research design qualitative quantitative and mixed methods approaches 2nd edition

Research Design

Second edition quantitative, qualitative, mixed methods, arts-based, and community-based participatory research approaches, patricia leavy.

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Research design: qualitative, quantitative and mixed methods approaches Research design: qualitative, quantitative and mixed methods approaches Creswell John W Sage 320 £29 0761924426 0761924426 [Formula: see text]

PMID: 28718745
DOI: 10.7748/nr.12.1.82.s2

The second edition of Creswell's book has been significantly revised and updated. The author clearly sets out three approaches to research: quantitative, qualitative and mixed methods. As someone who has used mixed methods in my research, it is refreshing to read a textbook that addresses this. The differences between the approaches are clearly identified and a rationale for using each methodological stance provided.

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Research design: qualitative, quantitative, and mixed methods approaches / sixth edition

Published: 15 November 2023
Volume 58 , pages 1011–1013, ( 2024 )

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research design qualitative quantitative and mixed methods approaches 2nd edition

James P. Takona ORCID: orcid.org/0009-0001-4591-8136 1

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This review examines John W. Creswell and David Creswell’s sixth edition, which covers the most popular research methods, offering readers a comprehensive understanding and practical guidance in qualitative, quantitative, and mixed methods. The review includes observations on existing drawbacks, gaps, and ideas on potential areas for improvement in the book. The book is an excellent entry point for understanding the three broad research designs. It stands out for incorporating various methods and empowering researchers to effectively align them with specific research questions, objectives, and philosophical underpinnings. However, it could be further refined by incorporating newer research approaches and expanding practical aspects such as data collection, sampling strategies, and data analysis techniques. With these improvements, the sixth edition could further solidify its position as a comprehensive and accessible guide adeptly catering to researchers, educators, and students. Despite the book’s many strengths, there are opportunities for refinement in future editions, incorporating newer approaches to research designs and expanding practical aspects such as data collection, sampling strategies, and data analysis techniques. This review highlights that, with these suggested improvements, future editions could not only maintain but also enhance the text’s comprehensive and accessible nature, further solidifying its status as a vital resource for researchers, educators, and student.

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Takona, J.P. Research design: qualitative, quantitative, and mixed methods approaches / sixth edition. Qual Quant 58 , 1011–1013 (2024). https://doi.org/10.1007/s11135-023-01798-2

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Published : 15 November 2023

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Research Design Qualitative, Quantitative, And Mixed Methods Approaches ( 4th Ed.)

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Research Design: Qualitative, Quantitative, and Mixed Methods Approaches

You are here, student resources, welcome to the companion website.

Welcome to the SAGE edge site for Research Design, Fifth Edition .

The SAGE edge site for Research Design by John W. Creswell and J. David Creswell offers a robust online environment you can access anytime, anywhere, and features an array of free tools and resources to keep you on the cutting edge of your learning experience.

This best-selling text pioneered the comparison of qualitative, quantitative, and mixed methods research design. For all three approaches, John W. Creswell and new co-author J. David Creswell include a preliminary consideration of philosophical assumptions, key elements of the research process, a review of the literature, an assessment of the use of theory in research applications, and reflections about the importance of writing and ethics in scholarly inquiry.

The Fifth Edition includes more coverage of: epistemological and ontological positioning in relation to the research question and chosen methodology; case study, PAR, visual and online methods in qualitative research; qualitative and quantitative data analysis software; and in quantitative methods more on power analysis to determine sample size, and more coverage of experimental and survey designs; and updated with the latest thinking and research in mixed methods.

Acknowledgments

We gratefully acknowledge John W. Creswell and J. David Creswell for writing an excellent text. Special thanks are also due to Tim Guetterman of the University of Michigan, Shannon Storch of the University of Creighton, and Tiffany J. Davis of the University of Houston for developing the ancillaries on this site.

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Research Design: Qualitative, Quantitative, and Mixed Methods Approaches

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Welcome to the companion website for Research Design , Fourth Edition, by John W. Creswell. The resources on the site have been specifically designed to support your study.

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The eagerly anticipated Fourth Edition of the title that pioneered the comparison of qualitative, quantitative, and mixed methods research design is here! For all three approaches, Creswell includes a preliminary consideration of philosophical assumptions, a review of the literature, an assessment of the use of theory in research approaches, and reflections about the importance of writing and ethics in scholarly inquiry. He also presents the key elements of the research process, giving specific attention to each approach. The Fourth Edition includes extensively revised mixed methods coverage, increased coverage of ethical issues in research, and an expanded emphasis on worldview perspectives.

Acknowledgments

We gratefully acknowledge John W. Creswell for writing an excellent text. Special thanks are also due to Karen Thomas-Brown, Angela Heads, and Rosemary Gillett-Karam for updating and creating the ancillaries on this site

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Review Article
Published: 22 March 2024

Drug-resistant tuberculosis: a persistent global health concern

Maha Farhat ORCID: orcid.org/0000-0002-3871-5760 1 , 2 ,
Helen Cox 3 na1 ,
Marwan Ghanem 1 na1 ,
Claudia M. Denkinger 4 , 5 ,
Camilla Rodrigues 6 ,
Mirna S. Abd El Aziz 4 ,
Handaa Enkh-Amgalan 7 ,
Debrah Vambe 8 ,
Cesar Ugarte-Gil 9 ,
Jennifer Furin 10 &
Madhukar Pai ORCID: orcid.org/0000-0003-3667-4536 11

Nature Reviews Microbiology ( 2024 ) Cite this article

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Antimicrobial resistance
Bacterial evolution
Clinical microbiology
Infectious-disease epidemiology

Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-attributable deaths worldwide and is driven by both ongoing resistance acquisition and person-to-person transmission. Poor outcomes are exacerbated by late diagnosis and inadequate access to effective treatment. Advances in rapid molecular testing have recently improved the diagnosis of TB and drug resistance. Next-generation sequencing of Mycobacterium tuberculosis has increased our understanding of genetic resistance mechanisms and can now detect mutations associated with resistance phenotypes. All-oral, shorter drug regimens that can achieve high cure rates of drug-resistant TB within 6–9 months are now available and recommended but have yet to be scaled to global clinical use. Promising regimens for the prevention of drug-resistant TB among high-risk contacts are supported by early clinical trial data but final results are pending. A person-centred approach is crucial in managing drug-resistant TB to reduce the risk of poor treatment outcomes, side effects, stigma and mental health burden associated with the diagnosis. In this Review, we describe current surveillance of drug-resistant TB and the causes, risk factors and determinants of drug resistance as well as the stigma and mental health considerations associated with it. We discuss recent advances in diagnostics and drug-susceptibility testing and outline the progress in developing better treatment and preventive therapies.

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Multidrug-resistant tuberculosis

Rifampicin Resistant Tuberculosis in Lesotho: Diagnosis, Treatment Initiation and Outcomes

Global burden of disease due to rifampicin-resistant tuberculosis: a mathematical modeling analysis

Peto, H. M., Pratt, R. H., Harrington, T. A., LoBue, P. A. & Armstrong, L. R. Epidemiology of extrapulmonary tuberculosis in the United States, 1993–2006. Clin. Infect. Dis. 49 , 1350–1357 (2009).

Article PubMed Google Scholar

WHO Consolidated Guidelines on Tuberculosis. Module 4: Treatment — Drug-resistant Tuberculosis Treatment, 2022 Update. World Health Organization https://www.who.int/publications/i/item/9789240063129 (2022).

WHO Consolidated Guidelines on Tuberculosis. Module 4: Treatment — Drug-susceptible Tuberculosis Treatment. World Health Organization https://www.who.int/publications/i/item/9789240048126 (2022).

WHO Consolidated Guidelines on Tuberculosis. Module 3: Diagnosis — Rapid Diagnostics For Tuberculosis Detection, 2021 Update. World Health Organization https://www.who.int/publications/i/item/9789240029415 (2021).

Cohen, K. A., Manson, A. L., Desjardins, C. A., Abeel, T. & Earl, A. M. Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges. Genome Med. 11 , 45 (2019).

Article PubMed PubMed Central Google Scholar

Cohen, K. A. et al. Extensive global movement of multidrug-resistant Mycobacterium tuberculosis strains revealed by whole-genome analysis. Thorax 74 , 882–889 (2019).

Short-course chemotherapy in pulmonary tuberculosis: a controlled trial by the British Thoracic and Tuberculosis Association. Lancet 305 , 119–124 (1975).

Zhang, Y. The magic bullets and tuberculosis drug targets. Annu. Rev. Pharmacol. Toxicol. 45 , 529–564 (2005).

Article CAS PubMed Google Scholar

Global Tuberculosis Report 2022. World Health Organization https://www.who.int/publications/i/item/9789240061729 (2022).

Global Tuberculosis Report 2021. World Health Organization https://www.who.int/publications/i/item/9789240037021 (2021).

Boehme, C. C. et al. Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med. 363 , 1005–1015 (2010).

Article CAS PubMed PubMed Central Google Scholar

The Use of Molecular Line Probe Assay for the Detection of Resistance to Isoniazid and Rifampicin: Policy Update. World Health Organization https://www.who.int/publications/i/item/9789241511261 (2016).

Dixit, A. et al. Estimation of country-specific tuberculosis antibiograms using genomic data. Preprint at medRxiv https://doi.org/10.1101/2021.09.23.21263991 (2021).

Article Google Scholar

O’Connor, C. & Brady, M. F. Isoniazid. StatPearls [Internet] https://pubmed.ncbi.nlm.nih.gov/32491549/ (updated 8 April 2022).

Yee, D. et al. Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am. J. Respir. Crit. Care Med. 167 , 1472–1477 (2003).

Murray, J. F., Schraufnagel, D. E. & Hopewell, P. C. Treatment of tuberculosis: a historical perspective. Ann. Am. Thorac. Soc. 12 , 1749–1759 (2015).

Jacobson, K. R. et al. Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa. Clin. Infect. Dis. 53 , 369–372 (2011).

Ahmad, N., Ahuja, S. & Akkerman, O. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet 392 , 821–834 (2018).

Stagg, H. R. et al. Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance. Eur. Respir. J. 54 , 1900982 (2019).

WHO Treatment Guidelines for Isoniazid-resistant Tuberculosis: Supplement to the WHO Treatment Guidelines for Drug-resistant Tuberculosis. World Health Organization https://www.who.int/publications/i/item/9789241550079 (2018).

Meeting Report of the WHO Expert Consultation on the Definition of extensively Drug-Resistant Tuberculosis, 27-29 October 2020. World Health Organization https://www.who.int/publications/i/item/9789240018662 (2021).

Global Tuberculosis Report 2023. World Health Organization https://www.who.int/publications/i/item/9789240083851 (2023).

Murray, C. J. et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399 , 629–655 (2022).

Article CAS Google Scholar

Knight, G. M., McQuaid, C. F., Dodd, P. J. & Houben, R. Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling. Lancet Infect. Dis. 19 , 903–912 (2019).

WHO Global Task Force on TB Impact Measurement: Report of a Subgroup Meeting on Methods Used by WHO to Estimate TB Disease Burden, 11-12 May 2022, Geneva, Switzerland. World Health Organization https://www.who.int/publications/i/item/9789240057647 (2022).

Global Tuberculosis Report 2015. World Health Organization https://www.who.int/publications/i/item/9789241565059 (2015).

Global Tuberculosis Report 2020. World Health Organization https://www.who.int/publications/i/item/9789240013131 (2020).

Villegas, L. et al. Prevalence, risk factors, and treatment outcomes of isoniazid- and rifampicin-mono-resistant pulmonary tuberculosis in Lima, Peru. PLoS ONE 11 , e0152933 (2016).

Sharling, L., Marks, S. M., Goodman, M., Chorba, T. & Mase, S. Rifampin-resistant tuberculosis in the United States, 1998-2014. Clin. Infect. Dis. 70 , 1596–1605 (2019).

Ismail, N. A. et al. Prevalence of drug-resistant tuberculosis and imputed burden in South Africa: a national and sub-national cross-sectional survey. Lancet Infect. Dis. 18 , 779–787 (2018).

Dean, A. S. Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: a multicountry analysis of cross-sectional data. PLoS Med. 17 , e1003008 (2020).

Subbaraman, R., Jhaveri, T. & Nathavitharana, R. R. Closing gaps in the tuberculosis care cascade: an action-oriented research agenda. J. Clin. Tuberc. Mycobact. Dis. 19 , 100144 (2020).

Google Scholar

Subbaraman, R. et al. Constructing care cascades for active tuberculosis: a strategy for program monitoring and identifying gaps in quality of care. PLoS Med. 16 , e1002754 (2019).

Naidoo, P. et al. The South African tuberculosis care cascade: estimated losses and methodological challenges. J. Infect. Dis. 216 , S702–S713 (2017).

Subbaraman, R. et al. The tuberculosis cascade of care in India’s public sector: a systematic review and meta-analysis. PLoS Med. 13 , e1002149 (2016).

Migliori, G. B. et al. Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study. Eur. Respir. J. 58 , 2101786 (2021).

Daniels, B. et al. Use of standardised patients to assess quality of healthcare in Nairobi, Kenya: a pilot, cross-sectional study with international comparisons. BMJ Glob. Health 2 , e000333 (2017).

Daniels, B., Kwan, A. & Pai, M. Lessons on the quality of tuberculosis diagnosis from standardized patients in China, India, Kenya, and South. Afr. J. Clin. Tuberc. Mycobact. Dis. 16 , 100109 (2019).

Boffa, J. et al. Quality of care for tuberculosis and HIV in the private health sector: a cross-sectional, standardised patient study in South Africa. BMJ Glob. Health 6 , e005250 (2021).

Kwan, A. et al. Variations in the quality of tuberculosis care in urban India: a cross-sectional, standardized patient study in two cities. PLoS Med. 15 , e1002653 (2018).

Daniels, B. et al. Tuberculosis diagnosis and management in the public versus private sector: a standardised patients study in Mumbai, India. BMJ Glob. Health 7 , 009657 (2022).

Demers, A. M. et al. Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial. BMC Infect. Dis. 21 , 205 (2021).

Step up for TB 2020 report: Tuberculosis Policies in 37 Countries. Médecins Sans Frontières & Stop TB Partnership https://msfaccess.org/step-tb-tb-policies-37-countries-4th-ed (2020).

Omar, S. V., Ismail, F., Ndjeka, N., Kaniga, K. & Ismail, N. A. Bedaquiline-resistant tuberculosis associated with Rv0678 mutations. N. Engl. J. Med. 386 , 93–94 (2022).

Ismail, N. A. et al. Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a cross-sectional and longitudinal study. Lancet Infect. Dis. 22 , 496–506 (2022).

Azimi, T. et al. Linezolid resistance in multidrug-resistant Mycobacterium tuberculosis : a systematic review and meta-analysis. Front. Pharmacol. 13 , 955050 (2022).

Chesov, E. et al. Emergence of bedaquiline resistance in a high tuberculosis burden country. Eur. Respir. J. 59 , 2100621 (2022).

Mallick, J. S., Nair, P., Abbew, E. T., Van Deun, A. & Decroo, T. Acquired bedaquiline resistance during the treatment of drug-resistant tuberculosis: a systematic review. JAC Antimicrob. Resist. 4 , dlac029 (2022).

Jenkins, H. E. & Yuen, C. M. The burden of multidrug-resistant tuberculosis in children. Int. J. Tuberc. Lung Dis. 22 , 3–6 (2018).

WHO Consolidated Guidelines on Tuberculosis, Module 5: Management of Tuberculosis in children and Adolescents. World Health Organization https://www.who.int/publications/i/item/9789240046764 (2022).

Dodd, P. J., Mafirakureva, N., Seddon, J. A. & McQuaid, C. F. The global impact of household contact management for children on multidrug-resistant and rifampicin-resistant tuberculosis cases, deaths, and health-system costs in 2019: a modelling study. Lancet Glob. Health 10 , 1034–1044 (2022).

Dookie, N., Rambaran, S., Padayatchi, N., Mahomed, S. & Naidoo, K. Evolution of drug resistance in Mycobacterium tuberculosis : a review on the molecular determinants of resistance and implications for personalized care. J. Antimicrob. Chemother. 73 , 1138–1151 (2018).

Casali, N. et al. Evolution and transmission of drug-resistant tuberculosis in a Russian population. Nat. Genet. 46 , 279–286 (2014).

Cohen, K. A. et al. Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal. PLoS Med. 12 , e1001880 (2015).

Jiang, Q. et al. The evolution and transmission dynamics of multidrug-resistant tuberculosis in an isolated high-plateau population of Tibet, China. Microbiol. Spectr. 11 , e03991-22 (2023).

Ektefaie, Y., Dixit, A., Freschi, L. & Farhat, M. R. Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences. Lancet Microbe 2 , e96–e104 (2021).

Auld, S. C. et al. Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities. Eur. Respir. J. 52 , 1800246 (2018).

Kendall, E. A., Fofana, M. O. & Dowdy, D. W. Burden of transmitted multidrug resistance in epidemics of tuberculosis: a transmission modelling analysis. Lancet Respir. Med. 3 , 963–972 (2015).

Yang, C. et al. Transmission of multidrug-resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational study using whole-genome sequencing and epidemiological investigation. Lancet Infect. Dis. 17 , 275–284 (2017).

Becerra, M. C. et al. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis : prospective cohort study. BMJ 367 , l5894 (2019).

Atre, S. R. et al. Tuberculosis pathways to care and transmission of multidrug resistance in India. Am. J. Respir. Crit. Care Med. 205 , 233–241 (2022).

El Halabi, J. et al. Measuring health-care delays among privately insured patients with tuberculosis in the USA: an observational cohort study. Lancet Infect. Dis. 21 , 1175–1183 (2021).

Odone, A. et al. Acquired and transmitted multidrug resistant tuberculosis: the role of social determinants. PLoS ONE 11 , e0146642 (2016).

Bayer, R. & Wilkinson, D. Directly observed therapy for tuberculosis: history of an idea. Lancet 345 , 1545–1548 (1995).

Pasipanodya, J. G., Srivastava, S. & Gumbo, T. Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of antituberculosis therapy. Clin. Infect. Dis. 55 , 169–177 (2012).

Srivastava, S., Pasipanodya, J. G., Meek, C., Leff, R. & Gumbo, T. Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability. J. Infect. Dis. 204 , 1951–1959 (2011).

McKay, B., Castellanos, M., Ebell, M., Whalen, C. C. & Handel, A. An attempt to reproduce a previous meta-analysis and a new analysis regarding the impact of directly observed therapy on tuberculosis treatment outcomes. PLoS ONE 14 , e0217219 (2019).

Manson, A. L. et al. Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance. Nat. Genet. 49 , 395–402 (2017).

Dreyer, V. et al. High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region. Genome Med. 14 , 95 (2022).

Cox, H. et al. Potential contribution of HIV during first-line tuberculosis treatment to subsequent rifampicin-monoresistant tuberculosis and acquired tuberculosis drug resistance in South Africa: a retrospective molecular epidemiology study. Lancet Microbe 2 , e584–e593 (2021).

Wang, Z. et al. Epidemiological characteristics and risk factors of multidrug-resistant tuberculosis in Luoyang, China. Front. Public Health 11 , 1117101 (2023).

Hang, N. T. L. et al. Primary drug-resistant tuberculosis in Hanoi, Viet Nam: present status and risk factors. PLoS ONE 8 , e71867 (2013).

Vashakidze, L. et al. Prevalence and risk factors for drug resistance among hospitalized tuberculosis patients in Georgia. Int. J. Tuberc. Lung Dis. 13 , 1148–1153 (2009).

CAS PubMed Google Scholar

Andrews, J. R. et al. Predictors of multidrug-and extensively drug-resistant tuberculosis in a high HIV prevalence community. PLoS ONE 5 , e15735 (2010).

Mesfin, E. A. et al. Drug-resistance patterns of Mycobacterium tuberculosis strains and associated risk factors among multi drug-resistant tuberculosis suspected patients from Ethiopia. PLoS ONE 13 , e0197737 (2018).

Mbuh, T. P. et al. Predictors of drug-resistant tuberculosis among high-risk population diagnosed under national program conditions in the Littoral region, Cameroon. BioMed. Res. Int. 2021 , 8817442 (2021).

Skrahina, A. et al. Multidrug-resistant tuberculosis in Belarus: the size of the problem and associated risk factors. Bull. World Health Organ. 91 , 36–45 (2013).

Urrego, J. et al. The impact of ventilation and early diagnosis on tuberculosis transmission in Brazilian prisons. Am. J. Trop. Med. Hyg. 93 , 739–746 (2015).

Kerubo, G., Amukoye, E., Niemann, S. & Kariuki, S. Drug susceptibility profiles of pulmonary Mycobacterium tuberculosis isolates from patients in informal urban settlements in Nairobi, Kenya. BMC Infect. Dis. 16 , 583 (2016).

Oliveira, O. et al. Using Bayesian spatial models to map and to identify geographical hotspots of multidrug-resistant tuberculosis in Portugal between 2000 and 2016. Sci. Rep. 10 , 16646 (2020).

Jenkins, H. E. et al. Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country. Eur. Respir. J. 42 , 1291–1301 (2013).

Alene, K. A., Viney, K., McBryde, E. S. & Clements, A. C. A. Spatial patterns of multidrug resistant tuberculosis and relationships to socio-economic, demographic and household factors in northwest Ethiopia. PLoS ONE 12 , e0171800 (2017).

Paleckyte, A., Dissanayake, O., Mpagama, S., Lipman, M. C. & McHugh, T. D. Reducing the risk of tuberculosis transmission for HCWs in high incidence settings. Antimicrob. Resist. Infect. Control 10 , 106 (2021).

Escombe, A. R. et al. Tuberculosis transmission risk and infection control in a hospital emergency department in Lima, Peru. Int. J. Tuberc. Lung Dis. 14 , 1120–1126 (2010).

Telisinghe, L. et al. High tuberculosis prevalence in a South African prison: the need for routine tuberculosis screening. PLoS ONE 9 , e87262 (2014).

Dheda, K. et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir. Med. 5 , 291–360 (2017).

Houben, R. M. G. J. & Glynn, J. R. A systematic review and meta-analysis of molecular epidemiological studies of tuberculosis: development of a new tool to aid interpretation. Trop. Med. Int. Health 14 , 892–909 (2009).

Chen, S. et al. Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case-control study. Int. J. Infect. Dis. 17 , e1116-20 (2013).

Pradipta, I. S., Forsman, L. D., Bruchfeld, J., Hak, E. & Alffenaar, J. W. Risk factors of multidrug-resistant tuberculosis: a global systematic review and meta-analysis. J. Infect. 77 , 469–478 (2018).

Lomtadze, N. et al. Prevalence and risk factors for multidrug-resistant tuberculosis in the Republic of Georgia: a population-based study. Int. J. Tuberc. Lung Dis. 13 , 68–73 (2009).

Lee, E. G. et al. Age-stratified anti-tuberculosis drug resistance profiles in South Korea: a multicenter retrospective study. BMC Infect. Dis. 20 , 446 (2020).

Behr, M. A., Edelstein, P. H. & Ramakrishnan, L. Revisiting the timetable of tuberculosis. BMJ 362 , k2738 (2018).

Oladimeji, O. et al. Gender and drug-resistant tuberculosis in Nigeria. Trop. Med. Infect. Dis. 8 , 104 (2023).

McQuaid, C. F., Horton, K. C., Dean, A. S., Knight, G. M. & White, R. G. The risk of multidrug-or rifampicin-resistance in males versus females with tuberculosis. Eur. Respir. J. 56 , 2000626 (2020).

O’Donnell, M. R. et al. Extensively drug-resistant tuberculosis in women, KwaZulu-Natal, South Africa. Emerg. Infect. Dis. 17 , 1942–1945 (2011).

Gandhi, N. R. et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368 , 1575–1580 (2006).

Kolla, B. P., Oesterle, T., Gold, M., Southwick, F. & Rummans, T. Infectious diseases occurring in the context of substance use disorders: a concise review. J. Neurol. Sci. 411 , 116719 (2020).

Soboka, M. et al. Substance use disorders and adherence to antituberculosis medications in Southwest Ethiopia: a prospective cohort study. BMJ Open 11 , e043050 (2021).

Mekonnen, H. S. & Azagew, A. W. Non-adherence to anti-tuberculosis treatment, reasons and associated factors among TB patients attending at Gondar town health centers, Northwest Ethiopia. BMC Res. Notes 11 , 691 (2018).

Chaves Torres, N. M., Quijano Rodríguez, J. J., Porras Andrade, P. S., Arriaga, M. B. & Netto, E. M. Factors predictive of the success of tuberculosis treatment: a systematic review with meta-analysis. PLoS ONE 14 , e0226507 (2019).

Dixit, A. et al. Modern lineages of Mycobacterium tuberculosis were recently introduced in Western India and demonstrate increased transmissibility. Preprint at medRxiv https://doi.org/10.1101/2022.01.04.22268645 (2022).

Casali, N. et al. Microevolution of extensively drug-resistant tuberculosis in Russia. Genome Res. 22 , 735–745 (2012).

Gygli, S. M. et al. Publisher Correction: prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis . Nat. Med. 27 , 1308–1308 (2021).

Loiseau, C. et al. The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot. Nat. Commun. 14 , 1988 (2023).

Gygli, S. M., Borrell, S., Trauner, A. & Gagneux, S. Antimicrobial resistance in Mycobacterium tuberculosis : mechanistic and evolutionary perspectives. FEMS Microbiol. Rev. 41 , 354–373 (2017).

Li, S. et al. CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis . Nat. Microbiol. 7 , 766–779 (2022).

Nguyen, L. & Pieters, J. Mycobacterial subversion of chemotherapeutic reagents and host defense tactics: challenges in tuberculosis drug development. Annu. Rev. Pharmacol. Toxicol. 49 , 427–453 (2009).

Morris, R. P. et al. Ancestral antibiotic resistance in Mycobacterium tuberculosis . Proc. Natl Acad. Sci. USA 102 , 12200–12205 (2005).

Mailaender, C. et al. The MspA porin promotes growth and increases antibiotic susceptibility of both Mycobacterium bovis BCG and Mycobacterium tuberculosis . Microbiology 150 , 853–864 (2004).

Rodriguez-Rivera, F. P., Zhou, X., Theriot, J. A. & Bertozzi, C. R. Visualization of mycobacterial membrane dynamics in live cells. J. Am. Chem. Soc. 139 , 3488–3495 (2017).

Madsen, C. T. et al. Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in Mycobacterium tuberculosis . J. Biol. Chem. 280 , 38942–38947 (2005).

Wang, F., Cassidy, C. & Sacchettini, J. C. Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to β-lactam antibiotics. Antimicrob. Agents Chemother. 50 , 2762–2771 (2006).

Chambers, H. F., Kocagoz, T., Sipit, T., Turner, J. & Hopewell, P. C. Activity of amoxicillin/clavulanate in patients with tuberculosis. Clin. Infect. Dis. 26 , 874–877 (1998).

Donald, P. R. & Sirge, F. A. Early bactericidal activity of amoxicillin in combination with clavulanic acid in patients with sputum smear-positive pulmonary tuberculosis. Scand. J. Infect. Dis. 33 , 466–469 (2001).

Hugonnet, J.-E., Tremblay, L. W., Boshoff, H. I., Barry, C. E. & Blanchard, J. S. Meropenem-clavulanate is effective against extensively drug-desistant Mycobacterium tuberculosis . Science 323 , 1215–1218 (2009).

Vargas, R. Jr et al. Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex. Proc. Natl Acad. Sci. USA 120 , e2301394120 (2023).

Vargas, R. Jr Role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex. Antimicrob. Agents Chemother. 65 , e0116421 (2021).

Farhat, M. R. et al. Genetic determinants of drug resistance in Mycobacterium tuberculosis and their diagnostic value. Am. J. Respir. Crit. Care Med. 194 , 621–630 (2016).

Nebenzahl-Guimaraes, H., Jacobson, K. R., Farhat, M. R. & Murray, M. B. Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis . J. Antimicrob. Chemother. 69 , 331–342 (2013).

Kadura, S. et al. Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid. J. Antimicrob. Chemother. 75 , 2031–2043 (2020).

Zhang, Y. & Yew, W. W. Mechanisms of drug resistance in Mycobacterium tuberculosis . Int. J. Tuberc. Lung Dis. 13 , 1320–1330 (2009).

Green, A. G. et al. Analysis of genome-wide mutational dependence in naturally evolving Mycobacterium tuberculosis populations. Mol. Biol. Evol. 40 , msad131 (2023).

Barilar, I. et al. Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach. Nat. Commun. 15 , 488 (2024).

Farhat, M. R. et al. GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions. Nat. Commun. 10 , 2128 (2019).

Walker, T. M. et al. The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis. Lancet Microbe 3 , e265–e273 (2022).

Ghodousi, A. et al. Isoniazid resistance in Mycobacterium tuberculosis is a heterogeneous phenotype composed of overlapping MIC distributions with different underlying resistance mechanisms. Antimicrob. Agents Chemother. 63 , e00092-19 (2019).

Spitaleri, A., Ghodousi, A., Miotto, P. & Cirillo, D. M. Whole genome sequencing in Mycobacterium tuberculosis . Ann. Transl. Med. 7 , S197 (2019).

Farhat, M. R. et al. Gyrase mutations are associated with variable levels of fluoroquinolone resistance in Mycobacterium tuberculosis . J. Clin. Microbiol. 54 , 727–733 (2016).

Chen, M. L. et al. Beyond multidrug resistance: leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction. EBioMedicine 43 , 356–369 (2019).

Green, A. G. et al. A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis . Nat. Commun. 13 , 3817 (2022).

Yang, Y. et al. Machine learning for classifying tuberculosis drug-resistance from DNA sequencing data. Bioinformatics 34 , 1666–1671 (2018).

Gröeschel, M. I. et al. GenTB: a user-friendly genome-based predictor for tuberculosis resistance powered by machine learning. Genome Med. 13 , 138 (2021).

Safi, H. et al. Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance. Proc. Natl Acad. Sci. USA 116 , 19665–19674 (2019).

Hicks, N. D. et al. Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nat. Microbiol. 3 , 1032–1042 (2018).

Liu, Q. et al. Tuberculosis treatment failure associated with evolution of antibiotic resilience. Science 378 , 1111–1118 (2022).

Kreutzfeldt, K. M. et al. CinA mediates multidrug tolerance in Mycobacterium tuberculosis . Nat. Commun. 13 , 2203 (2022).

Martini, M. C. et al. Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis . PLoS Pathog. 18 , e1010705 (2022).

Andersson, D. I., Nicoloff, H. & Hjort, K. Mechanisms and clinical relevance of bacterial heteroresistance. Nat. Rev. Microbiol. 17 , 479–496 (2019).

Vargas, R. et al. In-host population dynamics of Mycobacterium tuberculosis complex during active disease. eLife 10 , e61805 (2021).

Nimmo, C. et al. Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment. EBioMedicine 55 , 102747 (2020).

Engelthaler, D. M. et al. Minority Mycobacterium tuberculosis genotypic populations as an indicator of subsequent phenotypic resistance. Am. J. Respir. Cell Mol. Biol. 61 , 789–791 (2019).

WHO Standard: Universal Access to Rapid Tuberculosis Diagnostics. World Health Organization https://www.who.int/publications/i/item/9789240071315 (2023).

Report of the 16th Meeting of the Strategic and Technical Advisory Group for Tuberculosis 2016. World Health Organization https://www.who.int/publications/m/item/report-of-the-16th-meeting-of-the-strategic-and-technical-advisory-group-for-tb (2016).

Jacobson, K. R. et al. Implications of failure to routinely diagnose resistance to second-line drugs in patients with rifampicin-resistant tuberculosis on Xpert MTB/RIF: a multisite observational study. Clin. Infect. Dis. 64 , 1502–1508 (2017).

Oga-Omenka, C. et al. Factors influencing diagnosis and treatment initiation for multidrug-resistant/rifampicin-resistant tuberculosis in six sub-Saharan African countries: a mixed-methods systematic review. BMJ Glob. Health 5 , e002280 (2020).

Svadzian, A., Sulis, G., Gore, G., Pai, M. & Denkinger, C. M. Differential yield of universal versus selective drug susceptibility testing of patients with tuberculosis in high-burden countries: a systematic review and meta-analysis. BMJ Glob. Health 5 , e003438 (2020).

Kim, S. J. Drug-susceptibility testing in tuberculosis: methods and reliability of results. Eur. Respir. J. 25 , 564–569 (2005).

Technical Manual for Drug Susceptibility Testing of Medicines Used in the Treatment of Tuberculosis. World Health Organization https://www.who.int/publications/i/item/9789241514842 (2018).

Yu, H.-J. et al. Performance evaluation of the BACTEC MGIT 960 system for rifampin drug-susceptibility testing of Mycobacterium tuberculosis using the current WHO critical concentration. J. Clin. Microbiol. 61 , e01086-22 (2023).

Shea, J. et al. Low-level rifampin resistance and rpoB mutations in Mycobacterium tuberculosis : an analysis of whole-genome sequencing and drug susceptibility test data in New York. J. Clin. Microbiol. 59 , e01885-20 (2021).

Torrea, G. et al. Variable ability of rapid tests to detect Mycobacterium tuberculosis rpoB mutations conferring phenotypically occult rifampicin resistance. Sci. Rep. 9 , 11826 (2019).

Automated Real-time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB/RIF System: Policy Statement. World Health Organization https://www.who.int/publications/i/item/9789241501545 (2011).

Rapid Implementation of the Xpert MTB/RIF Diagnostic Test: Technical and Operational “How-to”; Practical Considerations. World Health Organization https://www.who.int/publications/i/item/9789241501569 (2011).

Dorman, S. E. et al. Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect. Dis. 18 , 76–84 (2018).

Albert, H. et al. Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better? Eur. Respir. J. 48 , 516–525 (2016).

Zifodya, J. S. et al. Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis. Cochrane Database Syst. Rev. 2021 , CD009593 (2021).

Penn-Nicholson, A. et al. A prospective multicentre diagnostic accuracy study for the Truenat tuberculosis assays. Eur. Respir. J. 58 , 2100526 (2021).

Gomathi, N. S. et al. Validation of an indigenous assay for rapid molecular detection of rifampicin resistance in presumptive multidrug-resistant pulmonary tuberculosis patients. Indian J. Med. Res. 152 , 482–489 (2020).

Molbio Diagnostics: Molbio launches Truenat MTB-INH test for drug resistance in TB patients. Health News, ET HealthWorld https://health.economictimes.indiatimes.com/news/diagnostics/molbio-launches-truenat-mtb-inh-test-for-drug-resistance-in-tb-patients/96963161 (2023).

Theron, G. et al. Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. Lancet 383 , 424–435 (2014).

Yoon, C. et al. Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda. PLoS ONE 7 , e48599 (2012).

Di Tanna, G. L. et al. Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis. Lancet Glob. Health 7 , e191–e199 (2019).

Churchyard, G. J. et al. Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF. Lancet Glob. Health 3 , 450–457 (2015).

Cattamanchi, A. et al. Multicomponent strategy with decentralized molecular testing for tuberculosis. N. Engl. J. Med. 385 , 2441–2450 (2021).

Penn-Nicholson, A. et al. Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study. Lancet Infect. Dis. 22 , 242–249 (2022).

Cao, Y. et al. Xpert MTB/XDR: a 10-color reflex assay suitable for point-of-care settings to detect isoniazid, fluoroquinolone, and second-line-injectable-drug resistance directly from Mycobacterium tuberculosis-positive sputum. J. Clin. Microbiol. 59 , e02314-20 (2021).

De Vos, M. et al. Comparative analytical evaluation of four centralized platforms for the detection of Mycobacterium tuberculosis complex and resistance to rifampicin and isoniazid. J. Clin. Microbiol. 59 , e02168-20 (2021).

Meaza, A. et al. Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples. BMC Infect. Dis. 17 , 280 (2017).

Nathavitharana, R. R. et al. Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis. Eur. Respir. J. 49 , 1601075 (2017).

Driesen, M. et al. Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment. Clin. Microbiol. Infect. 24 , 60–64 (2018).

Willby, M. J. et al. Detection of Mycobacterium tuberculosis pncA mutations by the Nipro Genoscholar PZA-TB II assay compared to conventional sequencing. Antimicrob. Agents Chemother. 62 , e01871-17 (2018).

Catalogue of Mutations in Mycobacterium tuberculosis Complex and their Association with Drug Resistance, 2nd edn. World Health Organization https://www.who.int/publications/i/item/9789240082410 (2023).

Ismail, N. et al. Genetic variants and their association with phenotypic resistance to bedaquiline in Mycobacterium tuberculosis : a systematic review and individual isolate data analysis. Lancet Microbe 2 , e604–e616 (2021).

An, Q., Lin, R., Yang, Q., Wang, C. & Wang, D. Evaluation of genetic mutations associated with phenotypic resistance to fluoroquinolones, bedaquiline, and linezolid in clinical Mycobacterium tuberculosis : a systematic review and meta-analysis. J. Glob. Antimicrob. Resist. 34 , 214–226 (2023).

Gan, W. C., Ng, H. F. & Ngeow, Y. F. Mechanisms of linezolid resistance in mycobacteria. Pharmaceuticals 16 , 784 (2023).

CRyPTIC Consortium & The 100,000 Genomes Project. Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing. N. Engl. J. Med. 379 , 1403–1415 (2018).

Pankhurst, L. J. Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study. Lancet Respir. Med. 4 , 49–58 (2016).

Use of Targeted Next-generation Sequencing to Detect Drug-resistant Tuberculosis: Rapid Communication. World Health Organization https://www.who.int/publications/i/item/9789240076372 (2023).

The Use of Next-Generation Sequencing for the Surveillance of Drug-Resistant Tuberculosis: An Implementation Manual. World Health Organization https://www.who.int/publications/i/item/9789240078079 (2023).

Dippenaar, A. et al. Nanopore sequencing for Mycobacterium tuberculosis : a critical review of the literature, new developments, and future opportunities. J. Clin. Microbiol. 60 , e00646-21 (2022).

Sanchez-Padilla, E. et al. Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland. N. Engl. J. Med. 372 , 1181–1182 (2015).

Ng, K. C. et al. Xpert Ultra can unambiguously identify specific rifampin resistance-conferring mutations. J. Clin. Microbiol. 56 , 10–1128 (2018).

Daum, L. T. et al. Next-generation sequencing for characterizing drug resistance-conferring Mycobacterium tuberculosis genes from clinical isolates in the Ukraine. J. Clin. Microbiol. 56 , e00009-18 (2018).

Tagliani, E. et al. Culture and next-generation sequencing-based drug susceptibility testing unveil high levels of drug-resistant-TB in Djibouti: results from the first national survey. Sci. Rep. 7 , 17672 (2017).

Walker, T. M. et al. Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study. Lancet Infect. Dis. 13 , 137–146 (2013).

Mahomed, S., Mlisana, K., Cele, L. & Naidoo, K. Discordant line probe genotypic testing vs culture-based drug susceptibility phenotypic testing in TB endemic KwaZulu-Natal: impact on bedside clinical decision making. J. Clin. Tuberc. Mycobact. Dis. 20 , 100176 (2020).

Milimo, D. et al. Diagnosis of rifampicin-resistant tuberculosis: discordant results by diagnostic methods. Afr. J. Lab. Med. 7 , 1–4 (2018).

Votintseva, A. A. et al. Same-day diagnostic and surveillance data for ttuberculosis via whole-genome sequencing of direct respiratory samples. J. Clin. Microbiol. 55 , 1285–1298 (2017).

Brown, A. C. et al. Rapid whole-genome sequencing of Mycobacterium tuberculosis isolates directly from clinical samples. J. Clin. Microbiol. 53 , 2230–2237 (2015).

Doyle, R. M. et al. Direct whole-genome sequencing of sputum accurately identifies drug-resistant Mycobacterium tuberculosis faster than MGIT culture sequencing. J. Clin. Microbiol. 56 , e00666–18 (2018).

Goig, G. A. et al. Whole-genome sequencing of Mycobacterium tuberculosis directly from clinical samples for high-resolution genomic epidemiology and drug resistance surveillance: an observational study. Lancet Microbe 1 , e175–e183 (2020).

Van Rie, A. et al. Sequencing mycobacteria and algorithm-determined resistant tuberculosis treatment (SMARTT): a study protocol for a phase-IV pragmatic randomized controlled patient management strategy trial. Trials 23 , 864 (2022).

Sibandze, D. B. et al. Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing. Genome Med. 14 , 52 (2022).

Iyer, A. et al. Operationalising targeted next-generation sequencing for routine diagnosis of drug-resistant TB. Public Health Action. 13 , 43–49 (2023).

Cox, H. et al. Whole-genome sequencing has the potential to improve treatment for rifampicin-resistant tuberculosis in high-burden settings: a retrospective cohort study. J. Clin. Microbiol. 60 , e02362–21 (2022).

Kwong, J. C., McCallum, N., Sintchenko, V. & Howden, B. P. Whole genome sequencing in clinical and public health microbiology. Pathology 47 , 199–210 (2015).

Conradie, F. et al. Treatment of highly drug-resistant pulmonary tuberculosis. N. Engl. J. Med. 382 , 893–902 (2020).

Nyang’wa, B.-T. et al. A 24-week, all-oral regimen for rifampin-resistant tuberculosis. N. Engl. J. Med. 387 , 2331–2343 (2022).

Padmapriyadarsini, C. et al. Bedaquiline, delamanid, linezolid and clofazimine for treatment of pre-extensively drug-resistant tuberculosis. Clin. Infect. Dis. 76 , e938–e946 (2022).

Pym, A. S. et al. Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. Eur. Respir. J. 47 , 564–574 (2016).

Schnippel, K. et al. Effect of bedaquiline on mortality in South African patients with drug-resistant tuberculosis: a retrospective cohort study. Lancet Respir. Med. 6 , 699–706 (2018).

Ndjeka, N. et al. High treatment success rate for multidrug-resistant and extensively drug-resistant tuberculosis using a bedaquiline-containing treatment regimen. Eur. Respir. J. 52 , 1801528 (2018).

Ndjeka, N. et al. Treatment outcomes 24 months after initiating short bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens: a retrospective cohort study in South Africa. Lancet Infect. Dis. 22 , 1042–1051 (2022).

Zhao, Y. et al. Improved treatment outcomes with bedaquiline when substituted for second-line injectable agents in multidrug-resistant tuberculosis: a retrospective cohort study. Clin. Infect. Dis. 68 , 1522–1529 (2019).

Conradie, F. et al. Bedaquiline–pretomanid–linezolid regimens for drug-resistant tuberculosis. N. Engl. J. Med. 387 , 810–823 (2022).

Esmail, A. et al. An all-oral 6-month regimen for multidrug-resistant tuberculosis: a multicenter, randomized controlled clinical trial (the NExT study). Am. J. Respir. Crit. Care Med. 205 , 1214–1227 (2022).

Goodall, R. L. et al. Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial. Lancet 400 , 1858–1868 (2022).

WHO Operational Handbook on Tuberculosis. Module 4: Treatment of Drug-resistant Tuberculosis. World Health Organization https://www.who.int/publications/i/item/9789240006997 (2020).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02589782 (2021).

Clinical Trial Results Offer Hope to DR-TB patients with short, effective treatment. Médecins Sans Frontières https://www.msf.org/clinical-trial-finds-short-effective-safe-DR-TB-treatment (2022).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02333799 (2020).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT03086486 (2023).

Drug-resistant Tuberculosis Clinical Trials Progress Report. RESIST-TB https://www.resisttb.org/clinical-trials-progress-report (2023).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02619994 (2019).

Mok, J. et al. 9 months of delamanid, linezolid, levofloxacin, and pyrazinamide versus conventional therapy for treatment of fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-END): a multicentre, randomised, open-label phase 2/3 non-inferiority trial in South Korea. Lancet 400 , 1522–1530 (2022).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT04062201 (2022).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02754765 (2023).

Guglielmetti, L. et al. Evaluating newly approved drugs for multidrug-resistant tuberculosis (endTB): study protocol for an adaptive, multi-country randomized controlled trial. Trials 22 , 651 (2021).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT03896685 (2022).

ShORRT Initiative. Tropical Disease Research https://tdr.who.int/activities/shorrt-research-package (2022).

Tuberculosis Treatment: 2023 Pipeline Report. Treatment Action Group https://www.treatmentactiongroup.org/resources/pipeline-report/2023-pipeline-report/ (2023).

WHO Operational Handbook on Tuberculosis. Module 4: Treatment — Drug-resistant Tuberculosis Treatment, 2022 Update. World Health Organization https://www.who.int/publications/i/item/9789240065116 (2022).

Maugans, C. et al. Best practices for the care of pregnant people living with TB. Int. J. Tuberc. Lung Dis. 27 , 357–366 (2023).

Patankar, S. et al. Making the case for all-oral, shorter regimens for children with drug-resistant tuberculosis. Am. J. Respir. Crit. Care Med. 208 , 130–131 (2023).

Turkova, A. et al. Shorter treatment for nonsevere tuberculosis in African and Indian children. N. Engl. J. Med. 386 , 911–922 (2022).

Management of Multidrug-resistant Tuberculosis in Children: A Field Guide. Sentinel Project on Pediatric Drug-Resistant Tuberculosis https://sentinel-project.org/wp-content/uploads/2022/03/DRTB-Field-Guide-2021_v5.pdf (2022).

Furin, J., Tommasi, M. & Garcia-Prats, A. J. Drug-resistant tuberculosis: will grand promises fail children and adolescents? Lancet Child. Adolesc. Health 2 , 237–238 (2018).

Karo, B. et al. Isoniazid (INH) mono-resistance and tuberculosis (TB) treatment success: analysis of European surveillance data, 2002 to 2014. Eur. Surveill. 24 , 1800392 (2019).

Gegia, M., Winters, N., Benedetti, A., Soolingen, D. & Menzies, D. Treatment of isoniazid-resistant tuberculosis with first-line drugs: a systematic review and meta-analysis. Lancet Infect. Dis. 17 , 223–234 (2017).

Furin, J., Cox, H. & Pai, M. Tuberculosis. Lancet 393 , 1642–1656 (2019).

WHO Consolidated Guidelines on Tuberculosis: Module 1: Prevention: Tuberculosis Preventive Treatment. World Health Organization https://www.who.int/publications/i/item/9789240001503 (2020).

Guidelines for Programmatic Management of Tuberculosis Preventive Treatment in India. National TB Elimination Programme https://tbcindia.gov.in/WriteReadData/l892s/Guidelines%20for%20Programmatic%20Management%20of%20Tuberculosis%20Preventive%20Treatment%20in%20India.pdf (2021).

Latent Tuberculosis Infection: Updated and Consolidated Guidelines for Programmatic Management. World Health Organization https://www.who.int/publications/i/item/9789241550239 (2018).

Kherabi, Y., Tunesi, S., Kay, A. & Guglielmetti, L. Preventive therapy for contacts of drug-resistant tuberculosis. Pathogens 11 , 1189 (2022).

Huang, C. C. et al. Isoniazid preventive therapy in contacts of multidrug-resistant tuberculosis. Am. J. Respir. Crit. Care Med. 202 , 1159–1168 (2020).

Seddon, J. A. et al. Levofloxacin versus placebo for the prevention of tuberculosis disease in child contacts of multidrug-resistant tuberculosis: study protocol for a phase-III cluster randomised controlled trial (TB-CHAMP). Trials 19 , 693 (2018).

Fox, G. J. et al. Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial. BMJ Open 10 , e033945 (2020).

First Effective Treatment to Prevent Multidrug-Resistant TB. UCL News https://www.ucl.ac.uk/news/2023/nov/first-effective-treatment-prevent-multidrug-resistant-tb (2023).

US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT03568383 (2023).

WHO announces forthcoming updates on tuberculosis preventive treatment. World Health Organization https://www.who.int/news/item/13-02-2024-who-announces-forthcoming-updates-on-tuberculosis-preventive-treatment (2024).

Zimmerman, E., Smith, J., Banay, R., Kau, M. & Garfin, A. M. C. G. Behavioural barriers and perceived trade-offs to care-seeking for tuberculosis in the Philippines. Glob. Public Health 17 , 210–222 (2022).

Daftary, A., Frick, M., Venkatesan, N., & Pai, M. Fighting TB stigma: we need to apply lessons learnt from HIV activism. BMJ Glob. Health 2 , e000515 (2017).

Pradhan, A. et al. Internalized and perceived stigma and depression in pulmonary tuberculosis: do they explain the relationship between drug sensitivity status and adherence? Front. Psychiatry 13 , 869647 (2022).

Redwood, L. et al. Depression, stigma and quality of life in people with drug-susceptible TB and drug-resistant TB in Vietnam. Int. J. Tuberc. Lung Dis. 25 , 461–467 (2021).

Daftary, A., Padayatchi, N. & O’Donnell, M. Preferential adherence to antiretroviral therapy over tuberculosis treatment: a qualitative study of drug-resistant TB/HIV co-infected patients in South Africa. Glob. Public Health 9 , 1107–1116 (2014).

Susanto, T. D. et al. Anxiety and depression level of patients with multidrug-resistant tuberculosis (MDR-TB) in two hospitals in Banten province, Indonesia. Dialogues Health 2 , 100115 (2023).

Walker, I. et al. Depression and anxiety in patients with multidrug-resistant tuberculosis in Nepal: an observational study. Public Health Action 9 , 42–48 (2019).

Sommerland, N. et al. Evidence-based interventions to reduce tuberculosis stigma: a systematic review. Int. J. Tuberc. Lung Dis. 21 , S81–S86 (2017).

As’hab, P. P., Keliat, B. A. & Wardani, I. Y. The effects of acceptance and commitment therapy on psychosocial impact and adherence of multidrug-resistant tuberculosis patients. J. Public Health Res. 11 , 2737 (2022).

Thomas, B. E. et al. Psycho-socio-economic issues challenging multidrug resistant tuberculosis patients: a systematic review. PLoS ONE 11 , e0147397 (2016).

Udwadia, Z. & Furin, J. Quality of drug-resistant tuberculosis care: gaps and solutions. J. Clin. Tuberc. Mycobact. Dis. 16 , 100101 (2019).

Pai, M., Dewan, P. K. & Swaminathan, S. Transforming tuberculosis diagnosis. Nat. Microbiol. 8 , 756–759 (2023).

McKenna, L. et al. The 1/4/6x24 campaign to cure tuberculosis quickly. Nat. Med. 11 , 2337 (2023).

Zaunbrecher, M. A., Sikes, R. D. Jr, Metchock, B., Shinnick, T. M. & Posey, J. E. Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis . Proc. Natl Acad. Sci. USA 106 , 20004–20009 (2009).

Miotto, P. et al. A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis . Eur. Respir. J. 50 , 1701354 (2017).

Rifat, D. et al. Mutations in fbiD (Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis . Antimicrob. Agents Chemother. 65 , e01948–20 (2020).

Plinke, C. et al. embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation. J. Antimicrob. Chemother. 65 , 1359–1367 (2010).

Safi, H. et al. Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes. Nat. Genet. 45 , 1190–1197 (2013).

Srivastava, S., Ayyagari, A., Dhole, T. N., Nyati, K. K. & Dwivedi, S. K. emb nucleotide polymorphisms and the role of embB306 mutations in Mycobacterium tuberculosis resistance to ethambutol. Int. J. Med. Microbiol. 299 , 269–280 (2009).

Grant, S. S. et al. Baeyer-Villiger monooxygenases EthA and MymA are required for activation of replicating and non-replicating Mycobacterium tuberculosis inhibitors. Cell Chem. Biol. 23 , 666–677 (2016).

Dover, L. G. et al. EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrob. Agents Chemother. 51 , 1055–1063 (2007).

Vilchèze, C. et al. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis . Mol. Microbiol. 69 , 1316–1329 (2008).

Zhang, Y., Dhandayuthapani, S. & Deretic, V. Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc. Natl Acad. Sci. USA 93 , 13212–13216 (1996).

Ando, H., Miyoshi-Akiyama, T., Watanabe, S. & Kirikae, T. A silent mutation in mabA confers isoniazid resistance on Mycobacterium tuberculosis . Mol. Microbiol. 91 , 538–547 (2014).

Vilchèze, C. et al. Altered NADH/NAD + ratio mediates coresistance to isoniazid and ethionamide in mycobacteria. Antimicrob. Agents Chemother. 49 , 708–720 (2005).

Reeves, A. Z. et al. Aminoglycoside cross-resistance in Mycobacterium tuberculosis due to mutations in the 5′ untranslated region of whiB7 . Antimicrob. Agents Chemother. 57 , 1857–1865 (2013).

Liu, J. et al. Mutations in efflux pump Rv1258c (tap) cause resistance to pyrazinamide, isoniazid, and streptomycin in Mycobacterium tuberculosis . Front. Microbiol. 10 , 216 (2019).

Gopal, P. et al. Pyrazinamide triggers degradation of its target aspartate decarboxylase. Nat. Commun. 11 , 1661 (2020).

Scorpio, A. & Zhang, Y. Mutations in pncA , a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat. Med. 2 , 662–667 (1996).

Wong, S. Y. et al. Functional role of methylation of G518 of the 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis . Antimicrob. Agents Chemother. 57 , 6311–6318 (2013).

Catalogue of Mutations in Mycobacterium tuberculosis Complex and their Association with Drug Resistance. World Health Organization https://www.who.int/publications/i/item/9789240028173 (2021).

Farhat, M. R. et al. Rifampicin and rifabutin resistance in 1003 Mycobacterium tuberculosis clinical isolates. J. Antimicrob. Chemother. 74 , 1477–1483 (2019).

Nahid, P. et al. Treatment of drug-resistant tuberculosis. An Official ATS/CDC/ERS/IDSA clinical practice guideline. Am. J. Respir. Crit. Care Med. 200 , e93–e142 (2019).

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These authors contributed equally: Helen Cox, Marwan Ghanem.

Authors and Affiliations

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA

Maha Farhat & Marwan Ghanem

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA

Maha Farhat

Institute of Infectious Disease and Molecular Medicine, Wellcome Centre for Infectious Disease Research and Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa

Division of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany

Claudia M. Denkinger & Mirna S. Abd El Aziz

German Center for Infection Research (DZIF), partner site Heidelberg University Hospital, Heidelberg, Germany

Claudia M. Denkinger

P.D. Hinduja Hospital and Medical Research Centre, Mumbai, India

Camilla Rodrigues

Ulaanbaatar, Mongolia

Handaa Enkh-Amgalan

National TB Control Programme, Manzini, Eswatini

Debrah Vambe

School of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA

Cesar Ugarte-Gil

Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA

Jennifer Furin

McGill International TB Centre, McGill University, Montreal, Quebec, Canada

Madhukar Pai

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M.P., M.F., H.C., C.M.D., J.F. and M.G. wrote the article and, together with C.R. and M.S.A.E.A. researched data for the article. All authors contributed substantially to the discussion of the content and reviewed and/or edited the manuscript before submission.

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Refers to the delivery of anti-tuberculosis drug treatment under direct observation of health workers, community workers or family members with the goal of improving adherence.

(XDR-TB). Defined as multidrug-resistant or rifampicin-resistant tuberculosis with further resistance to fluoroquinolones and to either bedaquiline or linezolid or both (key second-line drugs).

(Hr-TB). Defined as resistance to isoniazid and susceptibility to rifampicin.

(MDR-TB). Defined as resistance to rifampicin and isoniazid, the two most important first-line drugs used to treat tuberculosis (TB), regardless of resistance to other TB drugs.

Defined as multidrug-resistant or rifampicin-resistant tuberculosis with resistance to fluoroquinolones.

(RMR-TB). Defined as resistance to rifampicin (Rif), with susceptibility to isoniazid.

(RR-TB). Defined as resistance to rifampicin (Rif), regardless of resistance to other tuberculosis (TB) drugs. Individuals with RR-TB are treated with regimens similar to those for multidrug-resistant TB (MDR-TB) and are therefore grouped with MDR-TB as MDR/RR-TB.

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Research Design: Qualitative, Quantitative, and Mixed Methods Approaches

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Research Design: Qualitative, Quantitative, and Mixed Methods Approaches Sixth Edition

The Sixth Edition has been fully revised to reflect the 7th edition of the P ublication Manual of the American Psychological Association with more inclusive language, updated citation styles, and updated writing suggestions. Learning objectives are now included at the start of each chapter. To help readers better achieve these learning objectives, the authors have clarified and improved the writing exercises to help readers better achieve these learning objectives. The final three chapters detailing qualitative, quantitative, and mixed methods now have a parallel structure so readers can better compare and contrast these approaches. Chapter 10 on mixed methods in particular has been restructured to reflect the latest developments in mixed methods and best practices. New research examples throughout help capture and demonstrate new trends in research.

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John W. Creswell, PhD, is a Professor of Family Medicine and Senior Research Scientist of

the Michigan Mixed Methods Program. He has authored numerous articles and 34 books on

mixed methods research, qualitative research, and research design. While at the University of

Nebraska–Lincoln, he held the Clifton Endowed Professor Chair, served as Director of the

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was an Adjunct Professor of Family Medicine at the University of Michigan and a consultant to

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a Senior Fulbright Scholar to South Africa in 2008 and to Thailand in 2012. In 2011, he co-led

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in the health sciences,” served as a Visiting Professor at Harvard’s School of Public Health and

received an honorary doctorate from the University of Pretoria, South Africa. In 2014, he was

the founding President of the Mixed Methods International Research Association. In 2015, he

joined the staff of Family Medicine at the University of Michigan to Co-Direct the Michigan

Mixed Methods Program. In 2017, he coauthored the American Psychological Association

“standards” on qualitative and mixed methods research. The fourth edition of this book on

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John W. Creswell is a Professor of Educational Psychology at Teachers College, University of Nebraska-Lincoln. He is affiliated with a graduate program in educational psychology that specializes in quantitative and qualitative methods in education. In this program, he specializes in qualitative and quantitative research designs and methods, multimethod research, and faculty and academic leadership issues in colleges and universities.

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Research Design: Second Edition: Quantitative, Qualitative, Mixed
With a new chapter on the literature review, this accessible step-by-step guide to using the five major approaches to research design is now in a thoroughly revised second edition. The prior edition's user-friendly features are augmented by a new companion website with worksheets keyed to each chapter. For each approach, the text presents a template for a research proposal and explains how to ...
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This bestselling text pioneered the comparison of qualitative, quantitative, and mixed methods research design. For all three approaches, John W. Creswell and new co-author J. David Creswell include a preliminary consideration of philosophical assumptions; key elements of the research process; a review of the literature; an assessment of the use of theory in research applications, and ...
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The eagerly anticipated Fourth Edition of the title that pioneered the comparison of qualitative, quantitative, and mixed methods research design is here! For all three approaches, Creswell includes a preliminary consideration of philosophical assumptions, a review of the literature, an assessment of the use of theory in research approaches, and refl ections about the importance of writing and ...
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This bestselling text pioneered the comparison of qualitative, quantitative, and mixed methods research design. For all three approaches, John W. Creswell and new co author J. David Creswell include a preliminary consideration of philosophical assumptions; key elements of the research process; a review of the literature; an assessment of the use of theory in research applications, and ...
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This best-selling text pioneered the comparison of qualitative, quantitative, and mixed methods research design. For all three approaches, John W. Creswell and new co-author J. David Creswell include a preliminary consideration of philosophical assumptions, key elements of the research process, a review of the literature, an assessment of the use of theory in research applications, and ...
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Research Design Qualitative, Quantitative, And Mixed Methods Approaches
The eagerly anticipated Fourth Edition of the title that pioneered the comparison of qualitative, quantitative, and mixed methods research design is here! For all three approaches, Creswell includes a preliminary consideration of philosophical assumptions, a review of the literature, an assessment of the use of
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Research Design: Qualitative, Quantitative, and Mixed Methods Approaches
This best-selling text pioneered the comparison of qualitative, quantitative, and mixed methods research design. For all three approaches, John W. Creswell and new co-author J. David Creswell include a preliminary consideration of philosophical assumptions, key elements of the research process, a review of the literature, an assessment of the ...
Research Design: Qualitative, Quantitative and Mixed Methods Approaches
The eagerly anticipated Fourth Edition of the title that pioneered the comparison of qualitative, quantitative, and mixed methods research design is here! For all three approaches, Creswell includes a preliminary consideration of philosophical assumptions, a review of the literature, an assessment of the use of theory in research approaches, and refl ections about the importance of writing and ...
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Research Design: Qualitative, Quantitative, and Mixed Methods Approaches
The sixth edition of the best-selling text, Research Design: Qualitative, Quantitative, and Mixed Methods Approaches by John W. Creswell and J. David Creswell, continues to provide clear and concise instruction for designing research projects or developing research proposals.This user-friendly text walks readers through research methods, from reviewing the literature to writing a research ...

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