diabetes 2 research article

Type 2 diabetes mellitus (T2DM) accounts for >90% of the cases of diabetes in adults. Resistance to insulin action is the major cause that leads to chronic hyperglycemia in diabetic patients. ... The authors are thankful to B. V. Patel Pharmaceutical Education and Research Development (PERD) Center, Ahmedabad, and AYUSH − Center of Excellence ...

However, type 2 diabetes makes up more than 90% of diagnosed diabetes cases in the United States. 35 Thus, our findings largely reflect risk-factor treatment and control in those with type 2 diabetes.

The downsides, however, are that 1) hypoglycemia is a constant threat, 2) proper insulin doses are not trivial to calculate, 3) compliance can vary especially in children and young adults, and 4) there can be side effects of a variety of types. Nonetheless, insulin therapy remains a mainstay treatment of diabetes.

1. Introduction. Diabetes Mellitus (DM) commonly referred to as diabetes, is a chronic disease that affects how the body turns food into energy .It is one of the top 10 causes of death worldwide causing 4 million deaths in 2017 , .According to a report by the International Diabetes Federation (IDF) , the total number of adults (20-79 years) with diabetes in 2045 will be 629 million from 425 ...

Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes worldwide. The number affected is increasing rapidly with alarming trends in children and young adults (up to age 40 years). Early detection and proactive management are crucial for prevention and mitigation of microvascular and macrovascular complications and mortality burden.

New estimates published this week in The Lancet indicate that more than 1·31 billion people could be living with diabetes by 2050 worldwide. That's 1·31 billion people living with a disease that causes life-altering morbidity, high rates of mortality, and interacts with and exacerbates many other diseases. The increase in prevalence (up from 529 million in 2021) is expected to be driven by ...

Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and ...

Type 2 diabetes articles from across Nature Portfolio. Type 2 diabetes mellitus, the most frequent subtype of diabetes, is a disease characterized by high levels of blood glucose (hyperglycaemia ...

The worldwide prevalence of type 2 diabetes mellitus (T2DM) in adults has increased from ~150 million affected people in 2000 to >450 million in 2019 and is projected to rise further to ~700 ...

For further reading, the following articles, referenced in this video as among the first studies to demonstrate that lifestyle changes could prevent or forestall type 2 diabetes, are available on ...

Journal of Diabetes Research is an open access journal that publishes articles related to type 1 and type 2 diabetes. Topics include etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications such as nephropathy. As part of Wiley's Forward Series, this journal offers a streamlined, faster publication ...

Recent Advances. ADA-funded researchers use the money from their awards to conduct critical diabetes research. In time, they publish their findings in order to inform fellow scientists of their results, which ensures that others will build upon their work. Ultimately, this cycle drives advances to prevent diabetes and to help people burdened by it.

Diabetes mellitus is associated with an increased risk of various cancers, especially gastrointestinal cancers and female-specific cancers. Hospitalization and mortality from various infections ...

Methods. In this trial involving participants with type 2 diabetes of less than 10 years' duration who were receiving metformin and had glycated hemoglobin levels of 6.8 to 8.5%, we compared the ...

The ADA is committed to continuing progress in the fight against type 2 diabetes by funding research, including support for potential new treatments, a better understating of genetic factors, addressing disparities, and more. For specific examples of projects currently funded by the ADA, see below. Greg J. Morton, PhD.

The chronic complications of type 2 diabetes are a major cause of mortality and disability worldwide [1, 2]. Clinical research is the main way to gain knowledge about long-term diabetic complications and reduce the burden of diabetes. This allows for designing effective programs for screening and follow-up and fine-targeted therapeutic ...

Type 2 diabetes mellitus (T2D) and hypertension, the 2 leading components of the global burden of disease, are commonly found to coexist. 1-3 The coexistence of T2D and hypertension confers a dramatically increased risk (2- to 4-fold) of cardiovascular disease, end-stage kidney disease, and death, compared with the normotensive and nondiabetic adults. 3 Hence, understanding the bidirectional ...

Diabetes mellitus (DM) is commonest endocrine disorder that affects more than 100 million people. worldwide (6% po pulation). It is caused b y deficiency or ineffective production of insulin by ...

feeling tired. losing weight unintentionally. Over time, diabetes can damage blood vessels in the heart, eyes, kidneys and nerves. People with diabetes have a higher risk of health problems including heart attack, stroke and kidney failure. Diabetes can cause permanent vision loss by damaging blood vessels in the eyes.

In this emulated comparative effectiveness target trial of glucagon-like peptide 1 (GLP-1) receptor agonist, sodium-glucose cotransporter 2 (SGLT2) inhibitor, dipeptidyl peptidase 4 (DPP-4) inhibitor, and sulfonylurea therapy among adults with type 2 diabetes at moderate cardiovascular disease risk, sulfonylurea use was associated with a significantly higher risk of hypoglycemia requiring ...

Restricting the eating window to eight hours a day significantly improves blood glucose control in adults at risk of type 2 diabetes irrespective of whether it is earlier or later in the day ...

For people managing heart failure without diabetes, the new finding that finerenone also reduced the risk of new-onset type 2 diabetes offers promise as well. "There is a clearly detrimental relationship between heart failure and diabetes that has a huge and harmful impact on symptoms and outcomes in patients," McMurray said.

MADRID — The nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone reduced the incidence of new-onset type 2 diabetes by approximately 25% in patients with heart failure with ...

Healthcare providers should adopt preventive measures for both asthma and type 2 diabetes in patients diagnosed with either condition, suggested a meta-analysis of 17 million individuals.

Type 1 diabetes mellitus affects 8.5 million people globally and is characterized by autoimmune destruction of pancreatic β cells. This Review discusses cell replacement therapies for T1DM and ...

A once-weekly injection of insulin is as effective as daily injections for blood sugar management in both type 1 and type 2 diabetes mellitus (T1DM/T2DM), studies have suggested. In a phase 3, non-inferior study, published in The Lancet on 10 September 2024, 692 adults with T1DM were randomly assigned to receive either once-weekly insulin efsitora […]

A better understanding of the current features of type 2 diabetes mellitus (T2DM)-related clinical trials is important for improving designs of clinical trials and identifying neglected areas of research. It was hypothesized that the trial registration policy promoted the designs of T2DM-related trials over the years. Therefore, this study ...

The menopause can increase your likelihood of developing heart disease, type 2 diabetes and hypertension — but exercise can help lower risk Published: September 12, 2024 6:40am EDT Rachel Churm ...

We published a report earlier this year that called for the government to commit to tackling the alarming rise in cases of type 2 diabetes among people aged under 40 years. There has been a 40% rise in type 2 diabetes diagnoses in younger people between 2016-17 and 2022-23. We need bold action from the government to reverse this rising trend.

FRIDAY, Sept. 13, 2024 (HealthDay News) -- Initially approved to treat type 2 diabetes, Ozempic and Mounjaro also can help people with type 1 diabetes lose weight and control their blood sugar ...