MD
Meeting the needs of diverse populations
Prof. Tadej Battelino (Slovenia)
MD, PhD
The MiniMed™ 780G System study in very young children with type 1 diabetes – First results from the LENNY study
Prof. Tali Cukierman-Yaffe (Israel)
MD, PhD
Using MiniMed 780G system in Pregestational Type 1 Diabetes
Dr. Pablo Mora (US)
MD
The MiniMed 780G system performance in people living with type 2 diabetes requiring insulin treatment
* The MiniMed™ 780G system has not been approved for use for children aged 2-6 years, pregnancy, or type 2 diabetes by the FDA or other regulatory bodies. 1 Battelino T, Danne T, Bergenstal RM, et al. Clinical targets for continuous glucose monitoring data interpretation: recommendations from the international consensus on time in range. Diabetes Care 2019; 42: 1593–603. 2 Benhalima K, Beunen K, Siegelaar SE, et al. Management of type 1 diabetes in pregnancy: update on lifestyle, pharmacological treatment, and novel technologies for achieving glycaemic targets. Lancet Diabetes Endocrinol 2023; 11: 490–508. 3 ElSayed NA, Aleppo G, Aroda VR, et al. 15. Management of diabetes in pregnancy: standards of care in diabetes—2023. Diabetes Care 2023; 46 (suppl 1): S254–66.
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1. set the stage.
Prepare the audience for what is to come. If the audience is composed of people of mixed expertise, spend a few minutes forming them into small mixed groups of novices and experts. Explain that this is an opportunity for the more junior to learn from the more senior people. Tell them that the case to be presented is extremely interesting, why it is so and what they may learn from it. The primary objective is to analyze the clinical reasoning that was used rather than the knowledge required, although the acquisition of such knowledge is an added benefit of the session. A “well organized case presentation or clinicopathological conference incorporates the logic of the workup implicitly and thus makes the diagnostic process seem almost preordained”.
A psychiatry resident began by introducing the case as an exciting one, explaining the process and dividing the audience into teams mixing people with varied expertise. He urged everyone to think in ‘real time’ rather than jump ahead and to refrain from considering information that is not normally available at the time: for example, a laboratory report that takes 24 hours to obtain be assessed in the initial workup.
Give them the first two to live cues that were picked up in the first minute or two of the patient encounter either verbally, or written on a transparency. For example, age, sex race and reason for seeking medical help. Ask each group to discuss their first diagnostic hypotheses. Experts and novices will learn a great deal from each other at this stage and the discussions will be animated. The initial cues may number only one or two and hypothesis generation occurs very quickly even in the novices. Indeed, the only difference between the hypotheses of novices and those of experts is in the degree of refinement, not in number.
It is Saturday afternoon and you are the psychiatric emergency physician. A 25-year-old male arrives by ambulance and states that he is feeling suicidal. Groups talked for 4 minutes before the resident called for order to commence step three.
Call for order and ask people to offer their suggested diagnoses and write these up on a board or transparency.
The following hypotheses were suggested by the groups and the resident wrote them on a flip chart: depression, substance abuse, recent social stressors-crisis, adjustment disorder, organic problem, dysthymia, schizophrenia, bipolar affective disorder. The initial three or four bits of information generated eight hypotheses.
After all hypotheses have been listed instruct the audience to ask for the information they need to confirm or refute these hypotheses. Do not allow them to ‘jump the gun’ by asking for a test result, for example, that would not have been received within the time frame that is being re-lived. There will be a temptation to move too fast and the exercise is wasted if information is given too soon. Recall that the purpose is to help them go through a thinking process which requires time.
Teachers participating in this exercise will receive much diagnostic information about students’ thinking at this stage. Indeed, an interesting teaching session can be conducted by simply asking students to generate hypotheses without proceeding further. There is evidence to suggest that when a diagnosis is not considered initially it is unlikely to be reached over time, Hence it is worth spending time with students to discuss the hypotheses they generate before they proceed with an enquiry.
Directions to the group were to determine what questions they would like to ask, based on gender, age and probabilities, to support or exclude the listed diagnostic possibilities. A sample of question follow:
This step took 13 minutes.
After enough information has been gained to proceed, ask them to resume their discussion about the problem and reformulate their diagnostic hypotheses in light of the new information. Instruct them to discuss which pieces of information changed the working diagnosis and why. Call for order again and ask people what they now think.
After allowing the group to talk for a few minutes, the resident asked them if there was enough information to strike off any hypotheses or if new hypotheses should be added to the list. One more possibility was added, post-traumatic stress disorder (PTSD). One group's list of priorities was major affective disorder with psychosis, schizophrenia, personality disorder. Another group also placed affective disorder first followed by organic mood disorder.
This step took 25 minutes.
Alter the original lists of hypotheses on the board in light of the discussion, or allow one member from each group to alter their own lists. By the use of open-ended questions encourage a general discussion about the reasons a group has for preferring one diagnosis over another.
A general discussion ensued about reasons for these priorities. Then the list was altered so that it read: schizophrenia, personality disorder, PTSD, major affective disorder with psychosis, organic mood disorder.
Continue with another round of information and small-group discussion or else allow the whole group to interact. By giving information only when asked for and only in correct sequence, each person is challenged to think through the problem.
More information was sought, such as: form of speech? eye contact? affect? substance use? After 5 minutes the resident asked if there were only lab tests they would like. The group asked for thyroid stimulating hormone, T4, electrolytes and were given the results. They also asked for the results of the physical examination and were told that the pulse was 110 and the thyroid was enlarged. At this point some hypotheses were removed from the list.
When there is a lull in the search for information, ask the groups to reach consensus on their final diagnosis, given the information they have. Allow discussion within the groups.
On each group's list of hypothesis, star or underline the final diagnosis.
The group decided that the most likely diagnosis was affective disorder with psychosis, the actual working diagnosis of the patient.
If there is enough time, ask them to form small groups again to discuss treatment options, or conduct the discussion as a large group. Again ask for the reasons why one approach is preferred over another. Particularly ask the experts in the room for their reasoning so that the novices can learn from them.
By the time the end is in sight the audience will be so involved that they will not wish to leave. However, 5 minutes before time, call for order and summarize the session. Highlight the key points that have been raised and refer to the objective of the session.
We are now at the end of our time. You have all had the opportunity to use your clinical reasoning skills to generate several hypotheses which are shown on the board. Initially you thought it possible that this man could have any one of a number of diagnoses including depression, substance abuse, adjustment disorder with depressed mood, organic mood disorder or post-traumatic stress disorder. With further information the possible diagnosis shifted to include schizophrenia and personality disorder as well as depression with psychotic features. Finally the diagnosis of depression or mood disorder with psychosis was most strongly supported because of the history of consistently depressed mood over several months, along with disturbed sleep, poor appetite, weight loss, decreased energy and diminished interest in most activities. The initially abnormal thyroid test proved to be a red herring so organic mood disorder related to hyper- or hypo-thyroidism was excluded. Additionally absence of vivid dreams involving a traumatic event made a diagnosis of post-traumatic stress disorder unlikely. Although a diagnosis of schizophrenia could not be totally excluded, this seemed less likely given the findings.
In some respects, but only some, teaching is like acting and one should strive to leave them not laughing as you go, but feeling that they have learned something.
The more novice members of the group have learned from the more experienced and all your suggestions have been valid. It has been interesting for me to follow your reasoning and compare it with mine when I actually saw this man. You have given me a different perspective as you thought of things I had not, and I thank you for your participation.
Although case presentation should be a major learning experience for both novice and experienced physicians they are often conducted in a stultifying way that defies thought. We have presented a series of steps which, if followed, guarantee active participation from the audience and ensure that if experts are in the room their expertise is used. Physicians have been moulded to believe that teaching means telling and, as a consequence, adopt a remote listening stance during case presentations. Indeed the back row often use the time to catch up on much needed sleep! Changing the format requires courage. We urge you to try out these steps so that both you and your audience will learn from and enjoy the process.
BMC Infectious Diseases volume 24 , Article number: 908 ( 2024 ) Cite this article
Metrics details
Studying the characteristics of hospitalized Coronavirus Disease 2019 (COVID-19) patients is vital for understanding the disease and preparing for future outbreaks. The aim of this study was to analyze and describe the clinical profiles and factors associated with mortality among COVID-19 patients admitted to Jimma Medical Center COVID-19 Treatment Center (JMC CTC) in Ethiopia.
All confirmed COVID-19 patients admitted to JMC CTC between 17 April 2020 and 05 March 2022 were included in this study. Socio-demographic data, clinical information, and outcome variables were collected retrospectively from medical records and COVID-19 database at the hospital. Bivariable and multivariable analyses were performed to determine factors associated with COVID-19 severity and mortality. A P-value < 0.05 was considered statistically significant.
A total of 542 confirmed COVID-19 patients were admitted to JMC CTC, of which 322 (59.4%) were male. Their median age was 48 years (IQR 32–64). About 51% ( n = 277) of them had severe COVID-19 upon admission. Patients with hypertension [AOR: 2.8 (95% CI: 1.02–7.7, p = 0.046)], diabetes [AOR: 8.8 (95% CI: 1.2–17.3, p = 0.039)], and underlying respiratory diseases [AOR: 18.8 (95% CI: 2.06–71.51, p = 0.009)] were more likely to present with severe COVID-19 cases. Overall, 129 (23.8%) died in the hospital. Death rate was higher among patients admitted with severe disease [AHR = 5.5 (3.07–9.9) p < 0.001)] and those with comorbidities such as hypertension [AHR = 3.5 (2.28–5.41), p < 0.001], underlying respiratory disease [AHR = 3.4 (1.97–5.94), p < 0.001], cardiovascular disease (CVDs) [AHR = 2.8 (1.73–4.55), p < 0.001], and kidney diseases [AHR = 3.7 (2.3–5.96), p < 0.001].
About half of COVID-19 cases admitted to the hospital had severe disease upon admission. Comorbidities such as hypertension, diabetes, and respiratory diseases were linked to severe illness. COVID-19 admissions were associated with high inpatient mortality, particularly among those with severe disease and comorbidities.
Peer Review reports
More than four years after its declaration as a global pandemic, COVID-19 remains a dynamic public health concern, with the emergence of new variants influencing transmission patterns and epidemiological trends [ 1 , 2 ]. While global vaccination efforts have significantly reduced severe cases and mortality, disparities in vaccine access and uptake persist, especially in low- and middle-income countries [ 3 ]. By late 2023, there was a notable resurgence of cases in several regions, including Europe and North America, primarily due to the emergence of more transmissible variants [ 4 ]. In sub-Saharan Africa, challenges such as limited healthcare infrastructure and underreporting of cases continue to pose significant obstacles. Many African countries still experience lower testing rates compared to other regions, contributing to an underestimation of the true burden of COVID-19 [ 5 ]. The gap between documented cases and estimated seroprevalence rates suggests ongoing underreporting, underscoring the need for improved surveillance and reporting systems to better capture the pandemic’s full impact [ 6 , 7 ].
Vaccinations have significantly reduced COVID-19 transmission, severe illness, and mortality. However, disparities in vaccine distribution and acceptance, especially in low- and middle-income countries, hinder global herd immunity [ 8 , 9 ]. Africa faces particular challenges with low vaccination rates due to supply shortages, logistical issues, vaccine hesitancy, and limited healthcare infrastructure [ 10 , 11 ]. The emergence of new SARS-CoV-2 variants complicates efforts to combat the pandemic, as these variants may affect transmissibility, disease severity, and vaccine efficacy [ 12 , 13 , 14 ]. Some variants, like Delta, have shown increased transmissibility and can lead to breakthrough infections among vaccinated individuals, partly due to mutations in the spike protein [ 15 ].
Various risk factors are associated with severe illness and mortality from COVID-19. These include advanced age, underlying health conditions such as hypertension, diabetes, cardiovascular disease, chronic respiratory disease, obesity, and states of immunocompromise [ 16 , 17 ]. Furthermore, demographic factors such as male gender [ 18 ], socioeconomic status, and access to healthcare resources have also been recognized as playing roles in determining the severity and fatality of the disease [ 19 ].
Ethiopia faced significant challenges during the COVID-19 pandemic, including limited healthcare infrastructure and economic constraints [ 20 ]. The government quickly implemented measures such as lockdowns, travel restrictions, and hygiene promotion [ 21 ]. Despite these efforts, the country’s response was hampered by limited testing and medical resources [ 22 ]. The Ethiopian Public Health Institute and the Ministry of Health led initiatives for surveillance, contact tracing, and public awareness, with international support, including vaccines through COVAX [ 23 ]. The response aimed to balance public health measures with economic and social impacts, highlighting the challenges of managing a pandemic in a developing country [ 24 , 25 ].
Furthermore, the lack of comprehensive scientific data on COVID-19 outcomes has hindered evidence-based decision-making and the implementation of targeted public health interventions in Ethiopia. Strengthening research infrastructure and fostering international collaborations will not only enhance the current response but also pave the way for more effective future preparedness efforts, ensuring the protection of public health in Ethiopia and beyond [ 26 ]. Therefore, this study aimed to assess the clinical profile and outcomes of hospitalized COVID-19 patients at Jimma Medical Center (JMC) in southwest Ethiopia.
We reviewed medical records of all patients admitted with COVID-19 to the Jimma Medical Center (JMC) COVID-19 Treatment Center (CTC) between 17 April 2020 and 05 March 2022. The center, established on 13 March 2020, had a capacity of 23 beds and was equipped with mechanical ventilators, oxygen concentrators, and patient monitors. Integrated with JMC, it was the only COVID-19 intensive care facility in southwest Ethiopia. The center consisted of management and operation sections, with the management team including a scientific advisory council and the operation section divided into six sub-teams: [ 1 ] Isolation & Case Management, [ 2 ] Surveillance, [ 3 ] Risk Communication & Community Engagement (RCCE), [ 4 ] Water, Sanitation, & Hygiene (WASH) and Infection Prevention Control (IPC), [ 5 ] Research, Innovation, and Diagnostics, and [ 6 ] Administration, Data Management, and Finance [ 27 ].
Patients whose medical records confirmed the presence of the virus through the identification of viral ribonucleic acid (RNA) in nasopharyngeal swab samples using reverse transcription polymerase chain reaction (RT-PCR) either upon admission or during hospitalization, regardless of whether they exhibited symptoms, were included in the study.
Patient sociodemographic and clinical characteristics were collected from medical records and the COVID-19 database at JMC-CTC. The collected data included various aspects such as demographics, clinical manifestations, comorbidities, disease severity upon admission, time/date of admission, length of stay, and discharge outcome.
Operational definitions .
COVID-19 specific symptoms (classic): Fever, cough, shortness of breath, loss of smell or taste [ 28 ].
Extended symptoms: Sore throat, runny nose, arthralgia, fatigue, and headache [ 28 ].
Mild illness: A person has any of the COVID-19 symptoms except for shortness of breath and difficulty breathing [ 29 ].
Moderate illness: A person may have lower respiratory tract illness with clinical or radiographic evidence. However, their blood oxygen levels remain at 94% or higher [ 29 ].
Critical COVID: A COVID-19 case requiring mechanical ventilation or hemodynamic support. This includes patients with acute respiratory distress syndrome, multi-organ dysfunction or failure, and shock [ 29 ].
Non-severe COVID-19: A person with mild to moderate symptoms that do not require hospitalization. This includes individuals with mild symptoms (any COVID-19 symptoms except shortness of breath and difficulty breathing) and moderate symptoms (lower respiratory tract illness with clinical or radiographic evidence but blood oxygen levels at 94% or higher) [ 29 , 30 ].
Severe illness: A person has blood oxygen levels that are less than 94%, a high breathing rate (≥ 30 breaths/min), and signs of severe lung disease (lung infiltrates > 50%) [ 29 ].
Category 1: One or more classic symptom without extended symptoms.
Category 2: One or more classic symptom with extended symptom.
Category 3: One or more extended symptom without classic symptoms.
The original data collected in Microsoft Excel was reviewed for completeness and consistency before being exported to SPSS ® version 26 (IBM ® , New York, USA) for analysis. Normality tests were conducted using visual inspections of histograms and Q-Q plots, as well as the Kolmogorov-Smirnov and Shapiro-Wilk tests. For the bivariate analysis, independent variables with a p-value less than 0.25 were selected as candidates for the multivariable logistic regression analysis. A binary logistic regression model was then used to explore risk factors for the severity of COVID-19 infection. Additionally, a Cox regression analysis was employed to identify predictors of mortality in COVID-19 patients. The equality of survival distributions for different severity levels was tested using Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon), and Tarone-Ware tests. A p-value of less than 0.05 was used as the threshold for statistical significance.
From April 2020 to March 2022, a total of 542 COVID-19 patients were admitted to JMC CTC, of which 322 (59.4%) were male. The median age was 48 years (IQR 32–64), with a range of 3 to 102 years. More than half (50.8%) of the cases were younger than 50 years of age. The most frequently reported symptoms were dyspnea (60%) and cough (57.6%). Among those with severe disease, 57.4% and 54% of patients exhibited cough and dyspnea, respectively. Comorbidities were reported in 21.8% of the admitted patients. Among those who died, the majority had comorbidities (80.6%), with hypertension being the most common at 44.2% (Table 1 ).
Until November 2020, most admissions were due to non-severe cases. Subsequently, the non-severe admission declined, while admissions due to severe cases gradually increased reaching peak of 49 in April 2021. From June to August 2021, only two cases, both of which were severe, were admitted to the center. The number of admissions, primarily due to severe cases, increased after September 2021 (Fig. 1 ).
Pattern of admission and clinical severity of COVID-19 cases admitted to JMC CTC since April 2020 to March 2022
Univariate binary logistic regression analyses were conducted to assess the individual factors associated with severe COVID-19 cases. Subsequently, candidate variables for the final multivariate analysis were selected based on their statistical significance in the univariate analyses. Accordingly, age, admission symptoms, and comorbidities such as hypertension, diabetes, respiratory disease, cardiovascular diseases (CVDs), and kidney diseases, were selected for inclusion in the multivariate logistic regression analysis.
The analysis indicated that with each additional year of age, the odds of experiencing a more severe form of the disease increased by 4% (AOR: 1.04, 95% CI: 1.03–1.05, p < 0.001).
Additionally, individual comorbidities were independently analyzed after adjusting for the presence and absence of comorbidities. Hypertensive patients showed a nearly threefold increased odds of more severe disease compared to non-hypertensive patients [AOR: 2.8 (95% CI: 1.02–7.7, p = 0.046)]. Diabetic patients had approximately nine times higher odds of experiencing severe disease compared to non-diabetic patients [AOR: 8.8 (95% CI: 1.2–17.3, p = 0.039)]. Patients with respiratory diseases exhibited the highest odds of severe disease, with an 18.8-fold increase compared to those without respiratory conditions [AOR: 18.8 (95% CI: 2.06–71.51, p = 0.009)] (Table 2 ).
A total of 129 (23.8%) patients died during their hospitalization. The median length of hospital stay was 9.5 days (IQR: 6–15), with duration ranging from one to 40 days. Most of the deceased patients ( n = 81, 62.8%) died within the first 7 days of admission. Additionally, 120 (22.1%) patients were transferred to home-based care or nearby facilities for further treatment and follow-up.
During the first five months, there were no admissions of severe cases and death at the center. However, as time progressed, there was a gradual increase in severe cases, culminating in the highest number of deaths during three peak periods: April 2021 ( n = 18), October 2021 ( n = 19), and January 2022 ( n = 16) (Fig. 2 ).
Trends in Mortality and Severe Case Admissions among COVID-19 Patients at JMC CTC from April 2020 to March 2022
The clinical severity status at admission was significantly associated with survival outcomes (p-value < 0.001) (Supplementary Table 1 ). Patients who were severely ill at the time of admission had poorer survival rates and a shorter time to death (Fig. 3 ).
Kaplan–Meier curves displaying the estimated survival time of patients with COVID-19 stratified by the severity status on admission and length of hospital stay at JMC CTC from April 2020 to March 2022
Univariate Cox regression analyses assessed individual factors associated with the hazard of death among COVID-19 patients. Variables with fewer than 5 occurrences were excluded due to insufficient sample size for reliable estimates. Factors significant in univariate analyses, including age, clinical severity, and comorbidities (hypertension, diabetes, respiratory disease, cardiovascular disease, and kidney disease), were selected for the multivariate Cox regression analysis.
Severe disease was associated with a 5.5-fold increased hazard of death compared to non-severe cases (AHR: 5.5; 95% CI: 3.07–9.9, p < 0.001). Additionally, individual comorbidities were independently analyzed after adjusting for the presence and absence of comorbidities. Hypertension, respiratory disease, cardiovascular disease, and kidney disease were linked to increased COVID-19 mortality risk, with the following AHR and 95% CI: hypertension [3.5(2.28–5.41), p < 0.001], respiratory disease [3.4(1.97–5.94), p < 0.001], cardiovascular disease [2.8(1.73–4.55), p < 0.001], and kidney disease [3.7(2.3–5.96), p < 0.001] (Table 3 ).
A total of 542 patients were admitted to JMC CTC between April 2020 and March 2022. Cough and dyspnea were the most frequently reported symptoms. Approximately 51% of the patients were classified as having severe COVID-19 at the time of hospitalization. The mortality rate was 23.8%, with a significant majority of the deceased patients (80.6%) having comorbidities, particularly hypertension. Conditions such as hypertension, respiratory disease, and cardiovascular disease were strongly associated with severe outcomes and increased risk of mortality.
During the first few months of the COVID-19 pandemic, Ethiopia did not experience a major outbreak with very low mortality rate [ 31 ]. However, by August 2020, the country began active case finding through a large-scale community-based activity and testing (CoMBaT) strategy [ 32 ]. This resulted in an increase in admissions for both severe and non-severe cases. Our study also revealed that there were no admissions due to severe COVID-19 or COVID-19 related deaths at JMC until August 2020. The low number of cases during that period may have been a result of limited testing and low disease outbreak. However, starting in September 2020, non-severe admissions decreased as Ethiopia revised its strategy of blanket admission of all confirmed COVID-19 cases to only severe cases and high-risk patients.
Since February 2021, there has been a notable increase in severe cases. The highest number of overall admissions occurred in April 2021, with a majority being severe cases ( n = 49) out of a total of 69 admissions. Following this peak, there was a substantial decline over the next four months: May ( n = 29), June ( n = 0), July ( n = 0), and August ( n = 2). This pattern can be attributed to the second wave, which began in late January 2021 and persisted until the end of May 2021 [ 33 ]. During this period, the Alpha variant, known for its increased transmissibility [ 34 ] and higher hospitalization rates compared to earlier strains [ 35 ], predominated COVID-19 cases in Ethiopia [ 33 ]. These findings align with a study conducted from publicly available data on COVID-19 admissions in Ethiopia [ 36 ]. Our study also revealed that admissions due to severe COVID-19 and deaths peaked in October 2021 and January 2022. These peaks corresponded with the third and the fourth waves of COVID-19 outbreak in Ethiopia, which were dominated by the Delta and Omicron variants, respectively [ 37 ].
Ethiopia began COVID-19 vaccination in March 2021 [ 38 ]. Although the number of admissions and deaths at the hospital significantly decreased between May and August 2021, it is difficult to attribute this to the vaccination because only less than 5% of the population was vaccinated during this time [ 39 ].
Clinical parameters, including symptom category at admission and pre-existing comorbidities, were found to be associated with COVID-19 severity. Patients with one or more classic COVID-19 symptoms were more likely to present with severe illness compared to asymptomatic individuals by 15.9 folds. The odds increased to 17.2 among those with classic symptoms plus extended symptoms. This finding aligns with a retrospective analysis from China, which reported that the likelihood of developing severe illness increased with an increasing number of presenting symptoms at hospital admission [ 40 ]. This finding is also consistent with a global systematic review and meta-analysis that involved data from 14 countries [ 41 ]. Previous studies have suggested that an aberrant host immune response and cytokine storm may significantly contribute to the severity of COVID-19 [ 42 ].
In this study, age was associated with the severity of COVID-19. For each additional year of age, the likelihood of experiencing a more severe form of the disease increased by 4%, which aligns with findings from previous studies [ 43 , 44 , 45 ]. Additionally, patients with comorbidities such as hypertension, diabetes, and respiratory diseases were more likely to experience severe COVID-19 illness. Several systematic reviews have found similar patterns in both developing and developed countries, indicating that the relationship between comorbidities and the severity of COVID-19 is consistent across different socioeconomic contexts [ 41 , 46 , 47 ].
The median length of hospital stay was 9.5 days (IQR 6–15), with range of one to 40 days. This is consistent with findings from other studies conducted in Ethiopia [ 48 , 49 ]. However, this finding is lower than studies from China [ 50 ], US [ 51 ], and Sweden [ 52 ]. The shorter median hospital stay observed in our study compared to those from China, the US, and Sweden may reflect variations in treatment protocols, healthcare resources,, and patient demographics across these regions.
Our study also showed that clinical severity and pre-existing comorbidities were significantly associated with the risk of death. Severe disease was associated with a 5.5-fold increased hazard of death compared to non-severe cases. This finding is consistent with systematic reviews and meta-analyses from Sub-Saharan countries [ 53 ] as well as Asia, North America, Europe, and South America [ 54 ]. Additionally, comorbidities including, hypertension (AHR: 3.5), respiratory disease (AHR: 3.4), cardiovascular disease (AHR: 2.8), and kidney disease (AHR: 3.7) were linked to increased COVID-19 mortality risk. Our findings are consistent with different systematic review meta-analysis studies [ 53 , 54 , 55 , 56 , 57 , 58 ]. This is because chronic conditions are often associated with a subclinical inflammation, weakened innate immune responses, and increased expression of ACE-2 receptor, which facilitates the entry of SARS-CoV-2 into the host cells and is associated with higher COVID-19 mortality [ 45 ].
This study covered nearly two years of COVID-19 pandemic, focusing on COVID-19 related hospitalizations to a tertiary teaching hospital in Ethiopia, and provides valuable insights into COVID-19 in African contexts. While the study offers original findings, it is limited by its retrospective design. Retrieving data from medical records was found to be a challenge due to incomplete documentations and lost records. Moreover, the lack of routinely recorded laboratory and imaging results, as well as case management details, prevented their inclusion in this study.
This study found that patients hospitalized with severe symptoms and comorbidities—such as hypertension, respiratory disease, cardiovascular disease, and kidney disease—faced a significantly higher risk of in-hospital mortality. The study also identified distinct patterns in admissions and mortality that corresponded with the pandemic waves and variant prevalence in Ethiopia. Although vaccination efforts began in March 2021, their impact on admissions and mortality was minimal during the study period due to low vaccination coverage. Overall, this research enhances our understanding of COVID-19 outcomes in African contexts and highlights the importance of ongoing monitoring and management, especially with the emergence of new variants and evolving data.
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We extend our heartfelt gratitude to the Jimma Emergency Operation Center, Jimma Medical Center, and the dedicated study teams for their invaluable support during the intervention and data collection process.
This research received no specific grant from any funding agency in the public, commercial, or non-profit sectors.
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Department of Public Health, Jimma University, P.O.Box 378, Jimma, Oromia, Ethiopia
Eyob Girma Abera
Clinical Trial Unit, Jimma University, Oromia, Ethiopia
Eyob Girma Abera, Daniel Yilma & Esayas Kebede Gudina
Department of Internal Medicine, Jimma University, Jimma, Oromia, Ethiopia
Kedir Negesso Tukeni, Daniel Yilma & Esayas Kebede Gudina
Center Hospitalier Saint-Joseph Saint-Luc, Lyon, France
Kedir Negesso Tukeni
Department of Health Policy and Management, Jimma University, Jimma, Oromia, Ethiopia
Temesgen Kabeta Chala
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EGA and EKG conceptualized and designed the study. EGA analyzed the data and wrote the original draft. TKC and KNT involved for data curation. EKG and DY provided supervision for the overall activities. All authors accepted responsibility for all aspects of the research, including writing, reviewing, and editing, and approved the final version of the manuscript.
Correspondence to Eyob Girma Abera .
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Ethical approval for the study was obtained from the Institutional Review Board (IRB) of Jimma University, Institute of Health (Reference number: RPGD/978/2020). The IRB of Jimma University, Institute of Health, also granted a waiver for the requirement of informed consent to participate, as the study involved a retrospective review of anonymized medical records. All data were handled with strict confidentiality to ensure participant anonymity.
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Abera, E.G., Tukeni, K.N., Chala, T.K. et al. Clinical profiles and mortality predictors of hospitalized patients with COVID-19 in Ethiopia. BMC Infect Dis 24 , 908 (2024). https://doi.org/10.1186/s12879-024-09836-6
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DOI : https://doi.org/10.1186/s12879-024-09836-6
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Presenting patient cases is a key part of everyday clinical practice. A well delivered presentation has the potential to facilitate patient care and improve efficiency on ward rounds, as well as a means of teaching and assessing clinical competence. 1. The purpose of a case presentation is to communicate your diagnostic reasoning to the ...
Summarize the major points of the case. Provide a limited number (e.g. 3) of takeaway points for the audience. Tailor summary and takeaway points to your audience. Critical Thinking Skills. Successful patient case presentations: Integrate disease and drug knowledge, clinical evidence, and patient factors.
To save you time and effort, I have curated a list of 5 versatile case study presentation templates, each designed for specific needs and audiences. Here are some best case study presentation examples that showcase effective strategies for engaging your audience and conveying complex information clearly. 1. Lab report case study template.
How to Present a Patient. Opener. You should begin every oral presentation with a brief one-liner that contains the patient's name, age, relevant past medical history, and chief complaint. Remember that the chief complaint is why the patient sought medical care in his or her own words.
7 Ingredients for a Patient Case Presentation Template. 1. The One-Liner. The one-liner is a succinct sentence that primes your listeners to the patient. A typical format is: " [Patient name] is a [age] year-old [gender] with past medical history of [X] presenting with [Y]. 2.
Writing up. Write up the case emphasising the interesting points of the presentation, investigations leading to diagnosis, and management of the disease/pathology. Get input on the case from all members of the team, highlighting their involvement. Also include the prognosis of the patient, if known, as the reader will want to know the outcome.
This part describes the existing theories and research findings on the key issue in the patient's condition. The review should narrow down to the source of confusion or the main challenge in the case. Finally, the case report should be connected to the existing literature, mentioning the message that the case conveys.
In this video we discuss the SNAPPS method of case presentation. It's a bit more advanced than the Signpost Method found athttps://youtu.be/Mew2wzpuhTs . SN...
xt should not be more than 300 words.In order to give an oral presentation, you need to compress the patient's medical illness and the physical findings into a concise r. itation of the most essential facts. You need to give all of the relevant information without extraneous details so that the person reading it should be able to construct ...
Abstract. Clinical case presentation is part of daily routine for doctors to communicate with each other to facilitate learning, and ultimately patient management. Hence, the art of good clinical case presentation is a skill that needs to be mastered. Case presentations are a part of most undergraduate and postgraduate training programs aimed ...
Clinical presenting is the language that doctors use to communicate with each other every day of their working lives. Effective communication between doctors is crucial, considering the collaborative nature of medicine. As a medical student and later as a doctor you will be expected to present cases to peers and senior colleagues.
The aim of this study was to get junior doctors to evaluate an online presentation as part of the process of developing a beginner's guide to writing a clinical case report. Materials and methods. In response to our previous studies an online presentation concerning how to write a clinical case report was provided for junior doctors.
4. Don't forget the physical examination: most of the times it will indicate the diagnosis; therefore, vital signs and a detailed physical examination are key components of your clinical case. 5. Provide high-quality imaging (figures and/or videos) to support the information within the text. 6.
5. Review the outline with your mentor or interested colleagues, and listen to their decisions. Use the Preparing the Clinical Vignette Presentation Checklist to assist you in preparing the topic outline. If you are scheduled to make a presentation of a clinical vignette, reading this article will improve your performance.
The preparation for the presentation will depend on what information is to be included. Generally, oral case presentations are brief and should be limited to 5-10 minutes. This may be extended if the case is being presented as part of an assessment compared with routine everyday working (see 'Case-based discussion').
This video from the University of Calgary teaches you the Signpost Method of case presentation. This is a simple way for junior clinical learners to present...
A clinical case report or case study is a means of disseminating new knowledge gained from clinical practice. Clinical case reports are the first-line evidence in medical literature as they present original observations. This article provides detailed guidance on how to identify, write, and publish a case report.
Submit Your Case: The Sky Is the Limit. As a last message, to all of the young authors who are trying to get their clinical cases published, remember that the "sky is the limit"—be creative, find a good mentor, and write up an interesting case. Once your manuscript is accepted, it is just the beginning of your academic career.
Clinical Case Studies (CCS), peer-reviewed & published bi-monthly electronic only, is the only journal devoted entirely to innovative psychotherapy case studies & presents cases involving individual, couples, & family therapy.The easy-to-follow case presentation format allows you to learn how interesting & challenging cases were assessed & conceptualized, & how treatment followed such ...
It is best to simply tell the story and let the outcome speak for itself. With these points in mind, let's begin the process of writing the case study: Title page: Title: The title page will contain the full title of the article. Remember that many people may find our article by searching on the internet.
Two BMJ Case Reports journal editors take you through the process #### This article contains... During medical school, students often come across patients with a unique presentation, an unfamiliar response to treatment, or even an obscure disease. Writing a case report is an excellent way of documenting these findings for the wider medical community—sharing new knowledge that will lead to ...
Clinical Case Study Presentation Template. Number of slides: 10. Signup Free to download. A clinical case study is a report where medical practitioners share a patient's case. Generally, clinical case studies are valuable tools for medical research as they provide detailed information on the development of a disease or illness in particular ...
No grade given. Case study patient approved by clinical supervisor. Intern coordinated presentation date/time with SRD and clinical RDNs. CCS was presented to RDNs at NT facility at least 2 weeks prior to CSULB class presentation. It is also recommended to go over CCS presentation with SRD prior to presentation at facility.
An effective verbal presentation with an impressive slide deck which is presented to a high standard is not easily obtained without experience, practice and consideration. As healthcare staff that work in healthcare simulation, presentation skills are often expected as part of the role as a clinical educator.However, there is often no formal education provided to staff and skill acquisition ...
Latest data from Poseida's lead investigational allogeneic CAR-T program, which is based on the Company's unique stem cell memory T cell (T SCM) platform. Company to host conference call on Saturday, September 28, 2024, at 1 PM ET / 10 AM PT to review the P-BCMA-ALLO1 Phase 1 IMS oral presentation data . Poseida initiates P-BCMA-ALLO1 Phase 1b clinical trial in patients with multiple myeloma ...
The one-internship option is the most flexible way to complete your 60-credit master's degree program in Clinical Mental Health Counseling with a specialization in Trauma Studies or Holistic Studies. If you choose to do one internship, over 2 semesters, you'll engage in 700 hours of supervised internship/field experience in a clinical setting.
In this study, we explore the practical implications of a deliberate behavioral management program that incorporates cooperative training. We present case studies demonstrating how this approach enhances the execution of timely medical care and comprehensive health monitoring while minimizing the need for stress-inducing techniques like sedation.
Medtronic plc, the global leader in medical technology, announced it will present new data on its MiniMed™ 780G system at the upcoming European Association for the Study of Diabetes (EASD) 60th Annual Meeting in Madrid on September 9-13.The new clinical evidence on the MiniMed™ 780G system will include areas where the company intends to work with global regulators towards expanding access ...
The primary objective is to analyze the clinical reasoning that was used rather than the knowledge required, although the acquisition of such knowledge is an added benefit of the session. A "well organized case presentation or clinicopathological conference incorporates the logic of the workup implicitly and thus makes the diagnostic process ...
Studying the characteristics of hospitalized Coronavirus Disease 2019 (COVID-19) patients is vital for understanding the disease and preparing for future outbreaks. The aim of this study was to analyze and describe the clinical profiles and factors associated with mortality among COVID-19 patients admitted to Jimma Medical Center COVID-19 Treatment Center (JMC CTC) in Ethiopia.