However, 4NQO is the preferred carcinogen apart from DMBA in the development of experimental oral carcinogenesis. 4NQO is a water soluble carcinogen, which induces tumors predominantly in the oral cavity. It produces all the stages of oral carcinogenesis and several lines of evidences suggest that similar histological as well as molecular ...
Understanding Carcinogenesis for Fighting Oral Cancer
A number of chemical carcinogens including coal tar, 20-methylcholanthrene, DMBA, and 4-NQO have been used in experimental oral carcinogenesis. However, 4-NQO is the preferred carcinogen apart from DMBA in the development of experimental oral carcinogenesis. 4-NQO is a water-soluble carcinogen, which induces tumors predominantly in the oral cavity.
4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A
4NQO-induced carcinogenesis is a classic animal model used in 1960 as an in vivo tool to study oral cancer development [36], [37]. The present systematic review confirmed the efficacy of 4NQO for experimental oral carcinogenesis through topical and systemic administration (Fig. 4). Considerable heterogeneity was observed among systemic ...
4NQO induced carcinogenesis. 4NQO exerts potent intracellular oxidative stress and the metabolic product of it binds to DNA predominantly at guanine residues. These insults appear similar to damage imposed by other carcinogens present in tobacco, which is a major risk factor for oral cancer.
A scientometric study of chemical carcinogen-induced experimental oral
Results. There were 506 and 349 papers on 4NQO- and DMBA-induced experimental oral carcinogenesis with 10,152 and 6306 citations, respectively. The common distinctive keywords such as rat, tongue neoplasms, drinking water, tumor microenvironment, and cyclooxygenase (COX)-2 were identified in the papers on 4NQO; and the common keywords such as hamster, cheek pouch, lipid peroxidation ...
Current mouse models of oral squamous cell carcinoma: Genetic and
The dynamics of gene expression alterations in the 4NQO mouse model of human oral carcinogenesis that lead to the development of preneoplastic histological changes such as hyperplasia and dysplasia followed ... 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol, 42 (2006), pp. 655-667. View PDF View article View in ...
Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced
4-Nitroquinoline 1-oxide-induced experimental oral carcinogenesis. Several animal models for oral SCC were previously generated, including those for hamsters, rats, and mice.The 4NQO-induced tongue carcinogenesis model is anatomically more similar to human SCC, more convenient, and likely more reproducible, as the carcinogen is administered in ...
A scientometric study of chemical carcinogen-induced experimental oral
Background/purpose: 4-Nitroquinoline 1-oxide (4NQO)-induced tongue carcinoma and 7,12-dimethlybenz(a)anthracene (DMBA)-induced cheek pouch carcinoma are the most common and classical chemical carcinogen-induced animal models of oral carcinogenesis. The purpose of this study was to provide the research trends and characteristics of 4NQO- and DMBA-induced experimental oral carcinogenesis.
Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced
Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced experimental oral carcinogenesis model using gas chromatography-mass spectrometry PeerJ. 2021 Jan 4:9:e10619. doi: 10.7717 ... The results found 16 metabolites associated with 4NQO-induced rat tongue carcinogenesis. Dysregulated arachidonic acid, fatty acid, and glycine metabolism ...
4NQO reliably produced preneoplastic and neoplastic tongue mucosa lesions, which morphologically and histologically mimic human oral carcinogenesis, which should be appropriate to study molecular mechanism of neoplastics transformation and to assess new treatment modalities of premalignant and malignant lesions of the human oral cavity.
4NQO Carcinogenesis: A Model of Oral Squamous Cell Carcinoma
The experimental oral carcinogenesis induced by the chemical 4-nitroquinoline 1-oxide (4NQO) is one of the most frequent in the study of squamous cell carcinoma of the oral cavity (CCEC).
Oral Carcinogenesis and Oral Cancer Chemoprevention: A Review
The most widely used animal models for oral carcinogenesis are the hamster cheek pouch model [62, 65] and the 4-nitroquinoline 1-oxide- (4-NQO-) induced oral (tongue) carcinogenesis model [8, 61, 66, 67]. DMBA is one of the widely used carcinogens in experimental oral carcinogenesis.
(PDF) Protective role of Maha Vallathy Leghiyam on 4 ...
4-nitroquinoline-1-oxide-induced experimental oral . carcinogenesis. G. Priyanka 1,2, Kayalvizhi Elumalai 1 * ... (4NQO) induced rat oral carcinogenesis. Materials and methods: The male wistar ...
4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A
The papers on both 4NQO- and DMBA-induced experimental oral carcinogenesis were published since 1962. All the eligible papers were retrieved on 12 May 2023 from the Scopus database. There were 506 and 349 papers on 4NQO- and DMBA-induced experimental oral carcinogenesis with 10,152 and 6306 citations, respectively. The common distinctive ...
PDF 4-Nitroquinoline-1-oxide induced experimental oral carcinogenesis
REVIEW 4-Nitroquinoline-1-oxide induced experimental oral carcinogenesis Deepak Kanojia, Milind M. Vaidya * Biochemistry and Cell Biology, Tata Memorial Hospital, Cancer Research Institute,
Use of 4NQO animal models for the development of biomarkers. 4NQO mediated experimental carcinogenesis is similar to human oral carcinogenesis. Therefore, it has been widely used for the possible development of biomarkers for human oral cancer. Proteins of signal transduction pathways like apoptosis, cell cycle, cell-cell signaling and other ...
A scientometric study of chemical carcinogen-induced experimental oral
Materials and methods. As per the methodology described previously, 9, 10 all the papers on 4NQO- and DMBA-induced experimental oral carcinogenesis were retrieved on 12 May 2023 from the Scopus database. According to the search strategy described in Supplementary Table S1, we used medical subject term "4NQO" or "DMBA" and the respective synonyms in the title/abstract to retrieve the ...
coal tar, 20 methyl cholanthrene (20MC), 9,10-dimethyl-1,2-benzanthracene (DMBA) and 4-. nitroquinoline-1-oxide (4NQO) have been used in experimental oral carcinogenesis. However, 4NQO is the ...
PD-1 blockade prevents the progression of oral carcinogenesis
Meanwhile, chemically induced mouse models of oral carcinogenesis were constructed with 4-nitroquinolone-N-oxide induction. ... and an increased ratio of stem-like exhausted T cells and partially exhausted T cells were detected in the experimental groups. Besides, the expression of immune checkpoint markers (PDCD1, CTLA4 and HAVCR2) was ...
However, 4NQO is the preferred carcinogen apart from DMBA in the development of experimental oral carcinogenesis. 4NQO is a water soluble carcinogen, which induces tumors predominantly in the oral cavity. It produces all the stages of oral carcinogenesis and several lines of evidences suggest that similar histological as well as molecular ...
Prevention of carcinogen-induced oral cancers by polymeric ...
Experimental design for studying the effect of pre and concurrent treatment of different doses of black tea-derived PBPs extract on DMBA induced oral carcinogenesis in the hamster model. 6-8 ...
Myrtenal averts apoptotic evasion of cancer cells in 7,12-dimethylbenz
Apoptotic avoidance is one of the foremost characteristic features of tumour cells. Apoptotic induction in cancer cells could thus help to identify new anticancer agents from the natural products. The present study has taken an effort to investigate the apoptotic efficacy of myrtenal, a monoterpene, in 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinoma in male golden Syrian hamsters.
In Vivo Chemosuppressive Effects of Kolaviron on 7,12
Mammary carcinogenesis was induced using 80 mg/kg of 7,12-dimethylbenzanthracene (DMBA) administered by oral gavage. One hundred-fifty days post-DMBA induction, estrogen receptor-α (ER-α) levels were determined in the experimental rats before treatment with KV commenced.
PD-1 blockade prevents the development and progression of carcinogen
The preclinical data obtained with this experimental model or oral carcinogenesis provide knowledge that will help us to design effective trials for prevention treatment of patients considered at high risk of developing OSCCs. ... Vaidya MM. 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol. 2006; 42:655-67 ...
JPM
The primary aim of this study was to evaluate the activation of the PERP and Akt oncogenes in the induction of skin cancer in FVB/N mice by a stepwise chemical process. Forty four-week-old female FVB/N mice were randomly divided into a control group (n = 8) and two experimental groups (group A: n = 16, group B: n = 16). In the study, the groups were subjected to a two-stage carcinogenesis ...
In Vivo Chemosuppressive Effects of Kolaviron on 7,12
Mammary carcinogenesis was induced using 80 mg/kg of 7,12-dimethylbenzanthracene (DMBA) administered by oral gavage. One hundred-fifty days post-DMBA induction, estrogen receptor-α (ER-α) levels were determined in the experimental rats before treatment with KV commenced.
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However, 4NQO is the preferred carcinogen apart from DMBA in the development of experimental oral carcinogenesis. 4NQO is a water soluble carcinogen, which induces tumors predominantly in the oral cavity. It produces all the stages of oral carcinogenesis and several lines of evidences suggest that similar histological as well as molecular ...
A number of chemical carcinogens including coal tar, 20-methylcholanthrene, DMBA, and 4-NQO have been used in experimental oral carcinogenesis. However, 4-NQO is the preferred carcinogen apart from DMBA in the development of experimental oral carcinogenesis. 4-NQO is a water-soluble carcinogen, which induces tumors predominantly in the oral cavity.
4NQO-induced carcinogenesis is a classic animal model used in 1960 as an in vivo tool to study oral cancer development [36], [37]. The present systematic review confirmed the efficacy of 4NQO for experimental oral carcinogenesis through topical and systemic administration (Fig. 4). Considerable heterogeneity was observed among systemic ...
4NQO induced carcinogenesis. 4NQO exerts potent intracellular oxidative stress and the metabolic product of it binds to DNA predominantly at guanine residues. These insults appear similar to damage imposed by other carcinogens present in tobacco, which is a major risk factor for oral cancer.
Results. There were 506 and 349 papers on 4NQO- and DMBA-induced experimental oral carcinogenesis with 10,152 and 6306 citations, respectively. The common distinctive keywords such as rat, tongue neoplasms, drinking water, tumor microenvironment, and cyclooxygenase (COX)-2 were identified in the papers on 4NQO; and the common keywords such as hamster, cheek pouch, lipid peroxidation ...
The dynamics of gene expression alterations in the 4NQO mouse model of human oral carcinogenesis that lead to the development of preneoplastic histological changes such as hyperplasia and dysplasia followed ... 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol, 42 (2006), pp. 655-667. View PDF View article View in ...
4-Nitroquinoline 1-oxide-induced experimental oral carcinogenesis. Several animal models for oral SCC were previously generated, including those for hamsters, rats, and mice.The 4NQO-induced tongue carcinogenesis model is anatomically more similar to human SCC, more convenient, and likely more reproducible, as the carcinogen is administered in ...
Background/purpose: 4-Nitroquinoline 1-oxide (4NQO)-induced tongue carcinoma and 7,12-dimethlybenz(a)anthracene (DMBA)-induced cheek pouch carcinoma are the most common and classical chemical carcinogen-induced animal models of oral carcinogenesis. The purpose of this study was to provide the research trends and characteristics of 4NQO- and DMBA-induced experimental oral carcinogenesis.
Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced experimental oral carcinogenesis model using gas chromatography-mass spectrometry PeerJ. 2021 Jan 4:9:e10619. doi: 10.7717 ... The results found 16 metabolites associated with 4NQO-induced rat tongue carcinogenesis. Dysregulated arachidonic acid, fatty acid, and glycine metabolism ...
4NQO reliably produced preneoplastic and neoplastic tongue mucosa lesions, which morphologically and histologically mimic human oral carcinogenesis, which should be appropriate to study molecular mechanism of neoplastics transformation and to assess new treatment modalities of premalignant and malignant lesions of the human oral cavity.
The experimental oral carcinogenesis induced by the chemical 4-nitroquinoline 1-oxide (4NQO) is one of the most frequent in the study of squamous cell carcinoma of the oral cavity (CCEC).
The most widely used animal models for oral carcinogenesis are the hamster cheek pouch model [62, 65] and the 4-nitroquinoline 1-oxide- (4-NQO-) induced oral (tongue) carcinogenesis model [8, 61, 66, 67]. DMBA is one of the widely used carcinogens in experimental oral carcinogenesis.
4-nitroquinoline-1-oxide-induced experimental oral . carcinogenesis. G. Priyanka 1,2, Kayalvizhi Elumalai 1 * ... (4NQO) induced rat oral carcinogenesis. Materials and methods: The male wistar ...
The papers on both 4NQO- and DMBA-induced experimental oral carcinogenesis were published since 1962. All the eligible papers were retrieved on 12 May 2023 from the Scopus database. There were 506 and 349 papers on 4NQO- and DMBA-induced experimental oral carcinogenesis with 10,152 and 6306 citations, respectively. The common distinctive ...
REVIEW 4-Nitroquinoline-1-oxide induced experimental oral carcinogenesis Deepak Kanojia, Milind M. Vaidya * Biochemistry and Cell Biology, Tata Memorial Hospital, Cancer Research Institute,
Use of 4NQO animal models for the development of biomarkers. 4NQO mediated experimental carcinogenesis is similar to human oral carcinogenesis. Therefore, it has been widely used for the possible development of biomarkers for human oral cancer. Proteins of signal transduction pathways like apoptosis, cell cycle, cell-cell signaling and other ...
Materials and methods. As per the methodology described previously, 9, 10 all the papers on 4NQO- and DMBA-induced experimental oral carcinogenesis were retrieved on 12 May 2023 from the Scopus database. According to the search strategy described in Supplementary Table S1, we used medical subject term "4NQO" or "DMBA" and the respective synonyms in the title/abstract to retrieve the ...
coal tar, 20 methyl cholanthrene (20MC), 9,10-dimethyl-1,2-benzanthracene (DMBA) and 4-. nitroquinoline-1-oxide (4NQO) have been used in experimental oral carcinogenesis. However, 4NQO is the ...
Meanwhile, chemically induced mouse models of oral carcinogenesis were constructed with 4-nitroquinolone-N-oxide induction. ... and an increased ratio of stem-like exhausted T cells and partially exhausted T cells were detected in the experimental groups. Besides, the expression of immune checkpoint markers (PDCD1, CTLA4 and HAVCR2) was ...
However, 4NQO is the preferred carcinogen apart from DMBA in the development of experimental oral carcinogenesis. 4NQO is a water soluble carcinogen, which induces tumors predominantly in the oral cavity. It produces all the stages of oral carcinogenesis and several lines of evidences suggest that similar histological as well as molecular ...
Experimental design for studying the effect of pre and concurrent treatment of different doses of black tea-derived PBPs extract on DMBA induced oral carcinogenesis in the hamster model. 6-8 ...
Apoptotic avoidance is one of the foremost characteristic features of tumour cells. Apoptotic induction in cancer cells could thus help to identify new anticancer agents from the natural products. The present study has taken an effort to investigate the apoptotic efficacy of myrtenal, a monoterpene, in 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinoma in male golden Syrian hamsters.
Mammary carcinogenesis was induced using 80 mg/kg of 7,12-dimethylbenzanthracene (DMBA) administered by oral gavage. One hundred-fifty days post-DMBA induction, estrogen receptor-α (ER-α) levels were determined in the experimental rats before treatment with KV commenced.
The preclinical data obtained with this experimental model or oral carcinogenesis provide knowledge that will help us to design effective trials for prevention treatment of patients considered at high risk of developing OSCCs. ... Vaidya MM. 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol. 2006; 42:655-67 ...
The primary aim of this study was to evaluate the activation of the PERP and Akt oncogenes in the induction of skin cancer in FVB/N mice by a stepwise chemical process. Forty four-week-old female FVB/N mice were randomly divided into a control group (n = 8) and two experimental groups (group A: n = 16, group B: n = 16). In the study, the groups were subjected to a two-stage carcinogenesis ...
Mammary carcinogenesis was induced using 80 mg/kg of 7,12-dimethylbenzanthracene (DMBA) administered by oral gavage. One hundred-fifty days post-DMBA induction, estrogen receptor-α (ER-α) levels were determined in the experimental rats before treatment with KV commenced.