over the age of 75 are believed to have kidney disease. Kidney disease has also been found to be more prevalent in those over the age of 60 when compared to the rest of the general population.

"Many people don't realize that, as we age, we lose kidney function," said Beth Piraino, MD, National Kidney Foundation President. "Unfortunately, older Americans may not realize they are at increased risk until it is too late."

The National Kidney Foundation (NKF) urges everyone over the age of 60 to be screened for kidney disease. NKF recommends annual screening with a simple urine albumin test that checks for protein in the urine-the earliest sign of kidney damage-as well as a blood test for kidney function. In addition to seniors, NKF recommends that members of other high-risk groups, such as those with diabetes, high blood pressure, and/or a family history of kidney failure, also be screened annually.

Kidney disease often develops slowly with few symptoms, and many people don't realize they have it until the disease is advanced. Awareness of kidney disease, especially for those at risk, is the first step to preventing, or slowing the progression of kidney disease.

"Kidney damage can manifest as decreased kidney filtration or protein in the urine," said Morgan Grams, MD, PhD, of Johns Hopkins Bloomberg School of Medicine. "If this is recognized and evaluated by both patients and their physicians, then the risk of complications can be managed."

Kidney Disease Facts:

• Kidney disease kills more people each year than breast or prostate cancer.
• The National Kidney Foundation recommends annual kidney disease screening for anyone over the age of 60.
• Risk factors for kidney disease include: high blood pressure, diabetes, kidney stones, a family history of kidney failure, prolonged use of over-the-counter pain medications, and being over the age of 60.
• More than 37 Million Americans - 1 in 7 adults- have chronic kidney disease and most don't know it.
• Of the over 120,000 Americans on the national organ transplant waitlist, more than 98,000 await a life-saving kidney.